AGAP1
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Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
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Overview
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1; centaurin, gamma 2 , CENTG2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; GGAP1; KIAA1099; AGAP 1; AGAP-1; AGAP1_HUMAN; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1; ArfGAP with GTPase domain ankyrin repeat and PH domain 1; Centaurin gamma 2; Centaurin-gamma-2; CENTG2; Cnt-g2; GGAP 1; GTP binding and GTPase activating protein 1; GTP-binding and GTPase-activating protein 1; MGC71657; centaurin, gamma 2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AGAP1-536H | Recombinant Human AGAP1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | AGAP1-0007H | Recombinant Human AGAP1 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | AGAP1-26447TH | Recombinant Human AGAP1, His-tagged | E.coli | His |
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| Human | AGAP1-8984HCL | Recombinant Human AGAP1 293 Cell Lysate | HEK293 | N/A |
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| Human | AGAP1-2579HF | Recombinant Full Length Human AGAP1 Protein, GST-tagged | In Vitro Cell Free System | GST | 392 amino acids |
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| Mouse | Agap1-1550M | Recombinant Mouse Agap1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rhesus Macaque | AGAP1-266R | Recombinant Rhesus monkey AGAP1 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | AGAP1-94R-B | Recombinant Rhesus Macaque AGAP1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | AGAP1-94R | Recombinant Rhesus Macaque AGAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AGAP1 Related Articles
AGAP1 involved in several pathways and played different roles in them. We selected most pathways AGAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | H2-Q10;SNX32;IL2RA;NEDD4;RNF41;STAMBP;RET;RAB22A;ARR3B |
AGAP1 has several biochemical functions, for example, GTP binding, GTPase activator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGAP1 itself. We selected most functions AGAP1 had, and list some proteins which have the same functions with AGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | SAR1A;ARL8BA;ATL2;RNF112;GNAL;RAC3;TUBA8L3;RAB20;ATL1 |
| GTPase activator activity | RGS9;TBC1D8B;RGS17;TBC1D9;JUN;RGS12;ARHGAP26;AGFG1;RGS16 |
| metal ion binding | ITGA5;ZBTB2B;ZNF264;ATMIN;ZNF396;ZFP42;NRP2A;CLEC4M;VAV2 |
| phospholipid binding | PTAFR;BPIFC;APOA2;APOB;SDPR;SPTB;NBEA;ABCG1;APOC3 |
AGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGAP1.
TK1; GRB7; SMN1
- Q&As
- Reviews
Q&As (20)
Ask a questionAGAP1 helps in the inactivation of Arf1 by accelerating its GTP hydrolysis, which is crucial for controlling vesicle trafficking between different cellular compartments.
Currently, there are no widely known drugs specifically targeting AGAP1, but research in this area could have therapeutic implications.
AGAP1 (Arf-GAP with GTPase, Ankyrin repeat, and PH domain 1) is a protein involved in regulating cellular processes like vesicle trafficking and membrane dynamics.
AGAP1 mutations have been associated with certain neurological conditions, potentially affecting neuronal development and function.
AGAP1 is one of several Arf-GAP proteins, each with distinct roles in cellular processes and vesicle trafficking pathways.
AGAP1 interacts with certain signaling molecules and receptors, influencing the transduction of signals within the cell.
The ankyrin repeat domain likely enables AGAP1 to interact with other proteins, contributing to its functional versatility.
AGAP1 has been linked to certain neurological disorders and cancers, but its precise roles in these contexts are still being investigated.
Yes, researchers often use techniques like gene knockdown or overexpression to study AGAP1's effects on cellular processes.
AGAP1 functions as a GTPase-activating protein (GAP) for the small GTPase Arf1, contributing to the regulation of membrane traffic and cellular signaling.
Yes, AGAP1's activity can be influenced by factors like cell stress, changes in membrane composition, and intracellular signaling.
AGAP1's functions are critical for maintaining proper cellular organization, membrane trafficking, and signal transduction, making it an important player in overall cell health.
AGAP1 helps regulate the formation and trafficking of vesicles between different cellular compartments, aiding in the proper distribution of cellular components.
AGAP1 interacts with Arf1, as well as other proteins involved in vesicle trafficking and membrane dynamics.
AGAP1 contains ankyrin repeat and PH (pleckstrin homology) domains, which are involved in protein-protein and protein-lipid interactions, respectively.
AGAP1 is found within cells, specifically in the cytoplasm and associated with membranes.
AGAP1 is expressed in various cell types, but its levels may vary depending on the tissue and cell context.
AGAP1 participates in processes like endocytosis, exocytosis, and maintenance of cellular membrane integrity.
AGAP1 stands for Arf-GAP with GTPase, Ankyrin repeat, and PH domain 1.
AGAP1's activity can be modulated by post-translational modifications, interactions with other proteins, and its localization within the cell.
Customer Reviews (5)
Write a reviewProtein's purity was evident in reproducible gel electrophoresis bands.
The product’s cost-effectiveness and clear instructions facilitated seamless incorporation into our work.
The insights gained from the protein product justified its cost, offering value for money.
It facilitated efficient DNA binding in all tested experimental conditions.
Despite its cost, the product’s contributions to our research goals rendered it an invaluable asset.
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