APEX1
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Official Full Name
APEX nuclease (multifunctional DNA repair enzyme) 1
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Overview
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. -
Synonyms
APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- HIS
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- T7
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- APEX1 Related Research Area
APEX1 involved in several pathways and played different roles in them. We selected most pathways APEX1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | POLE4;POLE;UNGA;POLD1;POLE3;SMUG1;nth;xthA;TDG |
APEX1 has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX1 itself. We selected most functions APEX1 had, and list some proteins which have the same functions with APEX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 exonuclease activity | RAD1;WRN;TREX1;ERI1;RAD9B;POLE;REXO2;EXOSC10;APLF |
| DNA binding | FOXO3B;IRF2;PPARAA;TBX6;HIST1H111L;ZNF32;HDX;HIST1H2BG;IGHMBP2 |
| DNA-(apurinic or apyrimidinic site) lyase activity | NEIL1;HMGA1B;HMGA2;APLF;ALKBH1;APEX2;HMGA1-RS1;NEIL2;NTHL1 |
| RNA-DNA hybrid ribonuclease activity | FEN1;RNASEH1;APEX1;RNASEH2C;RNASEH2A;RNASEH2B;EXO1 |
| chromatin DNA binding | RXRA;CLOCK;ZIC2;SLAMF7;RELA;HIST1H1D;XBP1;HIST1H1A;H2AFZ |
| damaged DNA binding | CRY2;REV1;HMGB1;BRCA1;XPA;RPS3;RAD23B;TRP63;TP63 |
| double-stranded DNA 3-5 exodeoxyribonuclease activity | APEX1;APEX2 |
| endodeoxyribonuclease activity | ERCC4;MRE11A;ERCC5;DNASE1L3L;RPS3;DNASE1L3;MBD4;APLF;DNASE2A |
| endonuclease activity | PPP1R8;RNASE3;RAG1;CL2;EAR14;PMS2;RNASE2;ENDOU2;RNASEKB |
| metal ion binding | RUFY2;RBM22;RNF144AA;KLF11A;PLD6;PFKM;ZNF558;RFWD2;ISL2B |
| oxidoreductase activity | ERO1L;CYP19A1A;CYP1A1;PYCR1A;DLDH;AKR1CL1;SC4MOL;BCO2L;DHRS7 |
| phosphodiesterase I activity | APEX1;FAN1;ENPP1;ENPP2 |
| phosphoric diester hydrolase activity | PLCXD1;GDPD3A;PLCXD2;PDE5AB;PLCD1A;PLCD1B;PLCXD3;GDPD4;ENPP6 |
| poly(A) RNA binding | TBL3;PPIE;CCDC137;YWHAG;MRPL42;XRCC5;HLTF;DIAP1;SLBP |
| protein binding | NTF3;FABP5;STX4;HPSE;MRAS;CD300LH;MED12;NANOS2;DOCK10 |
| site-specific endodeoxyribonuclease activity, specific for altered base | APEX1;DNA2 |
| transcription coactivator activity | CARM1;THRAP3;RNF14;CITED4;ZSCAN1;CTBP2;NR2C2;WNT3A;CITED1 |
| transcription corepressor activity | SKOR1;LHX1;ZEB1;ZFPM1;MNT;SSX2;MXD4;ANKRD1;THRB |
| uracil DNA N-glycosylase activity | UNGA;CCNO;TDG.1;APEX1;UNG;SMUG1;TDG |
APEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX1.
EP300; HSPA1A; SIRT1; mdm2_human_probe; SRPK2
- Q&As
- Reviews
Q&As (20)
Ask a questionThe recombinant APEX1 protein may have broader application prospects in future clinical applications, especially in the treatment of diseases related to DNA damage.
The recombinant APEX1 protein can be used in scientific research to study the DNA repair pathway and the pathogenesis of related diseases.
The APEX1 is a DNA repair enzyme that can repair DNA bases damaged by oxidation.
The recombinant APEX1 protein can perform biological functions in the body and participate in the repair process of DNA.
In general, there are no serious side effects from the use of APEX1 , but specific side effects need to be evaluated based on actual use.
Yes, the recombinant APEX1 protein has antioxidant effects and can help reduce the damage to cells caused by oxidative stress.
APEX1 is not currently widely used in gene therapy, but it may have potential applications in related studies.
Yes, some studies have shown that the APEX1 can improve the occurrence and development of cardiovascular disease.
The study and detection of APEX1 can be performed using conventional immunological and biochemical methods.
The synthesis methods of APEX1 mainly include prokaryotic expression system and eukaryotic expression system.
The antioxidant and DNA repair effects of APEX1 make it a potential candidate molecule for anticancer drugs.
Yes, some studies have shown that the presence of recombinant APEX1 protein can improve the efficiency of DNA repair.
The therapeutic effect of APEX1 can be evaluated through cell experiments, animal experiments and clinical trials.
Purified samples of APEX1 can be obtained by protein expression and purification techniques.
APEX1 can be used clinically to treat diseases related to DNA damage, such as cancer.
The APEX1 is relevant for the treatment of diseases related to DNA damage such as cancer and neurological diseases.
No studies have shown that recombinant APEX1 can extend life span.
When using APEX1 , it is necessary to pay attention to the appropriate dosage and method, and follow the relevant experimental procedures.
There are currently no commercially available APEX1 drugs, but research is ongoing.
Yes, the recombinant APEX1 protein is associated with cancer because its abnormal function in DNA damage repair can lead to the development of cancer.
Customer Reviews (5)
Write a reviewHigh clearance of APELA allow the drug to act more quickly and reach the therapeutic goal quickly.
Zero pollution in the production process has a positive impact on the environment.
Easy to use, good results, great results.
The sensitivity of APELA in Western blot is very high, and clear bands can be obtained even at low concentrations, indicating that it has the characteristics of high sensitivity and low background noise.
It still maintains stable performance after a long time of use, showing excellent product quality.
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