AGTRAP
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Official Full Name
angiotensin II receptor-associated protein
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Overview
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. -
Synonyms
AGTRAP; angiotensin II receptor-associated protein; type-1 angiotensin II receptor-associated protein; ATRAP; AT1 receptor-associated protein; ATI receptor-associated protein; angiotensin II, type I receptor-associated protein; MGC29646;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGTRAP Related Articles
AGTRAP involved in several pathways and played different roles in them. We selected most pathways AGTRAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AGTRAP has several biochemical functions, for example, angiotensin type II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTRAP itself. We selected most functions AGTRAP had, and list some proteins which have the same functions with AGTRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| angiotensin type II receptor activity | AGTR2;AGTRAP;CXCR3.2;AGTR1;RXFP3.2B;AGTR1B;APLNRB;AGTR1A;APLNRA |
| protein binding | LMF2;TDRKH;MARVELD3;IFRD2;GBP5;S100A2;BCL2L11;DRD4;CREB1 |
AGTRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTRAP.
PITPNC1; PDHX; PTPN9; ARFIP2; SPG21
- Q&As
- Reviews
Q&As (10)
Ask a questionYes, dysregulation of AGTRAP expression or function has been implicated in various cardiovascular conditions, including hypertension, cardiac hypertrophy, and heart failure.
Yes, AGTRAP can regulate AGTR1 expression by influencing its trafficking and degradation, thus impacting the overall abundance of AGTR1 receptors.
AGTRAP can modulate AGTR1 signaling by affecting the receptor's coupling to downstream signaling pathways, including G proteins and β-arrestins.
AGTRAP is widely expressed in various tissues, including the heart, kidney, liver, and brain.
AGTRAP acts as a negative regulator of AGTR1, thereby modulating the effects of angiotensin II on blood pressure control and vascular function.
AGTRAP is primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it interacts with AGTR1 during receptor maturation and trafficking.
AGTRAP physically associates with AGTR1 and modulates its activity by influencing receptor trafficking, signaling, and desensitization.
While the precise involvement of AGTRAP in specific diseases is still being elucidated, dysregulation of AGTRAP has been associated with cardiovascular diseases, hypertension, and altered response to angiotensin II.
AGTRAP has been reported to interact with several proteins involved in receptor trafficking, including G protein-coupled receptor-associated sorting proteins (GASP), which influence AGTR1 cell surface expression.
Techniques such as immunoprecipitation, co-immunoprecipitation, fluorescence microscopy, and genetic manipulation in cellular and animal models are employed to investigate AGTRAP's role and molecular mechanisms.
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