AKAP2
-
Official Full Name
A kinase (PRKA) anchor protein 2
-
Overview
The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AKAP2; A kinase (PRKA) anchor protein 2; PRKA2; A-kinase anchor protein 2; AKAP KL; DKFZp564L0716; KIAA0920; protein kinase A2; A kinase anchor protein 2; AKAP 2; AKAPKL; PALM 2; PALM2; PRKA 2; Protein kinase A anchoring protein 2; AKAP-2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AKAP2-107H | Recombinant Human AKAP2 Protein, His-tagged | E.coli | N-His | Met1-Pro235 | |
Mouse | AKAP2-1476M | Recombinant Mouse AKAP2 Protein | Mammalian Cell | His | ||
Mouse | Akap2-3025M | Recombinant Mouse Akap2, His-tagged | E.Coli or Yeast | His | 880 | |
Mouse | AKAP2-428M | Recombinant Mouse AKAP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | AKAP2-428M-B | Recombinant Mouse AKAP2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | AKAP2-590R | Recombinant Rat AKAP2 Protein | Mammalian Cell | His | ||
Rat | AKAP2-246R-B | Recombinant Rat AKAP2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | AKAP2-246R | Recombinant Rat AKAP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | AKAP2-8010Z | Recombinant Zebrafish AKAP2 | Mammalian Cell | His | ||
Chicken | AKAP2-4498C | Recombinant Chicken AKAP2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AKAP2 involved in several pathways and played different roles in them. We selected most pathways AKAP2 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
G Protein Signaling Pathways | AKAP5;AKAP13;AKAP1B;AKAP12B;Akap2;GNB5B;AKAP6;AKAP12;GNA13 |
AKAP2 has several biochemical functions, for example, protein domain specific binding, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP2 itself. We selected most functions AKAP2 had, and list some proteins which have the same functions with AKAP2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
protein domain specific binding | WNT3A;NF2;MTOR;ARFIP1;ICA1L;SP100;STMN3;TBL1X;STXBP1 |
protein kinase A binding | DACT3;NBEA;MYRIP;AKAP5;Akap3;AKAP12;RPS3;AKAP13;DACT1 |
AKAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP2.
- Q&As
- Reviews
Q&As (21)
Ask a questionAKAP2 is involved in various cellular processes, including regulation of PKA-mediated phosphorylation events, modulation of cAMP-dependent signaling pathways, and localization of PKA to specific subcellular compartments.
Yes, AKAP2 contains several functional domains. The N-terminal domain contains a PKA-binding site, allowing its interaction with PKA regulatory subunits. The central leucine-rich repeat region is involved in protein-protein interactions, potentially mediating interactions with other proteins. The C-terminal domain also contributes to protein-protein interactions and may have additional functional roles.
There have been limited studies involving AKAP2 knockout or knockdown. However, preliminary research using animal models and cell-based studies suggest that AKAP2 plays important roles in neuronal development, cardiac function, and cell signaling. Future research involving AKAP2 manipulation could provide further insights into its functions and potential therapeutic applications.
AKAP2 is widely expressed in various tissues and organs, although its expression levels may vary among different cell types. It is expressed in the brain, heart, skeletal muscle, liver, kidney, lung, and other tissues. Its expression pattern suggests that AKAP2 is involved in multiple physiological processes throughout the body.
AKAP2 is involved in the regulation of a variety of physiological processes. It plays a crucial role in mediating PKA-dependent signaling pathways by anchoring PKA to specific subcellular compartments. This allows for precise spatial and temporal regulation of PKA activity and subsequent phosphorylation of target proteins. AKAP2 has been implicated in the regulation of cardiac function, neuronal development, synaptic plasticity, neurotransmitter release, and dendritic spine maintenance.
Currently, there are no known diseases directly associated with mutations in AKAP2. However, dysregulation of AKAP2 expression or function may contribute to various cellular dysfunctions and diseases.
Given its involvement in cellular processes and signaling pathways, AKAP2 could potentially be targeted for therapeutic interventions. However, further research is required to fully understand its exact role and potential therapeutic implications.
AKAP2 is primarily known for its role in modulating PKA-mediated signaling pathways. It facilitates the spatial and temporal regulation of PKA activity by anchoring PKA to specific subcellular compartments. As a result, AKAP2 can influence various downstream signaling pathways that are regulated by PKA, including cAMP-dependent pathways.
At present, there have been no disease-associated mutations reported in the AKAP2 gene. However, considering its involvement in various cellular processes and the emerging role of AKAPs in disease pathogenesis, it is possible that future studies may uncover disease-associated mutations or genetic variants in the AKAP2 gene.
Currently, there are no known specific inhibitors or activators targeting AKAP2. However, the development of small-molecule inhibitors or activators that selectively modulate AKAP2's interactions or functions could hold potential for future therapeutic interventions. Further research is needed in this area.
Currently, there is limited research on using AKAP2 as a biomarker. However, as AKAP2 has been implicated in various cellular processes and dysregulation of its expression or function may contribute to disease progression, it is worth exploring its potential as a biomarker in specific diseases or conditions.
Yes, AKAP2 has been implicated in neuronal development and synaptic signaling. It may play a role in the regulation of neuronal plasticity, neurotransmitter release, and dendritic spine maintenance. However, more research is required to fully understand the precise mechanisms and functional significance of AKAP2 in the nervous system.
Yes, AKAP2 protein is highly conserved across species, indicating its importance in cellular processes.
Yes, AKAP2 interacts with several proteins, including PKA regulatory subunits, phosphodiesterase 4D (PDE4D), and A-kinase anchor protein 1 (AKAP1). These interactions enable the formation of protein complexes involved in signaling pathways.
Although there are no specific therapeutic interventions targeting AKAP2 currently available, its role in signaling pathways and its potential involvement in disease progression make it an interesting target for future research. Modulation of AKAP2's interactions or functions could hold therapeutic potential for certain diseases, including neurological disorders, cardiac disorders, and cancer. Further studies are needed to fully explore the therapeutic opportunities related to AKAP2.
There is limited information on the direct interaction between AKAP2 and other AKAPs. However, there is evidence to suggest that AKAP2 can form complexes with other AKAPs and participate in multiprotein signaling complexes. These interactions may help coordinate the spatial organization of signaling molecules and promote efficient signal transduction within cells.
Although AKAP2 is primarily localized in the cytoplasm, there is evidence of its presence in the mitochondria. However, the specific binding partners of AKAP2 in the mitochondria are not well-characterized. Further research is needed to identify and understand the functional significance of AKAP2's interactions in this organelle.
There is currently limited research on the role of AKAP2 in cancer. However, some studies have suggested that dysregulation of AKAP2 expression could contribute to cancer progression or prognosis in certain types of cancer. Further investigation is needed to fully understand its involvement in cancer biology.
Yes, AKAP2 expression can be regulated at the transcriptional level. It has been shown that various signaling pathways and transcription factors can modulate AKAP2 expression. However, the exact mechanisms and regulatory elements involved in AKAP2 gene expression are still not fully understood.
Several studies have investigated the role of AKAP2 in intracellular signaling, neuronal development, and cardiac function. These studies have shed light on its structural organization, interacting partners, and functional significance in various biological processes.
There is limited information available on post-translational modifications of AKAP2. However, phosphorylation of AKAP2 by PKA has been reported, suggesting that it may undergo post-translational modifications to regulate its activity or interactions with other proteins.
Customer Reviews (4)
Write a reviewTheir commitment to customer satisfaction inspires confidence, knowing that I have the necessary support to overcome any hurdles along the way.
the manufacturer excels in providing outstanding technical support, offering invaluable assistance in troubleshooting any challenges that may arise.
the AKAP2 protein's unwavering quality, coupled with exceptional technical support from the manufacturer, makes it the optimal choice for my research needs.
The manufacturer's knowledgeable and responsive team of experts is readily available to address any concerns or queries, ensuring a seamless experimental process.
Ask a Question for All AKAP2 Products
Required fields are marked with *
My Review for All AKAP2 Products
Required fields are marked with *