AGRN

The measurement of AGRN levels or its isoforms in biological fluids or tissues may hold potential as diagnostic markers for certain neurological disorders, although further research is needed.

AGRN interacts with specific receptors on the muscle and nerve cells, initiating a signaling cascade that leads to the clustering of acetylcholine receptors and the formation and maintenance of the NMJ.

Yes, AGRN has been shown to have roles outside of the NMJ, including in the development of the central nervous system, kidneys, and cardiovascular system.

AGRN exists in multiple isoforms generated by alternative splicing. The most well-known isoforms include the neural isoforms (Agrin-N) and the muscle-specific isoforms (Agrin-M).

AGRN consists of several functional domains, including N-terminal laminin G-like (LG) domains, central EGF-like repeats, a C-terminal domain, and a heparin-binding site.

AGRN has been found to promote tumor cell migration, invasion, and metastasis by interacting with receptors and signaling pathways that regulate cell adhesion, migration, and angiogenesis.

AGRN expression is tightly regulated during development and can be influenced by various signaling pathways, including Wnt, BMP, and Notch signaling.

AGRN interacts with two major receptors: muscle-specific kinase (MuSK) on the postsynaptic membrane and low-density lipoprotein receptor-related protein 4 (LRP4) on the presynaptic membrane.

AGRN plays a role in regulating synaptic plasticity by modulating the structure and function of synapses, including their strength and stability.

AGRN regulates the maturation and stabilization of synapses by promoting the clustering of postsynaptic receptors and facilitating the development of pre- and postsynaptic specializations.