AGRP
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Official Full Name
agouti related protein homolog (mouse)
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Overview
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. -
Synonyms
AGRP; agouti related protein homolog (mouse); agouti (mouse) related protein; agouti-related protein; Agrt; ART; ASIP2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Mammalian Cell
- Sf21 Insect Cell
- Fc
- GST
- hFc
- His
- His|SUMO
- HlgG1 Fc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGRP Related Articles
AGRP involved in several pathways and played different roles in them. We selected most pathways AGRP participated on our site, such as Adipocytokine signaling pathway, Syndecan-3-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adipocytokine signaling pathway | TRAF2;IKBKG;PCK1;AKT2L;ACSL3;PRKAG2A;NFKBIAB;RELA;PPARGC1A |
Syndecan-3-mediated signaling events | AGRP;COL20A1;PTN |
AGRP has several biochemical functions, for example, neuropeptide hormone activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGRP itself. We selected most functions AGRP had, and list some proteins which have the same functions with AGRP. You can find most of the proteins on our site.
Function | Related Protein |
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neuropeptide hormone activity | AVP;NPPA;PRLH;NPY;POMCA;TRH;HCRT;UCN;ADCYAP1 |
receptor binding | TENC1;LRRC4B;ANGPTL2;NUDT7;FGF20B;ACOT2;HMGCL;INSL4;PLA2G1B |
AGRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGRP here. Most of them are supplied by our site. Hope this information will be useful for your research of AGRP.
- Q&As
- Reviews
Q&As (10)
Ask a questionAGRP and the melanocortin system are potential targets for developing anti-obesity therapies, and research is ongoing to develop selective agonists or antagonists to modulate AGRP signaling.
AGRP is also implicated in the modulation of autonomic functions, such as blood pressure regulation and cardiovascular control.
AGRP inhibits the signaling of melanocortin receptors, leading to reduced cAMP production and affecting intracellular pathways involved in appetite and energy regulation.
AGRP acts as a key neuropeptide in the hypothalamus, integrating signals from peripheral tissues to regulate energy homeostasis, appetite, and body weight.
AGRP functions as an antagonist to melanocortin receptors, counteracting the effects of α-melanocyte-stimulating hormone (α-MSH), which promotes satiety and energy expenditure.
Yes, AGRP can interact with other neuropeptides, such as neuropeptide Y (NPY), and together they influence the central regulation of appetite and energy balance.
Dysregulation of AGRP expression or activity has been suggested to contribute to the development of certain eating disorders, such as binge eating disorder or hyperphagia.
While AGRP itself is not typically used as a diagnostic marker, studying its expression levels or genetic variations may provide insights into the risk and development of metabolic disorders.
AGRP acts on the melanocortin receptors in the brain, inhibiting their activation and resulting in an increase in appetite and a decrease in energy expenditure.
AGRP levels may have potential as a biomarker for monitoring the response to weight loss interventions, but further research is needed to establish its clinical utility.
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