AKAP3
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Official Full Name
A kinase (PRKA) anchor protein 3
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Overview
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. -
Synonyms
AKAP3; A kinase (PRKA) anchor protein 3; A-kinase anchor protein 3; AKAP110; cancer/testis antigen 82; CT82; Fibrous Sheath Protein of 95 kDa; FSP95; SOB1; AKAP-3; AKAP 110; fibrousheathin 1; fibrousheathin I; fibrousheathin-1; fibrous sheath protein, 95k;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AKAP3-108H | Recombinant Human AKAP3 Protein, His-tagged | E.coli | N-His | Met1-Ser176 | |
Mouse | AKAP3-1477M | Recombinant Mouse AKAP3 Protein | Mammalian Cell | His | ||
Mouse | Akap3-3026M | Recombinant Mouse Akap3, His-tagged | E.Coli or Yeast | His | 864 | |
Mouse | AKAP3-429M-B | Recombinant Mouse AKAP3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | AKAP3-429M | Recombinant Mouse AKAP3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bovine | AKAP3-3027B | Recombinant Bovine AKAP3, His-tagged | E.Coli or Yeast | His | 858 |
- Involved Pathway
- Protein Function
- Interacting Protein
- AKAP3 Related Articles
AKAP3 involved in several pathways and played different roles in them. We selected most pathways AKAP3 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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G Protein Signaling Pathways | AKAP8;GNG13B;AKAP1B;GNGT2A;GNA13;Akap2;AKAP13;Akap3;AKAP12 |
AKAP3 has several biochemical functions, for example, protein binding, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP3 itself. We selected most functions AKAP3 had, and list some proteins which have the same functions with AKAP3. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | GLB1;HSPA9;TXLNB;KRT8;FEN1;DNAIC2;WWOX;TXNDC11;CD300LD |
protein kinase A binding | AKAP5;AKAP4;AKAP12;DACT2;AKAP12B;Akap2;DACT1;AKAP17A;AKAP14 |
AKAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP3.
- Q&As
- Reviews
Q&As (23)
Ask a questionTo date, no disease-causing mutations or genetic variants in the AKAP3 gene have been identified. However, given its importance in sperm motility and fertility, it is possible that genetic abnormalities in AKAP3 could contribute to male infertility or other reproductive disorders. Further research is needed to explore potential disease associations.
At present, there is limited evidence suggesting that AKAP3 could serve as a biomarker for male fertility or reproductive disorders. However, ongoing research is exploring the potential use of protein biomarkers in evaluating sperm quality and male fertility. As our understanding of AKAP3's role in sperm function and male fertility improves, it is possible that it could be considered as a biomarker in the future, along with other molecular markers, to assess male fertility status and reproductive disorders.
While AKAP3 is involved in sperm motility and male fertility, it is not currently used as a biomarker for male infertility or reproductive disorders. However, given its importance in these processes, continued research may uncover the potential for AKAP3 to serve as a biomarker for certain conditions. Currently, diagnostic methods for male infertility primarily focus on assessing sperm parameters such as count, motility, and morphology.
Yes, changes in AKAP3 expression or activity can impact male fertility. AKAP3 is crucial for the assembly and organization of the fibrous sheath in sperm cells, which is necessary for sperm movement. Any disruptions in AKAP3 function could lead to abnormalities in the fibrous sheath, resulting in impaired sperm motility and reduced fertility. Studies have suggested that alterations in AKAP3 expression or mutations in the AKAP3 gene could be associated with male infertility.
Currently, there are no specific drugs or interventions targeting AKAP3 for therapeutic purposes. However, given its importance in sperm motility and male fertility, further research to identify potential therapeutic targets within the AKAP3 signaling pathway is underway. Modulating AKAP3 activity or its interacting partners might hold potential in the development of future treatments for male infertility or reproductive disorders. However, it is important to note that more research is needed in this area before any specific interventions can be developed.
Although AKAP3 plays a crucial role in sperm motility and fertility, there is currently limited research on directly targeting AKAP3 for contraceptive purposes. However, the potential for AKAP3 modulation to affect sperm function suggests that further exploration in this area may be warranted. Any potential development of AKAP3-based contraceptives would require extensive research and development to ensure safety, efficacy, and reversibility.
Currently, there are no known specific inhibitors of AKAP3 activity or downstream signaling pathways. However, research is continuously being conducted to identify compounds or therapeutic targets that may modulate the function or activity of AKAP3. By understanding the specific interactions and mechanisms involved in the AKAP3 signaling pathway, it may be possible to identify potential inhibitors in the future for therapeutic purposes.
Targeting AKAP3 for male contraceptive development could have significant implications for reproductive health. Since AKAP3 is involved in sperm motility, any disruption or inhibition of its function could potentially lead to decreased or impaired sperm movement, potentially leading to temporary or reversible infertility. However, it is important to note that the development of male contraceptives targeting AKAP3 would require careful consideration of potential side effects and long-term implications.
Yes, changes in AKAP3 expression or activity can potentially affect the fertilization process. AKAP3 is involved in sperm motility, which is crucial for sperm cells to reach and penetrate the oocyte (egg) during fertilization. If there are abnormalities in the fibrous sheath assembly or organization due to altered AKAP3 function, it could impair sperm movement and hinder successful fertilization. However, more research is needed to fully understand the precise role of AKAP3 in the fertilization process and how changes in its expression or activity could impact fertility.
While AKAP3 is primarily known for its role in sperm motility, there is evidence to suggest its involvement in other cellular processes as well. It has been shown to interact with other signaling molecules, such as adenylate cyclase and phosphodiesterase, indicating its potential role in modulating cyclic AMP (cAMP) signaling pathways. Altered cAMP signaling has been implicated in various cellular processes, including cell growth, differentiation, and survival. However, more research is needed to fully understand the broader functions of AKAP3 beyond sperm motility.
Yes, several animal models and studies have been conducted to investigate AKAP3 function in fertility. Animal models such as mice, rats, and rabbits have been used to study the role of AKAP3 in sperm development, motility, and fertility. These studies provide valuable insights into the molecular mechanisms and physiological functions of AKAP3 in reproductive processes, which can help inform further research on human fertility and potential therapeutic interventions.
Currently, there is limited research on whether AKAP3 mutations or dysregulation can lead to other health conditions or diseases beyond male infertility. However, studies have suggested a potential link between AKAP3 polymorphisms and an increased risk of testicular cancer. Further research is necessary to understand the potential implications of AKAP3 mutations or dysregulation on other health conditions or diseases.
There have been reports of genetic mutations and polymorphisms in the AKAP3 gene associated with male fertility problems. A study identified a genetic mutation in the AKAP3 gene in a family with multiple cases of infertility. Another study found a genetic polymorphism in the AKAP3 gene that was associated with reduced sperm motility and increased risk of male infertility. These findings suggest that genetic variations in the AKAP3 gene could contribute to male fertility issues, but further research is necessary to confirm and fully understand their impact.
AKAP3 is primarily expressed in the testes, specifically in developing sperm cells. It plays a crucial role in spermatogenesis and sperm motility. While AKAP3 expression is predominantly found in sperm cells, there is some evidence suggesting that it may be expressed in low levels in other tissues as well, such as the heart, lungs, and brain. However, its functional significance in these tissues is not well understood, and more research is needed to fully characterize AKAP3 expression beyond the testes.
AKAP3 is predominantly expressed in the testes, specifically in the sperm cells. Its expression is limited to the male reproductive system and is primarily associated with spermatogenesis and sperm function. Its expression in other tissues or organs is negligible or absent.
AKAP3 interacts with various proteins involved in sperm motility to regulate and coordinate their functions. It interacts with structural proteins like AKAP4 and AKAP82 in the fibrous sheath of the sperm tail, which plays a crucial role in generating the whip-like movement. AKAP3 also interacts with enzymes like protein kinase A (PKA) and protein kinase C (PKC), which are involved in signal transduction pathways regulating sperm motility. These interactions help facilitate the proper assembly and organization of the sperm tail and the regulation of intracellular signaling pathways involved in motility.
While AKAP3's primary function is associated with sperm motility, it is also involved in other cellular processes. For example, AKAP3 has been found to interact with other proteins involved in DNA repair, suggesting a potential role in maintaining genomic stability. Additionally, AKAP3 has been implicated in the regulation of protein localization within cells, specifically in the context of the fibrous sheath structure in sperm tails. Further research is needed to fully elucidate the extent of AKAP3's involvement in other cellular processes.
As of now, there are no clinical trials specifically testing AKAP3-related therapies for male infertility. However, ongoing research in the field of male contraception and reproductive health may lead to future clinical trials evaluating the efficacy and safety of potential AKAP3-targeted therapies. Clinical trials often take time to conduct and require a rigorous evaluation process to ensure patient safety and therapeutic efficacy.
AKAP3 can interact with other AKAPs and signaling molecules to form multiprotein complexes involved in sperm function. It has been shown to interact with PKA, as well as other fibrous sheath-associated proteins, such as AKAP4 and AKAP82. These interactions are crucial for the proper assembly and organization of the fibrous sheath and the regulation of sperm motility.
There is limited research on factors or environmental influences that can directly regulate AKAP3 expression or activity. However, studies have suggested that hormonal factors, such as FSH and testosterone, can influence AKAP3 expression. Additionally, environmental factors, such as exposure to toxins or chemicals, may indirectly affect AKAP3 expression by disrupting the overall testicular environment or impairing spermatogenesis. Further research is needed to identify specific factors and provide a comprehensive understanding of the regulation of AKAP3 expression and activity.
Currently, there are no specific therapeutic interventions targeting AKAP3. However, understanding its role in sperm motility and fertility could have implications for the development of potential treatments for male infertility or reproductive disorders. Further research is needed to explore the therapeutic potential of targeting AKAP3 or related signaling pathways.
The regulation of AKAP3 expression is not fully understood, but studies have identified some potential regulatory mechanisms. It has been reported that AKAP3 expression is under the control of testicular-specific transcription factors, such as CREB (cAMP response element-binding) and SOX9 (SRY-related HMG box 9). Additionally, hormonal factors, such as follicle-stimulating hormone (FSH) and testosterone, have been shown to influence AKAP3 expression. Further research is needed to elucidate the complete regulatory network governing AKAP3 expression.
Currently, there are no specific genetic tests available to identify AKAP3 mutations or dysregulation. Due to limited research and understanding of AKAP3's role in male infertility, diagnostic genetic testing is not routinely performed for AKAP3 gene variants. However, as research advances, it is possible that specialized genetic tests may become available in the future to identify specific AKAP3 mutations or dysregulation.
Customer Reviews (4)
Write a reviewThe AKAP3 protein exudes excellence, boasting exceptional quality that surpasses my experimental requirements.
the manufacturer of the AKAP3 protein offers unparalleled technical support that can effectively address any challenges I may encounter.
Utilizing the AKAP3 protein in my experiments instills a sense of assurance, as it promises to be a powerful tool in advancing my scientific investigations.
With its outstanding purity and functionality, this protein is poised to seamlessly align with the objectives of my research, delivering accurate and reliable results.
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