AHCY
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Official Full Name
adenosylhomocysteinase
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Overview
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AHCY; adenosylhomocysteinase; S adenosylhomocysteine hydrolase; SAHH; adoHcyase; S-adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
AHCY involved in several pathways and played different roles in them. We selected most pathways AHCY participated on our site, such as Biological oxidations, Cysteine and methionine metabolism, Folate Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHCY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | COMT;SULT1C4;CYP1B1;GGT6;CES1;CYP2K8;ADH8A;CYP3A7;PAOX |
| Cysteine and methionine metabolism | CBS;GCLM;GOT1;MAT2A;TST;DNMT3A;CTH;MPST;SDS |
| Folate Metabolism | ABCA1;SAA2;SAA2-SAA4;SAA1;SAA4;AHCY |
| Metabolic pathways | CYP2J2;RRM2;PHYKPL;NANP;SQLE;DHRS4L2;KHK;SHMT1;CYP51A1 |
| Metabolism | MED31;MED21;MMS19;APOC2;SLC25A15A;KCNB1;SCP2B;SLC25A1A;PDK3B |
| Metabolism of amino acids and derivatives | CDO1;NAGS;GLS2B;CKM;SLC25A2;IDO2;DCT;SLC25A15B;OAZ3 |
| Methylation | AHCY;TPMT.2;AS3MT |
| One Carbon Metabolism | AHCY;MTHFD2;ALDH1L1;MTFMT;FTCD;MTHFS;ST20-MTHFS |
AHCY has several biochemical functions, for example, NAD binding, adenosylhomocysteinase activity, adenyl nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHCY itself. We selected most functions AHCY had, and list some proteins which have the same functions with AHCY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | HADHA;LDHA;LDHB;CTBP2A;DLD;GPD1;AOX3;AOX1;GLYR1 |
| adenosylhomocysteinase activity | |
| adenyl nucleotide binding | |
| identical protein binding | ALDOA;HSD17B10;DYNLT1A;C1QL4;CLDN9;CBX3;INHBA;CRYAA;PARP1 |
| protein binding | GNPDA1;Cd24a;IL24;PYGO2;STK4;SLC3A1;URI1;ZNF124;PLRG1 |
AHCY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHCY here. Most of them are supplied by our site. Hope this information will be useful for your research of AHCY.
ANKRD40; APPBP2; C1orf50; ORF; Kif1c; EIF1B; BCAR3; MCC; HLA-B; YWHAZ; PAK2; PINX1; TRAF6
- Q&As
- Reviews
Q&As (10)
Ask a questionBy degrading SAH, AHCY ensures the availability of S-adenosylmethionine (SAM), a universal methyl donor essential for DNA, RNA, and protein methylation reactions.
Dysregulation of AHCY and altered methylation patterns have been linked to the development and progression of NAFLD and other liver pathologies.
AHCY employs a zinc-dependent mechanism to cleave the N-ribosidic bond of SAH, generating adenosine and homocysteine as products.
Targeting AHCY activity or SAM availability holds promise as a potential therapeutic strategy for conditions influenced by disrupted methylation.
Single nucleotide polymorphisms (SNPs) in the AHCY gene can affect enzyme activity and SAH levels, potentially influencing disease risk, including cardiovascular disorders and neurodegenerative diseases.
Homocysteine can be remethylated to methionine through the folate-dependent pathway or transsulfurated to cysteine via the transsulfuration pathway.
AHCY activity is intimately connected with folate-mediated one-carbon metabolism, affecting the availability of methyl groups for various methylation reactions.
AHCY expression can be modulated by transcriptional factors and epigenetic modifications, responding to changes in cellular methylation needs.
AHCY indirectly influences polyamine biosynthesis by providing the methyl groups required for polyamine synthesis.
AHCY possesses a TIM-barrel fold with an active site that houses the zinc ion critical for its hydrolytic activity.
Customer Reviews (5)
Write a reviewMy experiments have never been smoother since I started using this protein.
In our scientific pursuits, this lab protein has surpassed expectations, demonstrating exceptional quality and ease of use.
I highly recommend this protein to fellow researchers. It's a true gem!
We wholeheartedly endorse the lab protein product for its outstanding performance and its significant contribution to our research outcomes.
This protein is like a reliable teammate in the lab – always delivering excellent results.
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