AMBN
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Official Full Name
ameloblastin (enamel matrix protein)
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Overview
This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. -
Synonyms
AMBN; ameloblastin (enamel matrix protein); ameloblastin, enamel matrix protein; ameloblastin; AMBN_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AMBN Related Articles
AMBN involved in several pathways and played different roles in them. We selected most pathways AMBN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AMBN has several biochemical functions, for example, growth factor activity, structural constituent of tooth enamel. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBN itself. We selected most functions AMBN had, and list some proteins which have the same functions with AMBN. You can find most of the proteins on our site.
Function | Related Protein |
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growth factor activity | TIMP1;FIGF;Kitl;GDF6B;MSTNB;ANGPTL3;VEGFAB;GDF9;PDGFA |
structural constituent of tooth enamel | AMELY;AMBN;STATH;TUFT1;AMELX |
AMBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBN here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBN.
- Q&As
- Reviews
Q&As (10)
Ask a questionAMBN expression patterns and levels can serve as biomarkers for enamel defects or dental disorders, providing diagnostic information about the integrity and quality of the enamel layer.
AMBN-derived peptides or fragments may have potential as therapeutic agents for enamel repair or regeneration, promoting enamel formation or stimulating the differentiation of dental stem cells.
AMBN contributes to the mechanical properties of enamel, such as its hardness, resilience, and resistance to wear, through its organization and interaction with other enamel proteins.
Mutations or genetic variations in the AMBN gene can lead to enamel defects and dental phenotypes, highlighting the importance of AMBN in enamel formation and integrity.
AMBN undergoes post-translational modifications, including phosphorylation and glycosylation, which play a role in its functional properties and assembly into the developing enamel matrix.
The secretion and transport of AMBN to the enamel matrix involve specific mechanisms, including vesicular trafficking and protein-protein interactions, which can be targeted for therapeutic interventions in enamel-related disorders.
AMBN interacts with dental stem cells or progenitor cells, influencing their differentiation and contributing to tooth regeneration or repair processes.
The expression and secretion of AMBN during tooth development are regulated by various signaling pathways, including those involving transcription factors, growth factors, and extracellular matrix components.
AMBN interacts with other enamel matrix proteins, such as amelogenin and enamelin, forming a complex network that contributes to the formation of the enamel matrix and its subsequent mineralization.
AMBN is a critical protein involved in enamel development and is responsible for regulating enamel mineralization and determining the structure and hardness of the enamel layer.
Customer Reviews (3)
Write a reviewReduced assay interference from complex sample backgrounds.
High-throughput screening compatibility for rapid data generation.
Reliable detection of protein localization and trafficking.
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