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APOD

  • Official Full Name

    Apolipoprotein D

  • Overview

    This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism
  • Synonyms

    APOD protein; Apolipoprotein D; apolipoprotein D OTTHUMP00000208788; ApoD; Apo-D; OTTHUMP00000208787;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Guinea pig
  • Human
  • Mouse
  • Rabbit
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOD-192H Recombinant Human APOD Protein, His-tagged HEK293 His
Human APOD-707H Recombinant Human APOD protein, GST-tagged Wheat Germ GST
Human APOD-1321H Recombinant Human Apolipoprotein D, GST-tagged E.coli GST
Human APOD-3653H Recombinant Human APOD, His-tagged E.coli His
Human ApoD-8447H Active Recombinant Human ApoD E.coli N/A
Human APOD-2602H Recombinant Human Apolipoprotein D E.coli N/A
Human APOD-1977H Recombinant Human Apolipoprotein D, His-tagged E.coli His
Human APOD-8781HCL Recombinant Human APOD 293 Cell Lysate HEK293 N/A
Human APOD-0297H Recombinant Human APOD Protein (Gln21-Ser189), N-His-tagged E.coli N-His Gln21-Ser189
Human APOD-1129HF Recombinant Full Length Human APOD Protein, GST-tagged In Vitro Cell Free System GST 189 amino acids
Human APOD-3645H Recombinant Human APOD protein, His-tagged E.coli His 14-189 aa
Human APOD-363H-B Recombinant Human APOD Protein Pre-coupled Magnetic Beads HEK293
Human APOD-1603HFL Recombinant Full Length Human APOD Protein, C-Flag-tagged Mammalian cells Flag
Human APOD-0298H Recombinant Human APOD Protein (Glu21-Ser189), C-His-tagged Mammalian cells C-His Glu21-Ser189
Human APOD-363H Recombinant Human APOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Apod-2041M Recombinant Mouse Apod protein, His & GST-tagged E.coli His/GST Met1~Leu189
Mouse APOD-1791M Recombinant Mouse APOD Protein Mammalian Cell His
Mouse APOD-637M-B Recombinant Mouse APOD Protein Pre-coupled Magnetic Beads HEK293
Mouse Apod-819M Recombinant Mouse Apod Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse APOD-637M Recombinant Mouse APOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APOD-725R Recombinant Rat APOD Protein Mammalian Cell His
Rat Apod-2042R Recombinant Rat Apod protein, His-tagged E.coli His Gln21~Leu189 (Accession # P23593)
Rat Apod-3572R Recombinant Rat Apod, His-tagged E.Coli or Yeast His 189
Rat APOD-381R Recombinant Rat APOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APOD-381R-B Recombinant Rat APOD Protein Pre-coupled Magnetic Beads HEK293
Rabbit APOD-225R Recombinant Rabbit APOD Protein, His-tagged E.coli N-His Gln22-Phe189
Cynomolgus Monkey APOD-305C Recombinant Cynomolgus APOD Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey APOD-55C-B Recombinant Cynomolgus Monkey APOD Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey APOD-55C Recombinant Cynomolgus Monkey APOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Guinea pig LOC100735684-3573C Recombinant Cavia porcellus (Guinea pig) LOC100735684, His-tagged E.Coli or Yeast His 189
Chicken APOD-1884C Recombinant Chicken APOD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOD Related Articles

APOD involved in several pathways and played different roles in them. We selected most pathways APOD participated on our site, such as SLC-mediated transmembrane transport, Transmembrane transport of small molecules, Transport of fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SLC-mediated transmembrane transportSLC13A5A;RHCGL1;SLC22A7;SLC2A10;SLC34A2A;SLC17A1;SLC30A8;SLC43A2B;SLC14A1
Transmembrane transport of small moleculesTRPC4AP;WNK2;SLC35B2;SLC43A2;SLC29A2;SLC7A11;ANO4;TSC22D3;MIPA
Transport of fatty acidsLCN1;SLC27A4;APOD;LCN15;LCN9;LCN12
Transport of vitamins, nucleosides, and related moleculesSLC35B4;SLC5A6B;SLCO2A1;LCN15;APOD;SLCO2B1;SLC29A4;SLCO3A1;SLCO4A1

APOD has several biochemical functions, for example, cholesterol binding, lipid transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOD itself. We selected most functions APOD had, and list some proteins which have the same functions with APOD. You can find most of the proteins on our site.

Function Related Protein
cholesterol bindingPTCH1;OSBPL1A;OSBPL7;PROM2;ABCA1;OSBPL8;SYP;SCP2;NPC1
lipid transporter activityAPOD;APOF;APOA4;CETP;APOC4;APOL3;VTG7;APOBB.1;MTTP
protein bindingSIVA1;CST2;TLX2;RPL30;GCC1;FBXO9;EPHA10;KRT25;PDIA2

APOD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOD here. Most of them are supplied by our site. Hope this information will be useful for your research of APOD.

a8ka83_human; STK24; CREB3; GRINL1A; A2M; ESR1; CDK19

Pourkargar, DB; Armaou, A; et al. APOD-Based Control of Linear Distributed Parameter Systems Under Sensor/Controller Communication Bandwidth Limitations. AICHE JOURNAL 61:434-447(2015).
Olah, Z; Kalman, J; et al. Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. JOURNAL OF ALZHEIMERS DISEASE 44:1303-1312(2015).
  • Q&As
  • Reviews

Q&As (19)

Ask a question
Are there any known interactions or associations between ApoD protein and other proteins or molecules in the body? 04/05/2023

Yes, ApoD protein has been found to interact with several other proteins and molecules. For example, it has been shown to interact with lipoprotein receptors involved in lipid metabolism, such as LDL receptor-related protein 1 (LRP1). Additionally, ApoD can bind to β-amyloid peptides, which are implicated in Alzheimer's disease. These interactions suggest potential roles for ApoD in modulating lipid transport and neurodegenerative processes.

Are there any genetic disorders associated with mutations in the ApoD gene? 06/29/2021

Mutations in the ApoD gene are not typically associated with any specific genetic disorders. However, variations in the ApoD gene have been linked to certain diseases or conditions, such as Alzheimer's disease, schizophrenia, and Parkinson's disease. The exact mechanisms and significance of these associations are still being investigated.

Can lifestyle factors or medications affect ApoD protein levels? 12/11/2020

Some studies suggest that lifestyle factors and medications may influence ApoD protein levels. For example, certain drugs, such as statins, have been found to increase ApoD protein expression. Additionally, lifestyle factors like exercise and dietary interventions may also impact ApoD levels. However, further research is needed to fully understand the relationship between these factors and ApoD protein.

What are the physiological functions of ApoD protein? 09/30/2020

ApoD protein has diverse physiological functions. It is primarily associated with lipid metabolism and transport, as it binds to lipids and lipophilic molecules, such as fatty acids and cholesterol. ApoD is also involved in stress response mechanisms, including protection against oxidative stress and neuronal damage. It has been implicated in modulating inflammation and immunity as well. Furthermore, ApoD may play a role in promoting neurite outgrowth and neuronal survival.

Is ApoD protein expressed in specific tissues or organs? 09/10/2020

ApoD protein is widely expressed in various tissues and organs throughout the body. It is highly abundant in the central nervous system, including the brain, where it is mainly localized in astrocytes. ApoD expression is also found in other tissues, such as the liver, kidney, adipose tissue, and reproductive organs. Its expression can be regulated by various factors, including hormones, stress, and aging.

Can ApoD protein contribute to neurodegenerative diseases? 07/09/2020

Research suggests that ApoD protein may play a role in neurodegenerative diseases. It has been found to interact with β-amyloid peptides, which form plaques in the brains of individuals with Alzheimer's disease. ApoD can bind to and stabilize β-amyloid, potentially influencing its aggregation and clearance. Additionally, ApoD may have neuroprotective effects by reducing oxidative stress and inflammation. However, the exact contributions of ApoD to neurodegenerative diseases are still being investigated.

What research techniques are used to study the functions and mechanisms of ApoD protein? 12/27/2019

Various techniques are employed to study the functions and mechanisms of ApoD protein. These include in vitro experiments using cell cultures to investigate its interactions, expression, and functions. Animal models, such as knockout or transgenic mice with modified ApoD genes, are also used to study the effects of ApoD protein on specific processes or diseases. Additionally, sophisticated imaging techniques and proteomic analyses can provide insights into the localization and interactions of ApoD within tissues and organs.

Are there any therapeutic implications or potential treatments targeting ApoD protein? 11/20/2019

The potential therapeutic implications of ApoD protein are still being explored. Some studies have suggested that increasing ApoD levels could have neuroprotective effects and may be beneficial in neurodegenerative diseases. Additionally, modulating ApoD expression or function could potentially impact lipid metabolism and associated disorders. However, it is important to note that any potential treatment strategies targeting ApoD are still in the early stages of development and further research is needed.

Is there a link between APOD protein and sleep regulation? 10/14/2019

Yes, studies have shown that APOD levels fluctuate with the sleep-wake cycle, with higher expression during periods of sleep. APOD knockout mice exhibit altered sleep patterns, suggesting a role in the regulation of sleep duration and quality.

Are there any diseases associated with APOD protein? 06/03/2019

APOD has been implicated in various diseases, including cancer, neurodegenerative disorders, obesity, and metabolic disorders. However, further research is needed to fully understand its involvement in these conditions.

Can APOD protein be a therapeutic target for any diseases? 08/02/2018

The potential of APOD protein as a therapeutic target is still being investigated. Its involvement in various diseases suggests that modulating its expression or activity could have therapeutic benefits. However, more research is needed to fully understand its mechanisms and determine its suitability as a target.

How does APOD protein contribute to neuroprotection? 02/26/2018

APOD has been shown to have neuroprotective properties. It may protect against oxidative stress and inflammation, and contribute to the maintenance and survival of neurons. It has been implicated in neurodegenerative disorders like Alzheimer's disease.

Where is ApoD protein found in the body? 10/30/2017

ApoD protein is found in various tissues throughout the body, including the brain, liver, kidneys, and adipose tissue. It is also present in the cerebrospinal fluid and can be detected in plasma.

How is APOD protein involved in lipid metabolism? 10/14/2017

APOD is thought to play a role in the regulation of lipid metabolism and transport. It has been found to interact with lipids and lipoproteins and may contribute to the metabolism and transport of fatty acids and cholesterol.

Can ApoD protein be used as a diagnostic marker for certain diseases? 08/02/2017

ApoD protein has shown potential as a diagnostic marker for certain diseases. For example, its altered levels have been observed in neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. Additionally, changes in ApoD levels have been associated with certain types of cancer, such as breast cancer. However, more research is necessary to establish the reliability and specificity of ApoD as a diagnostic marker.

Are there any ongoing research studies or clinical trials related to ApoD protein? 11/06/2016

Research studies and clinical trials related to ApoD protein are ongoing to further understand its functions and potential implications in various diseases. Some areas of research include investigating its role in neurodegenerative disorders, exploring its potential as a diagnostic marker, and studying its therapeutic potential. Clinical trials may also be exploring interventions targeting ApoD, although specific trials may vary depending on current advancements in the field.

How is ApoD protein measured in laboratory tests or clinical settings? 09/16/2016

ApoD protein levels can be measured in laboratory tests or clinical settings using various techniques. One common method is enzyme-linked immunosorbent assay (ELISA), where antibodies specific to ApoD are used to detect and quantify its concentration in biological samples, such as blood or cerebrospinal fluid.

Is ApoD protein involved in aging-related processes? 06/01/2016

There is evidence suggesting a potential involvement of ApoD protein in aging-related processes. Studies have shown that ApoD levels increase with age in various tissues, including the brain. Additionally, ApoD has been implicated in stress response mechanisms and protecting against oxidative damage, which are both important factors in aging. However, further research is needed to fully understand the specific contributions of ApoD to the aging process.

Does the expression of ApoD protein change with aging? 05/29/2016

Yes, there is evidence that the expression of ApoD protein changes with aging. Studies have shown that ApoD levels increase with age in various tissues, including the brain. This upregulation of ApoD expression may be a protective response to counteract age-related oxidative stress and inflammation. The increased expression of ApoD in older individuals suggests it may have a role in the aging process, but further research is needed to fully understand its implications.

Customer Reviews (4)

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Reviews
05/31/2022

    Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

    04/15/2022

      Their comprehensive certificates of analysis and safety data sheets serve as testaments to their commitment to ensuring the safety and integrity of their products.

      05/05/2020

        In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

        01/31/2016

          Their ability to accommodate the requirements of large-scale experiments and guarantee a steady supply streamlines my research operations, eliminating any concerns related to prospective shortages.

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