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AHSP

  • Official Full Name

    alpha hemoglobin stabilizing protein

  • Overview

    Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
  • Synonyms

    AHSP; alpha hemoglobin stabilizing protein; EDRF; ERAF; alpha-hemoglobin-stabilizing protein; erythroid associated factor; erythroid-associated factor; alpha hemoglobin stabilising protein; erythroid differentiation-related factor; erythroid differentiation associated factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • GST
  • His
  • His|GST
  • His|S
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AHSP-614H Recombinant Human AHSP Protein, His-tagged E.coli His Met1~Ser102
Human AHSP-1392H Recombinant Human Alpha Hemoglobin Stabilizing Protein E.coli N/A
Human AHSP-26663TH Recombinant Human AHSP E.coli N/A
Human aHSP-3367H Recombinant Human aHSP, His-tagged, S tagged E.coli His/S 102
Human AHSP-8959HCL Recombinant Human AHSP 293 Cell Lysate HEK293 N/A
Human AHSP-0103H Recombinant Human AHSP Protein (Met1-Ser102), His-tagged E.coli His Met1-Ser102
Human AHSP-5962H Recombinant Human AHSP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AHSP-4866H Recombinant Human AHSP protein, GST-tagged E.coli GST 1-102aa
Mouse Ahsp-615M Recombinant Mouse Ahsp Protein, His-tagged E.coli His Ala2~Ser102
Rat Ahsp-616R Recombinant Rat Ahsp Protein, His/GST-tagged E.coli His/GST Ala2~Ser102
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AHSP Related Articles

AHSP involved in several pathways and played different roles in them. We selected most pathways AHSP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AHSP has several biochemical functions, for example, hemoglobin binding, protein binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHSP itself. We selected most functions AHSP had, and list some proteins which have the same functions with AHSP. You can find most of the proteins on our site.

Function Related Protein
hemoglobin bindingAHSP;CUBN;HBB;HP;HPR;LRP2
protein bindingKIF13B;NUP85;WSB1;NRP1;CLTA;AIRE;MET;MC5R;SH3YL1
unfolded protein bindingCALR3;CLPXA;DNAJA2;HSPA1A;HSP104;HSP90B1;APCS;HSP90AA1;DNAJB5

AHSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHSP here. Most of them are supplied by our site. Hope this information will be useful for your research of AHSP.

ZC3H12A; FKBP1A; UBE3A; HBA1; GRINL1A; TMEM165

Morrison, A; Wilson, K; et al. Characterization of a Monoclonal Antibody to Erythroid Related Factor. HYBRIDOMA 30:175-179(2011).
  • Q&As
  • Reviews

Q&As (10)

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What techniques are used to quantify the binding affinity between Ahsp and alpha-globin? 04/25/2022

echniques such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) are commonly employed to quantify the binding affinity and kinetics of Ahsp-alpha-globin interactions.

What is the connection between Ahsp and hemoglobinopathies? 01/20/2022

Ahsp deficiency can lead to unstable alpha-globin chains, contributing to the development of certain hemoglobinopathies like alpha-thalassemia.

How does Ahsp respond to cellular stress conditions? 11/17/2021

Ahsp expression may be upregulated during cellular stress to enhance its protective role in stabilizing alpha-globin chains and preventing protein aggregation.

What techniques are commonly used to study the interactions of Ahsp with alpha-globin chains? 03/09/2021

Techniques such as nuclear magnetic resonance (NMR), X-ray crystallography, and molecular dynamics simulations are commonly used to study protein-protein interactions involving Ahsp and alpha-globin.

How does Ahsp interact with chaperone proteins in the cell? 10/31/2020

Ahsp can interact with molecular chaperones like Hsp70 to assist in protein folding and prevent misfolding of alpha-globin chains.

How does Ahsp achieve its stabilizing function at the molecular level? 06/15/2020

Ahsp binds to free alpha-globin chains, preventing their aggregation and degradation by maintaining their folded state.

What is the significance of Ahsp in preventing thalassemia? 09/28/2019

Ahsp plays a role in preventing excess alpha-globin chains from aggregating and precipitating, which is a key factor in the pathogenesis of alpha-thalassemia.

How does Ahsp's function compare to other molecular chaperones in the cell? 07/12/2019

Ahsp's role is unique, focusing specifically on stabilizing alpha-globin chains, whereas other chaperones have broader functions in assisting protein folding and transport.

Can you explain the role of Ahsp in the context of iron metabolism? 12/04/2018

Ahsp indirectly influences iron metabolism by stabilizing alpha-globin chains and preventing their degradation, which in turn maintains balanced globin chain production and minimizes iron waste.

How does Ahsp contribute to maintaining red blood cell stability and lifespan? 09/03/2018

Ahsp's role in stabilizing alpha-globin chains helps prevent the formation of toxic aggregates that could damage red blood cells and shorten their lifespan.

Customer Reviews (5)

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Reviews
05/13/2022

    Outstanding product supplement. Worth every penny and arrived ahead of schedule.

    03/02/2021

      Top-notch lab protein for a fraction of the cost. Superb value for money.

      07/06/2020

        Great protein quality at an affordable price. Impressed with the results!

        12/27/2019

          Exceptional quality product that doesn't break the bank. Fast delivery too!

          09/18/2018

            This protein product is a game-changer – premium quality and budget-friendly.

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