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ALKBH1

  • Official Full Name

    alkB, alkylation repair homolog 1

  • Overview

    This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine.
  • Synonyms

    ALKBH1; alkB, alkylation repair homolog 1 (E. coli); alkB, alkylation repair homolog (E. coli) , ALKBH; alkylated DNA repair protein alkB homolog 1; ABH; alkB; hABH; DNA lyase ABH1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenas;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALKBH1-474H Recombinant Human ALKBH1 Protein, GST-tagged Wheat Germ GST
Human ALKBH1-8903HCL Recombinant Human ALKBH1 293 Cell Lysate HEK293 N/A
Human ALKBH1-2882H Recombinant Human ALKBH1 protein, His-tagged E.coli His 15 - 169 aa
Human ALKBH1-1198H Recombinant Human ALKBH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALKBH1-319H Recombinant Human ALKBH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALKBH1-223HFL Recombinant Full Length Human ALKBH1 Protein, C-Flag-tagged Mammalian cells Flag
Human ALKBH1-1445HF Recombinant Full Length Human ALKBH1 Protein, GST-tagged In Vitro Cell Free System GST 389 amino acids
Human ALKBH1-319H-B Recombinant Human ALKBH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALKBH1-1553M Recombinant Mouse ALKBH1 Protein Mammalian Cell His
Mouse Alkbh1-3273M Recombinant Mouse Alkbh1, His-tagged E.Coli or Yeast His 389
Mouse ALKBH1-473M-B Recombinant Mouse ALKBH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALKBH1-473M Recombinant Mouse ALKBH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Alkbh1-1599M Recombinant Mouse Alkbh1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish ALKBH1-2853Z Recombinant Zebrafish ALKBH1 Mammalian Cell His
Chicken ALKBH1-3196C Recombinant Chicken ALKBH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALKBH1 involved in several pathways and played different roles in them. We selected most pathways ALKBH1 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Breast Cancer PathwayUBE2F;GRN;GDI1;ANXA1;DCAKD;CYP19A1;C21orf7;ALKBH1;CCNB1IP1

ALKBH1 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity, ferrous iron binding, methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH1 itself. We selected most functions ALKBH1 had, and list some proteins which have the same functions with ALKBH1. You can find most of the proteins on our site.

Function Related Protein
DNA-(apurinic or apyrimidinic site) lyase activityHMGA1;APLF;HMGA1-RS1;NTHL1;HMGA1B;APEX1;APEX2;ALKBH1;HMGA1A
ferrous iron bindingBCO1;FECH;ISCA1;HAAO;ISCUB;ALKBH1;TRR1;EGLN2;PLOD1
methylcytosine dioxygenase activityALKBH1;TET2;TET1;TET3

ALKBH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH1.

  • Q&As
  • Reviews

Q&As (17)

Ask a question
How does ALKBH1 participate in DNA base repair and oxidative stress? 06/16/2022

ALKBH1 can remove oxidative components and methylation markers from DNA, and is involved in DNA base repair and oxidative stress.

How to evaluate the expression and role of ALKBH1 in liver cancer? 12/23/2021

By studying the expression and function of ALKBH1 in liver cancer tissue, we can understand its role in the treatment of liver cancer.

In which tissues is ALKBH1 expressed? 11/25/2021

ALKBH1 is mainly expressed in liver, spleen, myocardium and other tissues.

What is the role of ALKBH1 in the occurrence and development of gastric cancer? 11/01/2021

ALKBH1 plays a key role in the development and progression of gastric cancer, which may be related to the regulation of DNA repair and apoptosis.

What is the significance of changes in ALKBH1 expression for the prediction of metabolic diseases? 09/08/2021

The study on the expression level of ALKBH1 in metabolic diseases can provide new ideas for the prediction and treatment of metabolic diseases.

How does ALKBH1 affect the immune system and inflammatory response? 04/17/2021

It can influence the function of the immune system and the occurrence of inflammatory responses, regulating cell state by removing oxidative components and methylation markers.

What is the role of ALKBH1 in nervous system and related diseases? 04/14/2021

It has been shown to play an important role in neurological and related disorders, including mild cognitive impairment.

Is ALKBH1 expression regulated by environmental factors and endogenous signals? 03/16/2021

The expression may be regulated by various environmental factors and endogenous signals, including chemical stimulation and oxidative stress.

What is the role of ALKBH1 in DNA damage repair? 02/08/2021

ALKBH1 plays a key role in DNA damage and repair, repairing 1- or 3-methyladenine in DNA.

What is the role of ALKBH1 in cardiovascular disease? 12/01/2020

This protein plays an important role in the occurrence and development of cardiovascular diseases, which may be related to lipid metabolism and pathway regulation.

Which method does ALKBH1 in mammalian stem cell reprogramming? 09/29/2020

ALKBH1 plays an important role in mammalian stem cell reprogramming, promoting stem cell proliferation and differentiation.

Which effect of ALKBH1 mutation on metabolic capacity? 08/22/2020

The mutation may affect metabolic capacity and cause liver disease, diabetes, obesity and other related diseases.

How does ALKBH1 participate in DNA methylation repair? 04/17/2020

It can remove 1- or 3-methyladenine from DNA and is involved in DNA methylation repair and DNA repair processes.

What diseases are ALKBH1 mutations associated with? 03/12/2020

The mutation may be associated with cancer, cardiovascular disease, liver disease, etc.

What is the enzyme activity mechanism of ALKBH1? 01/18/2020

ALKBH1 repairs DNA damage by removing 1- or 3-methyladenine from DNA double-stranded DNA in an oxygen-dependent manner.

How to study the expression and role of ALKBH1 in certain diseases? 06/14/2019

The expression and role of ALKBH1 in certain diseases can be comprehensively evaluated through comparative omics, immunopathology, molecular biology and other research methods, so as to provide references for disease prediction and treatment.

Which cell signal transduction pathways does ALKBH1 participate in? 06/10/2019

ALKBH1 is involved in a variety of cell signaling pathways, including NF-κB.

Customer Reviews (4)

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Reviews
12/17/2020

    Can meet the specific experimental requirements and research purposes when used in experiments.

    05/16/2020

      The products are available in a wide range of specifications for different sizes and experimental designs.

      04/18/2020

        When ALKBH1 was used in the experiment, clear and consistent results could be obtained, which was convenient for data analysis and interpretation.

        12/24/2019

          Long half-life and is able to maintain stability and reliability during the experiment.

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