AGER
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Official Full Name
advanced glycosylation end product-specific receptor
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Overview
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] -
Synonyms
AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- hFc
- His
- Fc
- His(C
- ter)
- Flag
- GST
- His (Fc)
- Avi
- His|Flag|StrepII
- His|GST
- His|T7
- HlgG1 Fc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGER Related Articles
AGER involved in several pathways and played different roles in them. We selected most pathways AGER participated on our site, such as AGE/RAGE pathway, Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGER were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
AGE/RAGE pathway | ATF2;JUN;CHUK;MAPK14;DIAPH1;AGER;DDOST;TIRAP;EGFR |
Activated TLR4 signalling | TAB1;CREB1B;TICAM1;PELI3;CHUK;UBE2V1;SIGIRR;DUSP6;AGER |
Advanced glycosylation endproduct receptor signaling | LGALS3;S100B;APPA;SAA1;S100A12;ALCAMB;DDOST;AGER;APPB |
Cytosolic sensors of pathogen-associated DNA | AGER;CRCP;S100B;POLR3C;NLRP4E;APPA;RIPK3;LRRFIP1;SAA1 |
DEx/H-box helicases activate type I IFN and inflammatory cytokines production | APPA;CHST13;ALCAMB;AGER;SAA1;S100A12;S100B;APPB;DHX9 |
Immune System | SIGLEC14;SIGLEC7;CHST13;VPRBP;KIF3C;PELI2;TRIM69;ART1;AP1M2 |
Innate Immune System | CFD;SIGIRR;TXNIPA;CLEC5A;PELI3;TREM1;CLEC6A;UNC93B1;DUSP3 |
MyD88 cascade initiated on plasma membrane | PELI3;PELI1;TLR10;CHST13;DUSP3B;S100B;ALCAMB;DHX9;AGER |
AGER has several biochemical functions, for example, S100 protein binding, advanced glycation end-product receptor activity, high mobility group box 1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGER itself. We selected most functions AGER had, and list some proteins which have the same functions with AGER. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
S100 protein binding | ANXA2;KCNK3;FGF1A;S100A6;AHNAK;AGER;EZR;ANXA11;S100A11 |
advanced glycation end-product receptor activity | |
high mobility group box 1 binding | |
identical protein binding | ENTPD2;GAPDH;CLDN23;KDM6A;CREBZF;NEFL;TP53;VIM;COL18A1 |
protein binding | EIF3D;APBA3;TMEM203;CST5;CD4;CCDC130;PSMD5;INTS5;GIT1 |
receptor activity | KIR2DL3;GUCY1B3;IGF2R;RRBP1B;GFRA1B;MED17;P2RY2;Pla2r1;TNFRSF9 |
transmembrane signaling receptor activity | LILRB3;CR2;FZD1;SORL1;GPR133;GIPR;ICAM1;CD3G;CLEC2D |
AGER has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGER here. Most of them are supplied by our site. Hope this information will be useful for your research of AGER.
S100B; DIAPH1; TTR; GRB2; Diaph1; HMGB1; S100A1
- Q&As
- Reviews
Q&As (20)
Ask a questionAGER is involved in bone metabolism and might influence osteoporosis and bone diseases.
AGER levels might serve as biomarkers for certain diseases, including diabetes.
AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.
AGER contributes to skin aging through oxidative stress and collagen damage.
AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.
Yes, AGER activation contributes to inflammation and immune responses.
AGER activation can impair wound healing through inflammation and oxidative stress.
AGER contributes to neuroinflammation and might play a role in neurodegeneration.
AGER contributes to diabetic nephropathy and kidney dysfunction.
AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.
AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.
Researchers explore compounds that modulate AGER to mitigate its effects.
AGER contributes to diabetic complications by promoting inflammation and tissue damage.
AGER is studied for its implications in aging, diabetes, and various age-related diseases.
AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).
Consuming a low-AGE diet may help reduce AGER activation and its negative effects.
AGER activation affects immune cell functions and influences immune responses.
AGER activation is linked to cardiovascular diseases, including atherosclerosis.
Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.
Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.
Customer Reviews (5)
Write a reviewIt's quality was evident in consistent results across replicates.
Protein consistently upregulated the expression of tissue-specific markers.
Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.
It’s consistent outcomes supported reliable statistical analysis.
Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.
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