ADI1
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Official Full Name
acireductone dioxygenase 1
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Overview
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. -
Synonyms
ADI1; acireductone dioxygenase 1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; APL1; ARD; FLJ10913; HMFT1638; membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1; MTCBP 1; SIPL; 1; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Aci reductone dioxygenase; Acireductone dioxygenase (Ni(2+)-requiring); ADI 1; anti ADI1; EC 1.13.; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP-1; MTCBP1; MTND_HUMAN; Ni-ARD; Submergence induced protein 2 homolog; Submergence-induced protein 2 homolog; submergence induced protein 2; MT1-MMP cytoplasmic tail-binding protein-1; membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ADI1 Related Articles
ADI1 involved in several pathways and played different roles in them. We selected most pathways ADI1 participated on our site, such as Cysteine and methionine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cysteine and methionine metabolism | MAT2AA;DNMT3;CBS;DNMT1;BCAT1;MAT2AL;MTR;LDHAL6A;LDHC |
Metabolic pathways | PAH;SAT1;CERS1;B3GNT6;DLAT;GALT;NT5E;POLR2D;CYP2C18 |
ADI1 has several biochemical functions, for example, acireductone dioxygenase [iron(II)-requiring] activity, metal ion binding, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADI1 itself. We selected most functions ADI1 had, and list some proteins which have the same functions with ADI1. You can find most of the proteins on our site.
Function | Related Protein |
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acireductone dioxygenase [iron(II)-requiring] activity | |
metal ion binding | OAS1;PAK3;ZBTB8OS;ZFYVE28;CARS;ARHGEF28;NR2F1A;CYP2X9;EGR2 |
oxidoreductase activity | SNCA;RDH7;CYP2Y3;DHRS11A;LOXL2B;SDR42E1;MICAL2B;TESCA;CYB561A3A |
protein binding | TALDO1;ELK1;AZGP1;AGGF1;PIPOX;TBX6;SAV1;HTR6;HNF1B |
ADI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADI1.
MMP14; SRPK1; DBT; OSTF1
- Q&As
- Reviews
Q&As (12)
Ask a questionThere is limited evidence for the potential therapeutic targeting of ADI1 protein. However, some studies have suggested that modulating its activity could have potential therapeutic effects in certain diseases, such as cancer and neurodegenerative disorders. For example, ADI1 inhibitors have been shown to have cytotoxic effects on cancer cells, and ADI1-overexpressing cells have been found to be more resistant to oxidative stress-induced cell death. Further research is needed to determine the therapeutic potential of targeting ADI1 protein.
There are currently no drugs targeting ADI1 protein approved for clinical use. However, some compounds have been identified that can inhibit ADI1 activity, such as plant extracts and synthetic compounds. These compounds have shown some promise as potential anticancer agents in preclinical studies, but more research is needed to determine their efficacy and safety.
Yes, ADI1 has been shown to be involved in mitochondrial function. Specifically, it is localized to the inner mitochondrial membrane and has been found to modulate mitochondrial membrane potential and oxidative phosphorylation. It has also been shown to function as a regulator of mitochondrial morphology and dynamics. However, more research is needed to fully understand the role of ADI1 in mitochondrial function.
ADI1 protein is regulated at multiple levels, including post-transcriptional, post-translational, and protein-protein interaction mechanisms. For example, ADI1 expression can be regulated by microRNAs, and its activity can be modulated by phosphorylation and other post-translational modifications. Its interaction with other proteins, such as p53, also regulates its activity.
Yes, ADI1 protein is involved in various cellular processes, including energy metabolism, redox regulation, and cell signaling. Its primary function is as an enzyme that catalyzes the oxidation of several small molecules, including 2,4-dienoyl-CoA, quinines, and hydroxysteroids. It also has antioxidant activity and has been shown to regulate the activity of transcription factors and signaling pathways, such as p53 and the MAPK pathway.
Yes, ADI1 protein has been proposed as a potential target for cancer therapy. Its involvement in both tumor suppression and progression suggests that it may be a key regulator of cancer cell survival and proliferation. Small molecule inhibitors of ADI1 have been developed and tested in preclinical studies, with promising results in inhibiting tumor growth and invasion.
ADI1 protein is expressed in many tissues, but its expression levels can vary. For example, ADI1 is highly expressed in liver, kidney, and testes, but is expressed at lower levels in other tissues such as brain and heart. Its expression has also been detected in cancer cells and has been shown to be upregulated in certain cancers.
Yes, ADI1 protein has been implicated in various diseases and disorders. For example, mutations in the ADI1 gene have been associated with autosomal recessive cerebellar ataxia, a neurological disorder characterized by progressive loss of coordination and movement control. ADI1 has also been implicated in cancer, as discussed earlier.
ADI1 protein is expressed in a variety of tissues, including liver, kidney, lung, and brain. However, its expression levels can vary between tissues and cell types.
Yes, ADI1 protein is highly conserved across species, from bacteria to humans. This conservation suggests that it plays an important and evolutionarily conserved role in cellular processes.
There is limited evidence for the use of ADI1 protein as a biomarker for disease diagnosis or prognosis. However, some studies have suggested that its expression levels may be altered in certain diseases, such as prostate cancer and Alzheimer's disease. Further research is needed to determine its potential utility as a biomarker.
ADI1 protein interacts with p53 and modulates its transcriptional activity, resulting in the upregulation of pro-apoptotic genes and the downregulation of anti-apoptotic genes. This promotes the activation of the apoptotic pathway and can lead to cell death in response to cellular stress.
Customer Reviews (5)
Write a reviewthe purity of the protein has exceeded our expectations, with minimal interference caused by contaminants or impurities.
The protein is highly stable and able to maintain its activity even after being subjected to harsh conditions, which is crucial for carrying out rigorous biochemical assays.
the quality of ADI1 protein combined with the manufacturer's outstanding support has proved to be a valuable asset to the study.
the company's efficient and prompt delivery process has ensured that the protein arrived in excellent condition, allowing for immediate use in our experiments.
we are impressed with both the quality of the protein and the outstanding technical support provided by the manufacturer.
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