AMD1
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Official Full Name
adenosylmethionine decarboxylase 1
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Overview
S-adenosylmethionine decarboxylase (AMD1) is an important enzyme in amine and polyamine biosynthesis. AMD1 catalyses the formulation of S-adenosylmethioninamine from S-adenosyl-L-methionine. -
Synonyms
AMD1; adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme; SAMDC; S-adenosylmethionine decarboxylase 1; AMD; ADOMETDC; FLJ26964; DKFZp313L1234;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- AMD1 Related Articles
AMD1 involved in several pathways and played different roles in them. We selected most pathways AMD1 participated on our site, such as Cysteine and methionine metabolism, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | MAT1A;MRI1;CDO1;LDHBA;DNMT1;LDHAL6B;MDH1AA;GOT2;CBSA |
| Arginine and proline metabolism | CKMA;NOS2;MAOB;AZIN2;ODC1;CKBB;CKMT1B;SMS;LSM1 |
| Metabolic pathways | TPI1B;H6PD;NDST1;DOLK;NT5C3L;POLR2K;ENPP3;PCYT1AB;IMPDH1A |
AMD1 has several biochemical functions, for example, adenosylmethionine decarboxylase activity, putrescine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMD1 itself. We selected most functions AMD1 had, and list some proteins which have the same functions with AMD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenosylmethionine decarboxylase activity | AMD2;AMD1 |
| putrescine binding | AMD2;AMD1 |
AMD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMD1.
HSPB1
- Q&As
- Reviews
Q&As (10)
Ask a questionAMD1 interacts with other enzymes, such as ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC), in the polyamine biosynthetic pathway, forming a regulatory network.
Alterations in AMD1 expression or activity have been observed in various diseases, including cancer, suggesting its potential as a diagnostic marker or therapeutic target for specific conditions.
AMD1 expression is regulated at the transcriptional level by various factors, including growth factors, hormones, and cellular stressors.
AMD1 represents a potential pharmacological target for modulating polyamine metabolism, and its inhibition has been explored as a therapeutic strategy in diseases such as cancer.
AMD1 deficiency or inhibition can lead to altered polyamine levels and impaired cellular processes, including reduced cell proliferation and compromised cell survival.
AMD1 plays a key role in polyamine biosynthesis, regulating the levels of polyamines such as putrescine, spermidine, and spermine, which are involved in cell growth, proliferation, and differentiation.
AMD1 is an enzyme that catalyzes the conversion of S-adenosylmethionine (SAM) to decarboxylated SAM, which is a crucial step in the biosynthesis of polyamines.
The catalytic activity and substrate specificity of AMD1 are determined by its unique protein structure, including active site residues and cofactor binding sites.
AMD1 activity influences downstream signaling pathways, including mTOR signaling, DNA methylation, and gene expression, which are involved in cell growth and proliferation.
The substrates of AMD1 include SAM, the primary methyl donor in cellular methylation reactions, and its decarboxylated product, which serves as a precursor for polyamine synthesis.
Customer Reviews (3)
Write a reviewCompatibility with high-resolution imaging techniques for detailed analysis.
Accurate measurement of protein turnover rates.
Reduced non-specific binding in antibody-based assays.
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