AGR2
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Official Full Name
anterior gradient 2 homolog (Xenopus laevis)
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Overview
AGR2 (Anterior Gradient 2), also known as AG2 (hAG2, HAG2 in human), or GOB4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development. -
Synonyms
AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gl;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AGR2 Related Articles
- AGR2 Related Research Area
AGR2 involved in several pathways and played different roles in them. We selected most pathways AGR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AGR2 has several biochemical functions, for example, dystroglycan binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGR2 itself. We selected most functions AGR2 had, and list some proteins which have the same functions with AGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dystroglycan binding | DAG1;VCL;AGRN;MAP2;AGR3;CLASP1;AGR2;GYLTL1B;DMD |
| epidermal growth factor receptor binding | SHC1;LINGO1B;Fert2;PLSCR1;AREG;BTC;TNK2;EREG;EGF |
| protein binding | LDHA;KATNA1;HRASLS5;IKZF3;MAPK3;ERCC5;DTX2;SIRPB1;KCNB1 |
| protein homodimerization activity | GOLGA5;STOM;PLDN;MFF;CADM4;AADAT;ACAT1;CADM2A;CITED1 |
AGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGR2.
POM121; FABP2; KRT31; CATSPER1; NUP62CL; UBQLN1; UBQLN1
- Q&As
- Reviews
Q&As (10)
Ask a questionHigh levels of AGR2 expression have been associated with poorer prognosis in several types of cancer, indicating its potential as a prognostic biomarker.
AGR2 promotes cancer cell migration and invasion by modulating signaling pathways involved in epithelial-to-mesenchymal transition (EMT) and extracellular matrix remodeling.
AGR2 has been implicated in protein folding, quality control, and secretion of other proteins. It is also involved in cancer progression and metastasis.
AGR2 is upregulated in response to ER stress and helps restore ER homeostasis by promoting protein folding and reducing ER stress-induced apoptosis.
AGR2 acts as a chaperone protein, facilitating the correct folding of secretory proteins and assisting in their quality control before secretion.
Several small molecules and antibodies targeting AGR2 have been developed as potential therapeutic agents, but further research is needed to validate their efficacy.
Some genetic variants in the AGR2 gene have been associated with an increased risk of certain cancers, including prostate and breast cancer.
AGR2 is overexpressed in various cancers, including breast, prostate, lung, and ovarian cancers, and has been associated with tumor growth, invasion, and drug resistance.
AGR2 can activate signaling pathways such as the PI3K/AKT pathway, Wnt/β-catenin pathway, and MAPK/ERK pathway, which are involved in cell survival, proliferation, and migration.
Yes, elevated levels of AGR2 have been detected in the blood and tissue samples of cancer patients, making it a potential biomarker for cancer diagnosis.
Customer Reviews (5)
Write a reviewVery impressed.
Excellent value for its price
The customer support was also excellent, providing prompt assistance when needed.
The customer service was responsive and assisted me with technical questions.
The purity and activity of the protein were exceptional, and it worked perfectly in my experiments.
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