AK1
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Official Full Name
adenylate kinase 1
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Overview
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. -
Synonyms
AK1; adenylate kinase 1; adenylate kinase isoenzyme 1; AK 1; myokinase; ATP-AMP transphosphorylase 1;
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- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- Chicken Muscle
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AK1 Related Articles
- AK1 Related Gene Family
AK1 involved in several pathways and played different roles in them. We selected most pathways AK1 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | PNP5A;NME2B.1;PNP;POLR3B;GUCY2E;POLR1A;POLA1;POLR1B;POLR3A |
Metabolic pathways | NME2;SRM;NT5C2A;IMPDH1;ALG3;UGT1A6;GNPDA1;CHKA;MAN2A2 |
AK1 has several biochemical functions, for example, ATP binding, adenylate kinase activity, nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK1 itself. We selected most functions AK1 had, and list some proteins which have the same functions with AK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MCM2;NME6;NOD1;MAPK8;AURKB;CAMK4;PTK2;MAST2;TTLL5 |
adenylate kinase activity | AK8;AK1;AK4;AK5;AK7;AK2 |
nucleoside diphosphate kinase activity | NME2;CMPK1;NME9;NME8;NME3;AK7;NME2A;NME6;AK9 |
AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK1.
KMT2C; TERF1; fldB; TINF2; TERF2IP; NBAS; MRE11A; TIA1; OGT; PCF11; CD2BP2; SLC12A2; DECR1; COBLL1; B3GALTL; RAB11FIP2; KDM3B; GEMIN5; CIRH1A
- Q&As
- Reviews
Q&As (25)
Ask a questionBesides its role in energy metabolism, AK1 protein has also been implicated in cell cycle regulation, DNA damage repair, regulation of protein-protein interactions, and modulation of cellular signaling pathways.
While adenylate kinase deficiency is the primary clinical consequence associated with AK1 protein mutations, altered AK1 expression or activity has been observed in some pathological conditions, including cancer, neurodegenerative disorders, and cardiovascular diseases.
AK1 protein is ubiquitously expressed across different tissues and organs in the body.
Yes, mutations in the AK1 gene can lead to a rare genetic disorder known as hemolytic anemia due to adenylate kinase deficiency. This condition is characterized by the destruction of red blood cells.
While specific therapeutic agents targeting AK1 protein are not currently available, there is ongoing research to explore its potential as a therapeutic target. Manipulating AK1 activity, expression, or regulation may hold promise for the treatment of certain diseases, particularly those where altered metabolism plays a role.
AK1 protein is predominantly found in the cytoplasm and the cytoskeleton of cells.
Yes, alternative splicing of the AK1 gene can give rise to different isoforms of AK1 protein. These isoforms might have variations in their enzymatic activity, subcellular localization, or interaction with other proteins. Further studies are needed to fully understand the functional significance of AK1 protein isoforms.
Some drugs may indirectly affect AK1 protein activity by altering cellular metabolism or energy levels. Drugs that target cellular respiration or ATP production, such as certain chemotherapeutic agents or metabolic modulators, may have an impact on AK1 protein activity, although it may not be their primary target.
Yes, AK1 protein has been reported to interact with a variety of other proteins involved in cellular processes, including cytoskeletal proteins, enzymes involved in ATP synthesis, and proteins involved in cell signaling pathways.
Future research on AK1 protein aims to elucidate its exact physiological roles in different tissues and organs. Additionally, understanding the underlying mechanisms of AK1-related disorders may lead to the development of targeted therapies.
There is evidence to suggest that AK1 protein may play a role in neurodegenerative disorders. Studies have shown altered AK1 expression and activity in the brains of individuals with Alzheimer's disease and Parkinson's disease. However, the exact mechanisms and implications are still being investigated.
Currently, there are no specific therapeutics targeting AK1 protein. However, further research on AK1 and its dysregulation may offer potential avenues for intervention in disorders related to adenylate metabolism.
Yes, animal models and cell lines are commonly used to study AK1 protein. Mouse models with AK1 gene knockout or overexpression have been generated to investigate its role in various physiological and pathological conditions. Additionally, cell lines derived from different tissues can be used to examine AK1 protein function and regulation in vitro.
Some small-molecule inhibitors of AK1 protein have been developed for research purposes, but they are not currently used in clinical settings. There is limited information on activators of AK1 protein.
AK1 protein is often studied through techniques such as protein purification, enzyme activity assays, gene knockout or overexpression experiments, immunofluorescence microscopy, and biochemical analyses to investigate its function, regulation, and potential therapeutic implications.
While AK1 protein is not commonly used as a diagnostic marker, its deficiency can be detected through genetic testing for the diagnosis of hemolytic anemia due to adenylate kinase deficiency.
While AK1 protein's role in immune system function is not well-characterized, some studies have suggested its involvement in T-cell activation and proliferation. However, further research is needed to clarify the specific mechanisms and implications in immune function.
While there is limited research on AK1 protein's role in fertility and reproductive health, some studies have suggested its involvement in sperm motility and function. Further investigations are needed to fully understand the potential impact of AK1 protein on reproductive processes.
Yes, AK1 protein can interact with various other proteins to form protein complexes or participate in cellular pathways. For example, it has been reported to physically interact with certain chaperones, signaling molecules, and other enzymes involved in nucleotide metabolism. These interactions can regulate AK1 protein activity and influence its cellular functions.
While there are currently no specific therapeutic agents targeting AK1 protein, some studies have explored its potential as a target in certain diseases, such as cancer. Manipulating AK1 activity or expression may have implications for the treatment of certain malignancies.
Currently, there is limited evidence to suggest using AK1 protein as a prognostic marker. However, further research is needed to explore its potential value as a prognostic indicator in specific diseases.
Yes, mutations in the AK1 gene have been linked to adenylate kinase deficiency, an autosomal recessive disorder characterized by hemolytic anemia and muscle weakness. It is a rare condition, and patients often present with symptoms such as fatigue, exercise intolerance, and elevated levels of certain molecules in the blood.
The activity of AK1 protein is regulated by various factors, including the concentrations of its substrates and products (AMP, ADP, and ATP), pH levels, and changes in cellular redox status.
AK1 protein plays a role in maintaining proper energy metabolism by regulating adenylate pools in the cell. It contributes to the production of ATP, the energy currency of the cell.
AK1 protein is expressed in a wide range of tissues, but its expression levels can vary. It is highly expressed in tissues with high energy demands, such as skeletal muscle, heart, and brain. However, it is also found in other tissues, albeit at lower levels. This widespread expression reflects the importance of AK1 protein in nucleotide metabolism and energy homeostasis throughout the body.
Customer Reviews (4)
Write a reviewAK1 protein boasts an exemplary caliber, rendering it a remarkable choice that impeccably aligns with my experimental prerequisites.
the manufacturer's commitment to excellence extends beyond the mere production of the AK1 protein.
Their exceptional technical support team stands ready to tackle any obstacles or queries I may encounter during my experimental journey.
Its exceptional quality and consistency instill confidence in attaining accurate and reproducible results
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