AES
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Official Full Name
amino-terminal enhancer of split
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Overview
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
AES; amino-terminal enhancer of split; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; gp130-associated protein GAM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AES Related Articles
AES involved in several pathways and played different roles in them. We selected most pathways AES participated on our site, such as Androgen receptor signaling pathway, Degradation of beta-catenin by the destruction complex, Presenilin action in Notch and Wnt signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | POU2F1B;KDM1A;NR2C2;SVILA;RNF4;DSTN;ZMIZ1;GNB2L1;SMARCE1 |
| Degradation of beta-catenin by the destruction complex | CTBP1;TLE1;TLE3;TLE3B;FAM123B;TLE2;CTBP2;TLE4;AES |
| Presenilin action in Notch and Wnt signaling | TLE1;KREMEN2;WIF1;AES |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | SALL4;TLE2;ZCCHC12;HBP1;TNIK;CYR61;IGF2BP1;CDX4;KCNIP4 |
| Repression of WNT target genes | AES;TLE2;TLE3;TLE3B;TLE4 |
| Signal Transduction | PROK1;RGS18;PROKR1;ARHGAP29;GPR37L1;ARHGAP11A;QRFP;IRBP;RHPN2 |
| Signaling by Wnt | SOX9B;KREMEN1;LGR5;WNT8-2;TNKS;PRICKLE1B;PRICKLE1;ASH2L;BCL9 |
AES has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AES itself. We selected most functions AES had, and list some proteins which have the same functions with AES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WASH1;PSIP1;IGHMBP2;RBM6;C19orf46;RPL10;DES;MST1R;RPL12 |
| transcription corepressor activity | CCAR1;GPS2;HDAC9;PBXIP1;HDAC4;TBL1X;SKOR1A;IRF2BP2;POU1F1 |
AES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AES here. Most of them are supplied by our site. Hope this information will be useful for your research of AES.
PTRH2; KRT13; FSD2; VPS37C; ARHGAP32; 386682
- Q&As
- Reviews
Q&As (10)
Ask a questionPost-translational modifications, such as phosphorylation or acetylation, and regulatory factors can modulate the activity or stability of AES protein, influencing its function in gene regulation and cellular processes.
Experimental techniques such as gene expression analysis, chromatin immunoprecipitation, or functional genomics approaches have been employed to investigate the functional significance of AES protein in gene regulation and cellular processes.
AES protein could be a potential pharmacological target to modulate gene expression, cellular processes, or serve as a therapeutic target for diseases associated with dysregulated gene expression or abnormal cell growth. Further research is needed to explore its therapeutic potential and develop targeted interventions.
Dysregulation or dysfunction of AES protein can disrupt cellular functions, developmental processes, and contribute to disease development, such as cancer, neurodegenerative disorders, or developmental disorders.
The cellular and subcellular localization patterns of AES protein can vary across different cell types and developmental stages. Experimental techniques such as immunofluorescence microscopy or subcellular fractionation can be used to determine its localization.
The expression of AES protein is regulated at the transcriptional level by specific promoters and transcription factors. Cellular signaling pathways and environmental cues can influence its expression in a context-dependent manner.
Genetic variations or mutations in the AES gene may impact the expression or function of AES protein, potentially leading to dysregulated gene expression, altered cellular processes, or disease susceptibility.
AES protein may interact with specific molecules, such as transcription factors or chromatin modifiers, forming protein complexes that modulate gene expression and cellular processes.
AES protein modulates gene expression and transcriptional activity by interacting with transcriptional regulators, co-repressors, or chromatin remodeling complexes, potentially leading to transcriptional repression or modulation of target genes.
AES protein plays a role in cellular processes such as cell proliferation, differentiation, or apoptosis, potentially through its interactions with transcription factors or modulation of gene expression. Experimental approaches including loss-of-function studies or functional assays can assess its function.
Customer Reviews (3)
Write a reviewUnderstanding protein-protein interaction networks in oxidative stress responses.
Detecting protein-protein interactions in ion transport and homeostasis.
Exploring protein-protein interactions involved in cytoskeleton organization.
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