APBB1
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Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
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Overview
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the;nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1;and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent;the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of;Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by;downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different;isoforms have been described for this gene. -
Synonyms
APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; MGC:9072;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APBB1-668H | Recombinant Human APBB1 protein, GST-tagged | Wheat Germ | GST | ||
Human | APBB1-8803HCL | Recombinant Human APBB1 293 Cell Lysate | HEK293 | N/A | ||
Human | APBB1-8804HCL | Recombinant Human APBB1 293 Cell Lysate | HEK293 | N/A | ||
Human | APBB1-33HF | Recombinant Full Length Human APBB1 Protein | In Vitro Cell Free System | 708 amino acids | ||
Human | APBB1-1655H | Recombinant Human APBB1 protein, His & T7-tagged | E.coli | His/T7 | Gly267~Phe528 (Accession # O00213) | |
Human | APBB1-28167TH | Recombinant Human APBB1 | Wheat Germ | N/A | 708 amino acids | |
Human | APBB1-2405H | Recombinant Human APBB1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | APBB1-1079HF | Recombinant Full Length Human APBB1 Protein, GST-tagged | In Vitro Cell Free System | GST | 708 amino acids | |
Mouse | APBB1-1757M | Recombinant Mouse APBB1 Protein | Mammalian Cell | His | ||
Mouse | APBB1-615M | Recombinant Mouse APBB1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Apbb1-622M | Recombinant Mouse Apbb1 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | APBB1-615M-B | Recombinant Mouse APBB1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Apbb1-199M | Recombinant Mouse Apbb1 Protein, His-tagged | E.coli | N-His | Pro182-Met412 | |
Rat | Apbb1-3437R | Recombinant Rat Apbb1, His-tagged | E.Coli or Yeast | His | 711 | |
Rat | APBB1-710R | Recombinant Rat APBB1 Protein | Mammalian Cell | His | ||
Rat | APBB1-366R | Recombinant Rat APBB1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | APBB1-366R-B | Recombinant Rat APBB1 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
APBB1 involved in several pathways and played different roles in them. We selected most pathways APBB1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alzheimers disease | NDUFA7;NDUFA10;NDUFC2;ATP5B;NDUFA1;APH1C;CALML3;NDUFV1;ATP5O |
APBB1 has several biochemical functions, for example, beta-amyloid binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB1 itself. We selected most functions APBB1 had, and list some proteins which have the same functions with APBB1. You can find most of the proteins on our site.
Function | Related Protein |
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beta-amyloid binding | FBXO2;MAPK8IP2;CD74;APBB2;CST3;BACE1;APBB3;ITM2C;LDLRAD3 |
chromatin binding | CBX7;SMARCC1;ARID3A;TCF7L1B;ATAD2;ING5;LMO2;HOXD10;BRD3 |
histone binding | MCM2;L3MBTL2;HIST2H3C1;HIST1H3G;ASF1B;WDTC1;SMARCA2;BRDT;NCAPD3 |
proline-rich region binding | BAIAP2;TCERG1;CYLD;CCND1;CSK;APBB1;RABAC1;GHR;FAM59A |
protein binding | RTN4RL2A;GGNBP2;PSMB4;KIAA0947;CSNK2B;TNFSF13B;SH2D1A;SHROOM2;PRDM7 |
transcription factor binding | HES4;REST;E2F1;TFDP1B;GTF2A2;PELP1;JUND;NCOA2;HEY1 |
APBB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB1.
APP; LRP1; APP; EGFR; ERBB2; CLSTN1; ANXA1; App; ATXN1
- Q&As
- Reviews
Q&As (19)
Ask a questionAPBB1 are involved in mitochondrial and Wnt signaling pathways.
Recombinant APBB1 protein is a transcription factor associated with biological processes such as protein breakdown, signaling, and the cell cycle. Its main function is to participate in the regulation of transcription and RNA stability.
Mutations in the APBB1 gene are thought to be a risk gene for certain cancers and diseases such as Alzheimer's disease.
The APBB1 gene is known to have multiple tailoring exons. In humans, there may be variable splicing of APBB1 gene.
There are currently no drugs on the market that target the APBB1. At the same time, some researchers are exploring molecules related to APBB1 to develop drugs to treat diseases associated with it.
APBB1 is involved in regulating the metabolism and transport of Alzheimer's disease-associated Aβ peptides and may be a therapeutic target for Alzheimer's disease.
The APBB1 has been studied in relation to many diseases, including Alzheimer's disease, cancer and cardiovascular disease.
APBB1 is highly expressed in tissues such as brain, heart and lung.
Variations in both the APBB1 gene and the APP gene are considered risk genes for Alzheimer's disease.
APBB1 is associated with the amyloid precursor protein metabolic pathway (APP).
The use of gene editing technology to study APBB1 to treat and prevent related diseases is a research hotspot in recent years.
APBB1 has been shown to be involved in a number of cell cycle and apoptosis pathways, so it may hold promise as a new target for cancer therapy.
There are currently no specific antibodies available for the detection of APBB1 .
Mutations in the APBB1 gene are thought to be associated with diseases such as cancer and Alzheimer's disease.
APBB1 is involved in signaling pathways in the occurrence and development of cardiovascular diseases such as myocardial hypertrophy and myocardial fibrosis.
APBB1 may be involved in the regulation of apoptosis.
APBB1 protein may act as a tumor inhibitor and participate in the regulation of cell cycle progression and apoptosis.
It has been shown that the impairment of cognitive function associated with Alzheimer's disease can be mitigated by regulating the APBB1.
At present, there are no studies to prove the mechanism of APBB1 promoting cardiovascular organ regeneration.
Customer Reviews (4)
Write a reviewAPBB1 they produce has strong anti-pollution ability and is safe to use.
Band position of APBB1 in Western blot was consistent with the expectation, showing good target recognition ability.
Catalytic activity of APBB1 is very strong, which can significantly improve the yield of chemical reactions and reduce costs, and its economic value is outstanding.
After using this APBB1, my experiment repeatability is very good, which is convenient for subsequent data analysis and experimental operation.
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