ALPL
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Official Full Name
alkaline phosphatase, liver/bone/kidney
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Overview
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described. -
Synonyms
ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Calf
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- Calf Intestine
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Liver
- Human placenta
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Myc
- DDK
- Fc
- Flag
- GST
- His (Fc)
- Avi
- His|SUMO
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ALPL Related Articles
- ALPL Related Research Area
ALPL involved in several pathways and played different roles in them. We selected most pathways ALPL participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Folate biosynthesis | GCH1;DHFR;SPR;QDPRA;ALPP;PTS;ALPI.1;QDPRB1;QDPR |
Metabolic pathways | PET112L;AZIN2;PLCZ1;CYP2B19;GALC;B3GALT2;RDH8B;COX4I2;GBE1 |
ALPL has several biochemical functions, for example, alkaline phosphatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPL itself. We selected most functions ALPL had, and list some proteins which have the same functions with ALPL. You can find most of the proteins on our site.
Function | Related Protein |
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alkaline phosphatase activity | ALPI;ALP3;ALPL;ALPPL2;ALPI.1;ALPP |
metal ion binding | ZNF763;TERT;CEPT1;TAF1B;FBXO30A;CLCNKB;ZNF548;ZFP536;CYB5A |
protein binding | GPI1;ADRA2B;SPRR2E;EBF1;TMEM14C;HIST1H1A;MTAP1B;BLOC1S2;NDFIP2 |
pyrophosphatase activity | PHOSPHO1;ALPL;CANT1A;DOM3Z;GMPS;CANT1B;PRUNE2;NUDT19 |
ALPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPL here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPL.
MAP3K14; TRAF2; TRAF3; EIF4A2; lrp; NFKBIA; RELA
- Q&As
- Reviews
Q&As (10)
Ask a questionALPL exhibits tissue-specific expression, with high levels in mineralizing tissues such as bones and teeth, but lower levels in other organs.
ALPL activity and expression undergo dynamic changes during development and aging, reflecting the physiological demands for mineralization.
ALPL activity can be modulated by factors such as pyrophosphate, calcium, and inhibitors like levamisole, which impact mineralization outcomes.
ALPL plays a critical role in mineralization processes by generating inorganic phosphate, an essential component of hydroxyapatite crystals in bones and teeth.
ALPL can serve as a diagnostic marker for hypophosphatasia and related mineralization disorders, and therapeutic strategies targeting ALPL are being explored.
ALPL deficiency or dysregulation is associated with hypophosphatasia, a genetic disorder characterized by impaired mineralization and skeletal abnormalities.
Genetic variations or mutations in the ALPL gene can lead to altered enzyme activity, affecting mineralization and contributing to disease phenotypes.
Manipulating ALPL activity and function holds promise for promoting bone regeneration and dental tissue engineering, enhancing mineralization processes and tissue formation.
ALPL regulates molecular interactions and signaling pathways, including Wnt/尾-catenin, BMP, and FGF signaling, to orchestrate mineralization processes.
ALPL gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in skeletal development and mineralization.
Customer Reviews (3)
Write a reviewEfficient target protein purification.
Reliable antibody for Western blotting.
Robust enzyme activity measurement.
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