ADHFE1
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Official Full Name
alcohol dehydrogenase, iron containing, 1
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Overview
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of;4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 (PubMed 16616524)). -
Synonyms
ADHFE1; alcohol dehydrogenase, iron containing, 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial; FLJ32430; Fe containing alcohol dehydrogenase; ADH8; ADHFE 1; HOT; Hydroxyacid oxoacid transhydrogenase, mitochondrial; alcohol dehydrogenase 8; Fe-containing alcohol dehydrogenase 1; alcohol dehydrogenase iron-containing protein 1; HMFT2263;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ADHFE1-9422H | Recombinant Human ADHFE1, His-tagged | E.coli | His | 1-255a.a. | |
| Human | ADHFE1-355H | Recombinant Human ADHFE1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ADHFE1-32HCL | Recombinant Human ADHFE1 cell lysate | N/A |
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| Human | ADHFE1-944HF | Recombinant Full Length Human ADHFE1 Protein, GST-tagged | In Vitro Cell Free System | GST | 419 amino acids |
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| Mouse | ADHFE1-1358M | Recombinant Mouse ADHFE1 Protein | Mammalian Cell | His |
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| Mouse | ADHFE1-346M | Recombinant Mouse ADHFE1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ADHFE1-346M-B | Recombinant Mouse ADHFE1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ADHFE1-527R | Recombinant Rat ADHFE1 Protein | Mammalian Cell | His |
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| Rat | ADHFE1-183R-B | Recombinant Rat ADHFE1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ADHFE1-183R | Recombinant Rat ADHFE1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | ADHFE1-11815Z | Recombinant Zebrafish ADHFE1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADHFE1 Related Articles
ADHFE1 involved in several pathways and played different roles in them. We selected most pathways ADHFE1 participated on our site, such as Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, Metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADHFE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interconversion of 2-oxoglutarate and 2-hydroxyglutarate | D2HGDH;ADHFE1 |
| Metabolism | D2HGDH;IVD;CES1;SLC5A4;NOSTRIN;MED10;NUDT18;CYP2AD6;ETFA |
| Pyruvate metabolism and Citric Acid (TCA) cycle | PDK3B;MPC1;PDP1;PDK3;SLC16A1;PDK2B;BRP44;PDK4;D2HGDH |
| The citric acid (TCA) cycle and respiratory electron transport | PDK2;ADHFE1;COX16;MPC1;ATP5L;BRP44;PDK4;COX18;NDUFAF7 |
ADHFE1 has several biochemical functions, for example, hydroxyacid-oxoacid transhydrogenase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADHFE1 itself. We selected most functions ADHFE1 had, and list some proteins which have the same functions with ADHFE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydroxyacid-oxoacid transhydrogenase activity | |
| metal ion binding | PLAG1;UNK;KDM5D;NR1D1;ZNF728;FOLH1;BMI1A;ZBTB44;ZNF559 |
ADHFE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADHFE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADHFE1.
LIPC; GNAQ
- Q&As
- Reviews
Q&As (10)
Ask a questionADHFE1 has the potential to interact with other proteins or participate in protein complexes, indicating its involvement in complex cellular processes.
ADHFE1 exhibits a specific subcellular localization, and its dynamic changes in response to cellular signals or stimuli suggest a regulatory role in cellular processes.
ADHFE1 plays a role in cellular metabolism and contributes to specific biological processes, highlighting its functional significance in maintaining cellular homeostasis.
Genetic variations or polymorphisms in the ADHFE1 gene provide insights into individual differences and their impact on ADHFE1 expression or enzymatic function.
Post-translational modifications on ADHFE1 can affect its stability, enzymatic activity, or interaction with other molecules, revealing their regulatory role in its function.
ADHFE1 deficiency or overexpression can lead to cellular or physiological phenotypes, highlighting its essential role and the underlying mechanisms.
ADHFE1's activity can be modulated by known regulatory factors or cofactors, highlighting the complexity of its functional regulation.
ADHFE1 possesses enzymatic activity and catalyzes specific reactions, transforming specific substrates into products.
ADHFE1 represents a potential target for pharmacological modulation, offering possibilities for therapeutic interventions in relevant conditions or diseases.
ADHFE1 shows a tissue-specific expression pattern, and its developmental or spatial regulation suggests specific roles in different tissues or stages.
Customer Reviews (2)
Write a reviewHighly efficient in directing protein translocation to specific cellular compartments.
Displays excellent stability and compatibility with different detergents in membrane protein solubilization.
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