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ALX3

  • Official Full Name

    ALX homeobox 3

  • Overview

    This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this genes promoter is associated with advanced-stage neuroblastoma tumors.
  • Synonyms

    ALX3; ALX homeobox 3; aristaless like homeobox 3; homeobox protein aristaless-like 3; ALX 3; Homeobox protein aristaless like 3; MGC138212; MGC141988; Proline rich transcription factor ALX3; OTTHUMP00000013372; aristaless-like homeobox 3; proline-rich transcription factor ALX3; FND1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E. coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALX3-510H Recombinant Human ALX3 protein, GST-tagged Wheat Germ GST
Human ALX3-1991H Recombinant Human ALX3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ALX3-1368H Recombinant Human ALX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALX3-511H Recombinant Human ALX3 protein, GST-tagged E. coli GST 1-152 aa
Mouse ALX3-1582M Recombinant Mouse ALX3 Protein Mammalian Cell His
Mouse ALX3-495M Recombinant Mouse ALX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALX3-495M-B Recombinant Mouse ALX3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Alx3-589M Recombinant Mouse Alx3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALX3 Related Articles

ALX3 involved in several pathways and played different roles in them. We selected most pathways ALX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ALX3 has several biochemical functions, for example, DNA binding, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALX3 itself. We selected most functions ALX3 had, and list some proteins which have the same functions with ALX3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPC;SRFB;PEG10;FOXF2A;PCXA;NFIL3;HOXD9A;ZFP526;EME1
sequence-specific DNA bindingHSF5;FOXD1;DMRT3;LMX1BB;FOXP4;SOX2;NANOG;DLX2B;ATF4B1
transcription factor activity, sequence-specific DNA bindingZNF354B;TBX5B;HOXB8A;ZSCAN4C;DLX2;RFXAP;INSM1A;ZNF234;PBX3B

ALX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALX3.

Fernandez-Perez, A; Vallejo, M; et al. Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. BIOCHEMICAL JOURNAL 463:287-296(2014).
Liu, WB; Han, F; et al. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer. INTERNATIONAL JOURNAL OF CANCER 134:1311-1322(2014).
  • Q&As
  • Reviews

Q&As (10)

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How is ALX3 expression regulated during embryonic development, particularly in tissues where it plays a critical role? 12/02/2022

ALX3 expression is regulated spatially and temporally during embryonic development, with specific patterns in tissues such as the neural tube, limb buds, or craniofacial structures.

Can ALX3 be targeted pharmacologically or genetically to modulate its activity, and what are the potential therapeutic implications? 11/16/2020

Pharmacological or genetic modulation of ALX3 activity may have therapeutic implications for developmental disorders or regenerative medicine, but further studies are needed to explore these possibilities.

What are the DNA binding motifs recognized by ALX3, and how do they contribute to its transcriptional regulatory activity? 11/08/2020

ALX3 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.

How does ALX3 interact with other transcription factors and co-regulators to form transcriptional complexes that control gene expression and cellular fate during embryonic development? 03/15/2020

ALX3 forms transcriptional complexes with other transcription factors and co-regulators, such as PAX6 or DLX5, to coordinate gene expression programs essential for embryonic development and tissue morphogenesis.

What are the epigenetic modifications associated with ALX3 binding sites and how do they modulate ALX3-mediated transcriptional regulation? 12/26/2019

ALX3 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX3-mediated transcriptional activity.

What are the protein-protein interactions of ALX3 and how do these interactions contribute to its function? 12/13/2018

ALX3 interacts with co-regulatory proteins and other transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.

What are the downstream targets of ALX3, and how does it regulate gene expression to influence cellular processes during embryogenesis? 04/28/2018

ALX3 regulates the expression of genes involved in cell fate determination, tissue patterning, and morphogenesis during embryogenesis, including those encoding transcription factors, extracellular matrix components, or signaling molecules.

How does ALX3 interact with signaling pathways involved in tissue development, such as Wnt, BMP, or FGF signaling? 01/10/2018

ALX3 integrates with signaling pathways, including Wnt, BMP, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.

How does ALX3 regulate cell proliferation, differentiation, and migration during embryogenesis, and what are the underlying molecular mechanisms? 07/22/2017

ALX3 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.

What are the effects of ALX3 gain-of-function or loss-of-function mutations on embryonic development, and how do they affect cellular behaviors and tissue morphogenesis? 03/06/2017

Gain-of-function or loss-of-function mutations in ALX3 can disrupt normal embryonic development, leading to craniofacial malformations, limb abnormalities, or neural tube defects.

Customer Reviews (3)

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Reviews
04/20/2020

    Accurate measurement of protein-protein complex stoichiometry.

    12/31/2019

      Compatible with high-content imaging platforms.

      11/16/2017

        Reduced assay variability for reliable data interpretation.

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