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ALAD

  • Official Full Name

    aminolevulinate dehydratase

  • Overview

    The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.
  • Synonyms

    ALAD; aminolevulinate dehydratase; aminolevulinate, delta , dehydratase; delta-aminolevulinic acid dehydratase; ALADH; PBGS; porphobilinogen synthase; MGC5057; OTTMUSP00000009377; RP11-10I9.1; ALADR; Delta aminolevulinic acid dehydratase; Lv; OTTMUSP00000009376; RP24-189G18.9; aminolevulinate, delta-, dehydratase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALAD-26880TH Recombinant Human ALAD, His-tagged E.coli His
Human ALAD-428H Recombinant Human ALAD Protein, GST-tagged Wheat Germ GST
Human ALAD-54HCL Recombinant Human ALAD cell lysate N/A
Human ALAD-6108H Recombinant Human ALAD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALAD-512H Recombinant Human ALAD Protein, His-tagged E.coli His Met1~Glu330
Human ALAD-1387HF Recombinant Full Length Human ALAD Protein, GST-tagged In Vitro Cell Free System GST 339 amino acids
Mouse ALAD-1512M Recombinant Mouse ALAD Protein Mammalian Cell His
Mouse Alad-1588M Recombinant Mouse Alad Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ALAD-446M Recombinant Mouse ALAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALAD-446M-B Recombinant Mouse ALAD Protein Pre-coupled Magnetic Beads HEK293
Rat ALAD-609R Recombinant Rat ALAD Protein Mammalian Cell His
Rat ALAD-265R-B Recombinant Rat ALAD Protein Pre-coupled Magnetic Beads HEK293
Rat Alad-513R Recombinant Rat Alad Protein, His-tagged E.coli His Met1~Glu330
Rat ALAD-265R Recombinant Rat ALAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ALAD-292C Recombinant Cynomolgus ALAD Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ALAD-42C Recombinant Cynomolgus Monkey ALAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ALAD-42C-B Recombinant Cynomolgus Monkey ALAD Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ALAD-2413Z Recombinant Zebrafish ALAD Mammalian Cell His
Chicken ALAD-5496C Recombinant Chicken ALAD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALAD Related Articles

ALAD involved in several pathways and played different roles in them. We selected most pathways ALAD participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Porphyrin and chlorophyll metabolismEARS2;ALAS2;HMOX2;HCCSA.1;UGT5G1;HMBSA;BLVRB;UGT1A1;FECH
Metabolic pathwaysALDH1A2;CYP2P6;CMASA;PCXB;ALDH3A1;PTDSS1;TPI1A;TPH1B;GALNT10

ALAD has several biochemical functions, for example, catalytic activity, identical protein binding, lead ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAD itself. We selected most functions ALAD had, and list some proteins which have the same functions with ALAD. You can find most of the proteins on our site.

Function Related Protein
catalytic activityPPM1H;AZIN1A;TM9SF1;ACLYA;ALPI.2;ALDOCB;ISOC2;ALDH1L1;TKTB
identical protein bindingATL3;STAT6;MPST;SRI;HOMER1;PFKL;FRS3;PRPF19;BAG2
lead ion binding
porphobilinogen synthase activity
zinc ion bindingBRF1;SETMAR;EDEM3;ING4;ZCCHC4;TRIM30A;LIMS3L;RNF20;JUB

ALAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAD here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAD.

Alad; 15-deoxy-delta(12,14

Bardag-Gorce, F; French, SW; et al. Delta-aminolevulinic dehydratase is a proteasome interacting protein. EXPERIMENTAL AND MOLECULAR PATHOLOGY 91:485-489(2011).
Varadharajan, S; Sagar, BKC; et al. Localization of ferrochelatase in Plasmodium falciparum. BIOCHEMICAL JOURNAL 384:429-436(2004).
  • Q&As
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