Apaf1
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Official Full Name
APAF1 apoptotic peptidase activating factor 1
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Overview
Apaf-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (Apaf-2). The resulting Apaf-1/cytochrome c complex associates with the zymogen form of caspase-9 (Apaf-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody will be useful in studies of the activation of caspases through Apaf-1 and also in metastatic melanomas where Apaf-1 is inactivated which leads to defects in the execution of apoptotic cell death. -
Synonyms
APAF1; apoptotic peptidase activating factor 1; apoptotic peptidase activating factor , apoptotic protease activating factor; apoptotic protease-activating factor 1; APAF 1; CED4; APAF-1; DKFZp781B1145;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|T7
- B2M
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Apaf1 Related Articles
- Apaf1 Related Signal Pathway
Apaf1 involved in several pathways and played different roles in them. We selected most pathways Apaf1 participated on our site, such as p signaling pathway, Apoptosis, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Apaf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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p signaling pathway | GADD45AA;EI24;APAF1;Casp3;CCNB2;ZMAT3;RRM2B;PPM1DB;MDM4 |
Apoptosis | IRF2A;HIST1H1C;XIAP;PIK3R2;PIK3CG;IL1A;PIK3R1;FADD;PLEC |
Alzheimers disease | ATP5H;CHP;NDUFB3;COX8A;ATP5C1;COX7C;NDUFV1;UQCRC1;BACE2 |
Parkinsons disease | COX7A2L;NDUFS5;PINK1;SNCA;COX8C;NDUFB2;UQCRC1;ATP5B;SDHB |
Amyotrophic lateral sclerosis (ALS) | GRIN2B;Casp3;BID;CCS;TNFRSF1A;APAF1;RAC1;MAP3K5;MAPK11 |
Huntingtons disease | COX6A2;NDUFV2;GRM5;UQCRFS1;COX7B2;BAX;POLR2H;DNALI1;NDUFA6 |
Legionellosis | RAB1A;EEF1G;RAB1;CASP1;NAIP6;CYCS;CASP8;NFKB1;ITGAM |
Tuberculosis | CLEC7A;TNF;FCGR2A;HLA-DRA;HLA-DMA;PPP3CB;TLR9;MAPK12;CAMK2A |
Hepatitis B | NFKBIA;IFIH1;IL6;IFNA16;PIK3R5;BAD;TLR3;IFNA6;PTK2B |
Small cell lung cancer | PIK3R3;LAMB1;RELA;CKS2;LAMB4;LAMC2;TRAF2;AKT1;CASP9 |
Apaf1 has several biochemical functions, for example, ADP binding, ATP binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Apaf1 itself. We selected most functions Apaf1 had, and list some proteins which have the same functions with Apaf1. You can find most of the proteins on our site.
Function | Related Protein |
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ADP binding | MIEF1;GLUD2;PRPS1;ABCG1;CYB5R3;CHORDC1;ATP1A1;VCP;TAP1 |
ATP binding | EPHA4A;MYH15;ZAK;P2RX4B;NLRP9C;RET;SNRKB;MYO1H;MLKL |
cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1;NLRP12;PYCARD;CTSH;NLRP1;CASP1;BAD;MAPK9;APAF1 |
heat shock protein binding | PPP5C;BAK1;PARK2;PDXP;DNAJA3;DAXX;APAF1;LIMK1;HSPA1L |
identical protein binding | LEPR;RYR2;TRIP10;NPR2;CCL4;SLK;PKD2L1;LECT2;SNCAIP |
nucleotide binding | ATP2B3A;PIP5K2;GLULB;CAMK2D2;SR140;PRKCBB;SREK1;IMPDH2;Fert2 |
protein binding | SPAT-1;RPS3;SRGN;LCMT1;SMARCAL1;STOML2;SMN1;ZBTB32;STK10 |
Apaf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Apaf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Apaf1.
CASP9
- Q&As
- Reviews
Q&As (20)
Ask a questionRecombinant APAF1 protein is an important apoptosis-promoting factor that can play a key role in programmed apoptosis.
APAF1 is almost non-toxic side effects, will not cause great harm to the human body.
Recombinant APAF1 protein cannot completely replace existing anti-tumor drugs, but it can be used as an important part of comprehensive tumor therapy, which plays an important role in improving the therapeutic effect and reducing the toxic side effects of dose.
The latest research shows that the APAF1 can be used as a target of novel tumor immunotherapy, and has a good effect on tumor treatment.
Recombinant APAF1 protein plays an important role in human endoplasmic reticulum stress response and can protect the maintenance of endoplasmic reticulum function by inhibiting apoptosis.
APAF1 can be prepared by gene recombination technology, which first expresses the target protein in a large number of expression hosts such as bacteria, and then obtains high purity APAF1 through purification technology.
APAF1 is widely distributed in the human body, expressed not only in tumor cells, but also in many tissues such as heart, liver, and stomach.
APAF1 can be used in early diagnosis of tumor, prognosis of tumor, and monitoring of tumor therapeutic effect.
The APAF1 has a clear recognition ability for electron microscopy photos, and can be used to observe the effect of specific cells and gene transformations.
APAF1 and p53 are closely related in the activation and regulation of apoptosis pathway.
Yes, small molecule compounds have regulatory effects on the expression and activity of APAF1.
APAF1 is low in antigenicity, so it is not easy to produce an immune response.
Apoptosis resistance is a physical state in which tumor cells overcome the production of apoptotic signals. APAF1 can regulate apoptosis pathway and help to reduce apoptosis resistance.
Yes, the expression and activity level of APAF1 can be used as a standard for drug dose adjustment, which can play a regulatory role in the effect of tumor therapy.
Recombinant APAF1 protein plays an important role in the development of liver cancer and breast cancer, and can be used as a target for early diagnosis and treatment.
APAF1 in tumor resistance may be affected by some factors that can lead to the weakening of apoptotic pathway processes, thus affecting the efficacy of tumor therapy.
Yes, the recombinant APAF1 protein can be used to study the role and mechanism of apoptosis signaling pathway in tumorigenesis and development.
APAF1 can be used in Western blot kits, ELISA kits, Western blot kits, etc.
Yes, recombinant APAF1 protein in tumor therapy can be used to develop novel targeted therapeutic drugs, such as vaccines and immune checkpoint inhibitors.
PAF1 can bind to other apoptotic proteins such as cytochrome c to promote the activation of Karber gene and initiate the apoptotic mechanism.
Customer Reviews (4)
Write a reviewThis protein is really excellent, every time it is used, it maintains a very stable performance, which can be seen that its production process is very careful.
Short half-life and high clearance properties of AP5Z1 make it an even greater advantage in emergency situations where rapid therapeutic effect is needed.
Green production process of AP5Z1 is very environmentally friendly, from the selection of raw materials to the production process reflects the concept of green production, without any negative impact on the environment.
The repeatability of AP5Z1 can be said to be unmatched, and the results are very consistent in every experiment or application, which is an important reflection of its excellent quality.
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