AP1S1
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Official Full Name
adaptor-related protein complex 1, sigma 1 subunit
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Overview
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. -
Synonyms
AP1S1; adaptor-related protein complex 1, sigma 1 subunit; CLAPS1; AP-1 complex subunit sigma-1A; AP 1 complex subunit sigma 1A; AP19; clathrin assembly protein complex 1 sigma 1A small chain; clathrin coat assembly protein AP19; clathrin associated/assembly/adaptor protein; small 1 (19kD); golgi adaptor HA1/AP1 adaptin sigma 1A subunit; HA1 19 kDa subunit; SIGMA1A; sigma1A subunit of AP 1 clathrin adaptor complex; sigma1A adaptin; WUGSC:H_DJ0747G18.2; Adapter related protein complex 1 sigma 1A subunit; Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP1 sigma 1A subunit; AP1 complex subunit sigma 1A; AP1S1_HUMAN; Clathrin assembly protein complex 1 sigma-1A small chain; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; Sigma 1a subunit of AP-1 clathrin; Sigma 1a subunit of AP1 clathrin; Sigma adaptin 1A; Sigma-adaptin 1A; Sigma1A-adaptin; sigma1A subunit of AP-1 clathrin adaptor complex; clathrin-associated/assembly/adaptor protein, small 1 (19kD);
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | AP1S1-649H | Recombinant Human AP1S1 protein, GST-tagged | Wheat Germ | GST |
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| Human | AP1S1-8817HCL | Recombinant Human AP1S1 293 Cell Lysate | HEK293 | N/A |
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| Human | AP1S1-184H | Recombinant Human AP1S1 Protein, His-tagged | E.coli | N-His | Met1-Ala158 |
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| Human | AP1S1-24HF | Recombinant Full Length Human AP1S1 Protein | In Vitro Cell Free System | 133 amino acids |
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| Human | AP1S1-27354TH | Recombinant Human AP1S1 | Wheat Germ | N/A | 133 amino acids |
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| Human | AP1S1-1036HF | Recombinant Full Length Human AP1S1 Protein, GST-tagged | In Vitro Cell Free System | GST | 133 amino acids |
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| Mouse | AP1S1-1735M | Recombinant Mouse AP1S1 Protein | Mammalian Cell | His |
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| Mouse | Ap1s1-3529M | Recombinant Mouse Ap1s1, His-tagged | E.Coli or Yeast | His | 158 |
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| Mouse | AP1S1-598M-B | Recombinant Mouse AP1S1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | AP1S1-598M | Recombinant Mouse AP1S1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | AP1S1-10638Z | Recombinant Zebrafish AP1S1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AP1S1 Related Articles
AP1S1 involved in several pathways and played different roles in them. We selected most pathways AP1S1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | ITPR2;KIR2DS2;CD300LB;SPSB4;CLEC2H;KLRB1A;CTSB;CLEC2D;RASGRP1 |
| Clathrin derived vesicle budding | AP3S1;SNX9A;YIPF6;GAK;PUM1;DTNBP1B;HIP1R;BLOC1S6;TPD52 |
| Disease | VPS37A;FDX1L;EEF2;GCKR;JAG2;HDAC5;CUX1;RPL35;CFTR |
| Golgi Associated Vesicle Biogenesis | AP1B1;TPD52L1;AP1S3A;AP1G1;HIP1RB;TPD52;PICALM;NAPAB;PICALMB |
| HIV Infection | VPS37A;PACS1;APOBEC3G;TCEB3;AP1B1;PSIP1;NPM1;TAF1L;SSRP1 |
| Host Interactions of HIV factors | PSIP1;RCC1;AP1G1;AP1S1;DOCK2;PACS1;AP1M2;PPIAL4A;AP1B1 |
| Immune System | TRIM50;IFIT12;CNPY3;BTR06;DEFB125;CD207;PANX1A;LAIR1;DDX41 |
| Infectious disease | ANTXR1;PDCD6IP;CHMP4B;CCDC167;DOCK2;ANTXR2;KPNA5;RCC1;STX1B |
AP1S1 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1S1 itself. We selected most functions AP1S1 had, and list some proteins which have the same functions with AP1S1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein transporter activity | KPNA2;IPO9;SOSTDC1B;AP1S3;DPY19L2;XPO1;CALCRL;AP1S3B;KPNB3 |
AP1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1S1.
AP1B1; Ap1g1; SLC16A1; AP1S2; RAB10; SEC61A1; IKBKE; ARMC6; EBLN2; pi3p; GTSE1
- Q&As
- Reviews
Q&As (19)
Ask a questionAt present, AP1S1 is mainly used in the therapeutic field, and has not been widely used in the preparation of diagnostic reagents.
Previous studies have shown that AP1S1 has potential application value in tumor therapy, and the specific application needs further study.
As an immunomodulator, AP1S1 is expected to become a new immunotherapy strategy to help patients fight cancer, viruses and other diseases.
Yes, AP1S1 can be used as an adjunct therapeutic means, combined with radiotherapy, chemotherapy and other therapeutic means to improve the therapeutic effect.
AP1S1 gene is involved in important biological processes such as intracellular signaling and cargo transport, and has a certain relationship with tumor invasion and metastasis.
The AP1S1 can enhance the immune response of the body and has a good therapeutic potential for viral infection.
Recombinant protein AP1S1 can regulate the immune response in the tumor microenvironment and play an anti-tumor role.
The production technology of AP1S1 has been relatively mature, and some pharmaceutical companies have begun large-scale production.
According to existing studies, AP1S1 may have application prospects in tumor, autoimmune disease, viral infection, etc.
AP1S1 as a protein drug needs to be injected, and oral method is not practical.
The quality of AP1S1 should meet certain standards of purity, activity, stability, non-toxicity, no bacterial contamination and so on.
AP1S1 can play an important role in antiviral, anti-tumor and immune response regulation by interfering with intracellular cargo transport mechanisms, and is expected to become a new therapeutic means.
AP1S1 is involved in the transport of substances between the endoplasmic reticulum and the Golgi apparatus, intracellular signaling and cytoskeleton formation and other biological processes.
Recombinant AP1S1 has not been shown to have a tumor preventive effect.
Recombinant AP1S1 can regulate the overactivation of the immune response in patients with autoimmune disease and reduce symptoms.
Recombinant AP1S1 protein can enhance immune response and enhance immunovirulence by interfering with cargo transport and other mechanisms.
There are two common methods for preparing AP1S1 : prokaryotic expression system and mammalian expression system.
Antibody gene therapy targets specific tumor targets, while recombinant AP1S1 exerts its role by regulating immune responses and interfering with cargo transport.
Recombinant AP1S1 can inhibit the expression of a series of pro-inflammatory cytokines and play an anti-inflammatory role.
Customer Reviews (6)
Write a reviewThe production process focuses on the recycling of resources, and the waste is reused, reducing the consumption of natural resources.
Background of AP1S1 in Western blot was very clean and showed good antibody specificity.
Under different experimental conditions, the stability of AP1S is still very good, indicating that it has a wide range of applications and adaptability.
Reproducibility of AP1S1 is very good, and I can get consistent results from each experiment, which makes me more confident in the experimental results.
The short half-life and high clearance characteristics of AP1S1 make it better adapted to the needs of clinical treatment, and provide patients with safer and more effective treatment options.
The short half-life and high clearance characteristics of AP1S make it able to effectively avoid drug accumulation and side effects, and provide a strong guarantee for the health of patients.
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