Aph1c
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Official Full Name
anterior pharynx defective 1c homolog (C. elegans)
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | APH1C-1769M | Recombinant Mouse APH1C Protein | Mammalian Cell | His |
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| Mouse | APH1C-619M | Recombinant Mouse APH1C Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | APH1C-619M-B | Recombinant Mouse APH1C Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mus musculus (Mouse) | RFL21735MF | Recombinant Full Length Mouse Putative Gamma-Secretase Subunit Aph-1C(Aph1C) Protein, His-Tagged | E.coli expression system | His | Full Length (1-258) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Aph1c Related Signal Pathway
Aph1c involved in several pathways and played different roles in them. We selected most pathways Aph1c participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Aph1c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DLC;RBPJB;YY1;RBPJA;HDAC2;ADAM12;KAT2B;PSEN2;DLK1 |
| Alzheimers disease | RYR3;ITPR3;COX7A2;COX7A1;ATP5G3;UQCRFS1;UQCR11;APH1B;CALM2 |
Aph1c has several biochemical functions, for example, endopeptidase activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Aph1c itself. We selected most functions Aph1c had, and list some proteins which have the same functions with Aph1c. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSMA4;MMP1A;PSMB9;CPNE1;ACE2;F9;PSMA6;TPP1;KLK1B16 |
| peptidase activity | IHH;PRSS48;OVCH2;FURIN;PRSS59.1;CAPN5A;CTSB;C6AST1;C6AST3 |
Aph1c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Aph1c here. Most of them are supplied by our site. Hope this information will be useful for your research of Aph1c.
- Q&As
- Reviews
Q&As (18)
Ask a questionAPH1C could be used as a biomarker for early diagnosis of Alzheimer's disease.
APH1C is involved in the regulation of Notch signaling pathway in neurodegenerative diseases, thus affecting physiological functions of the nervous system.
APH1C is involved in Notch signaling pathway and can be used as a target for screening compound drugs.
APH1C is a transmembrane protein.
APH1C plays an important role in the regulation of tumor growth and metastasis, and therefore has the potential to treat cancer.
The expression of APH1C is related to gender, age, race and other factors.
APH1C is mainly located in the endoplasmic reticulum and Golgi apparatus.
APH1C is involved in the regulation of apoptosis.
APH1C is mainly associated with neurodegenerative diseases, tumors and other diseases, such as Alzheimer's disease, cancer, etc.
The gene for the APH1C has been associated with susceptibility to Alzheimer's disease, and the susceptibility mutations need to be further studied.
APH1C is involved in Notch signaling pathway.
The biological activity of APH1C can be evaluated by cell culture experiment and mouse model experiment.
Post-translational modifications of APH1C s can be detected by mass spectrometry and other methods.
The expression level of APH1C could be detected by Western blot, immunohistochemistry and other methods.
APH1C plays a key role in cell growth and differentiation.
PH1C can be used to design brain agonists as targets for anticancer drugs.
APH1C s interact with a variety of proteins, such as nicastrin, pen-2, etc.
APH1C is widely used in anticancer drug research and neurological disease drug research.
Customer Reviews (4)
Write a reviewLow carbon emissions and friendly to the environment.
The short half-life and high clearance characteristics of APH1C give it greater advantages in tissue penetration and better access to the lesion site.
Stability of APH1C is very good, and its performance remains unchanged after repeated use, which brings great convenience to our experiment.
Specificity in Western blot is very good, the binding ability to the target protein is strong, and the cross-reactivity is low, indicating that it has high specificity and low cross-reactivity.
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