AP3M1
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Official Full Name
adaptor-related protein complex 3, mu 1 subunit
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Overview
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed. -
Synonyms
AP3M1; adaptor-related protein complex 3, mu 1 subunit; AP-3 complex subunit mu-1; Adapter-related protein complex 3 mu-1 subunit; AP-3 adapter complex mu3A subunit; AP3M1_HUMAN; CLATHRIN ADAPTOR COMPLEX AP3; Mu-adaptin 3A; mu3A; Mu3A-adaptin; clathrin adaptor complex AP3, mu-3A subunit;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AP3M1-9722H | Recombinant Human AP3M1, GST-tagged | E.coli | GST | C-term-200a.a. | |
| Human | AP3M1-657H | Recombinant Human AP3M1 protein, GST-tagged | Wheat Germ | GST |
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| Human | AP3M1-190H | Recombinant Human AP3M1 Protein, His-tagged | E.coli | N-His | Met1-Val247 |
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| Human | AP3M1-1221HF | Recombinant Full Length Human AP3M1 Protein, GST-tagged | In Vitro Cell Free System | GST | 418 amino acids |
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| Mouse | AP3M1-1746M | Recombinant Mouse AP3M1 Protein | Mammalian Cell | His |
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| Mouse | AP3M1-606M | Recombinant Mouse AP3M1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | AP3M1-606M-B | Recombinant Mouse AP3M1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Ap3m1-3541R | Recombinant Rat Ap3m1, His-tagged | E.Coli or Yeast | His | 418 |
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| Zebrafish | AP3M1-11440Z | Recombinant Zebrafish AP3M1 | Mammalian Cell | His |
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| Chicken | AP3M1-2889C | Recombinant Chicken AP3M1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
AP3M1 involved in several pathways and played different roles in them. We selected most pathways AP3M1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP3M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | ATP6V0A4;ASAH1B;LGMN;ABCB9;CD164;ASAH1;CTSSA;HEXA;ACP5A |
AP3M1 has several biochemical functions, for example, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP3M1 itself. We selected most functions AP3M1 had, and list some proteins which have the same functions with AP3M1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | RAB11FIP1;RAB11FIP4B;TMEM127;MICALL1;STX4A;SGSM2;RAB3GAP1;SLC6A4;RAB11FIP2 |
| protein binding | RASSF9;PIPOX;BRAP;NEDD4;OAS2;LASP1;CSTF2T;DDX39B;SPOP |
AP3M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP3M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP3M1.
CRMP1; AGTRAP; TRIM9; SIPA1L2; RSPH14; WDR48; mnmC; pi3p
- Q&As
- Reviews
Q&As (20)
Ask a questionAccording to the current study, the therapeutic effect of AP3M1 may be dose-dependent, but the specific dose-effect needs to be further studied.
What makes AP3M1 special compared to other s may include its specific biological function and clinical application potential.
The study of AP3M1 is a long and complex process, and the specific time depends on several factors, including research progress and clinical trial progress.
The production cost of AP3M1 may be affected by many factors, including production technology, purification method, etc.
The potential of recombinant AP3M1 in cancer therapy is being studied, but it has not yet been determined whether it can be used as an effective means of cancer treatment.
The AP3M1 may have potential in drug delivery systems, but the specific applicability and advantages need to be further studied.
The research status of AP3M1 is a frontier subject, which is currently undergoing basic research and clinical trials.
Recombinant protein AP3M1 may be involved in immune system regulation, but the specific mechanism needs to be further studied.
Oral administration of AP3M1 may have certain challenges and limitations, and the specific applicability needs to be further studied.
Potential clinical applications of recombinant AP3M1 may include the treatment of certain genetic diseases, cancer immunotherapy, etc.
The recombinant AP3M1 protein may interact with the patient's immune system, but the specific mechanism needs to be further studied.
Potential applications of recombinant AP3M1 include the treatment of autoimmune diseases, but the specific effects need to be further studied.
It is not known whether there are side effects of recombinant AP3M1 therapy, and further research and clinical trials are needed to determine its safety and side effects.
It has not yet been determined whether the deficiency of AP3M1 contributes to the development of certain diseases, and further research is needed.
At present, it is not known whether the drugs already on the market contain AP3M1 , and further inquiries may be required.
The biosynthesis of AP3M1 may include genetic engineering techniques, expressed and purified by transgenic cells or bioreactors.
The application of AP3M1 is protected by intellectual property rights, which needs to be verified, but generally involves new drug applications with some protection.
Evaluation of the biological activity of AP3M1 may include in vitro and animal model experiments.
At present, data on the safety and efficacy of recombinant AP3M1 in clinical trials have not been made public, and clinical trials are still required to determine it.
The AP3M1 may be used in the diagnosis of some diseases, but the specific scope of application needs further research.
Customer Reviews (3)
Write a reviewI appreciate the quality of AP3M1 manufacturer, and their product repeatability is very good, which makes me more confident in the experimental results.
The stability of AP3M1 is so good that it can be performed experimentally for a long time without affecting its performance and results.
After using AP3M1, the repeatability of Western blot was significantly improved.
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