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Aqp2

  • Official Full Name

    aquaporin 2 (collecting duct)

  • Overview

    Aquaporin 2 (AQP2) is a water transport protein that forms water channels in kidney tubules and plays a predominant role in controlling organism water homeostasis. Members of the aquaporin family are multiple pass transmembrane proteins that form homotetr
  • Synonyms

    AQP2; aquaporin 2 (collecting duct); aquaporin-2; AQP-2; aquaporin-CD; ADH water channel; water-channel aquaporin 2; collecting duct water channel protein; water channel protein for renal collecting duct; AQP-CD; WCH-CD; MGC34501;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Amblysomus hottentotus (Hottentot golden mole)
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Dasypus novemcinctus (Nine-banded armadillo)
  • Dugong dugon (Dugong) (Trichechus dugon)
  • Elephas maximus (Indian elephant)
  • Equus caballus (Horse)
  • Erinaceus europaeus (Western European hedgehog)
  • Homo sapiens (Human)
  • Human
  • Macroscelides proboscideus (Short-eared elephant shrew)
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Orycteropus afer (Aardvark)
  • Oryctolagus cuniculus (Rabbit)
  • Ovis aries (Sheep)
  • Procavia capensis habessinica (Abyssinian hyrax)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Talpa europaea (European mole)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP2-733H Recombinant Human AQP2 protein, GST-tagged Wheat Germ GST
Human AQP2-3593H Recombinant Human AQP2, His-tagged, GST-tagged E.coli His/GST 271
Human AQP2-1156HF Recombinant Full Length Human AQP2 Protein, GST-tagged In Vitro Cell Free System GST 271 amino acids
Human AQP2-0591H Recombinant Human AQP2 Protein (His177-Ala271), N-GST-tagged E.coli N-GST His177-Ala271
Mouse Aqp2-3597M Recombinant Mouse Aqp2, His-tagged E.Coli or Yeast His 271
Mouse AQP2-1821M Recombinant Mouse AQP2 Protein Mammalian Cell His
Mouse Aqp2-1953M Recombinant Mouse Aqp2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-271aa
Mouse AQP2-648M-B Recombinant Mouse AQP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse AQP2-648M Recombinant Mouse AQP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AQP2-737R Recombinant Rat AQP2 Protein Mammalian Cell His
Rat Aqp2-1034R Recombinant Rat Aqp2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-271aa
Rat AQP2-393R Recombinant Rat AQP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AQP2-393R-B Recombinant Rat AQP2 Protein Pre-coupled Magnetic Beads HEK293
Amblysomus hottentotus (Hottentot golden mole) RFL-2502AF Recombinant Full Length Amblysomus Hottentotus Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Bos taurus (Bovine) RFL-7536BF Recombinant Full Length Bovine Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Canis lupus familiaris (Dog) (Canis familiaris) RFL-8058CF Recombinant Full Length Dog Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Dasypus novemcinctus (Nine-banded armadillo) RFL-21776DF Recombinant Full Length Dasypus Novemcinctus Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Dugong dugon (Dugong) (Trichechus dugon) RFL-34090DF Recombinant Full Length Dugong Dugon Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Elephas maximus (Indian elephant) RFL-25798EF Recombinant Full Length Elephas Maximus Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Equus caballus (Horse) RFL-17681EF Recombinant Full Length Horse Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Erinaceus europaeus (Western European hedgehog) RFL-17138EF Recombinant Full Length Erinaceus Europaeus Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Homo sapiens (Human) RFL-15495HF Recombinant Full Length Human Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Macroscelides proboscideus (Short-eared elephant shrew) RFL-13721MF Recombinant Full Length Macroscelides Proboscideus Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-111)
Milnesium tardigradum (Water bear) (Tardigrade) RFL4584MF Recombinant Full Length Milnesium Tardigradum Aquaporin-2(Aqp2) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-323)
Mus musculus (Mouse) RFL-31784MF Recombinant Full Length Mouse Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Orycteropus afer (Aardvark) RFL-2233OF Recombinant Full Length Orycteropus Afer Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Oryctolagus cuniculus (Rabbit) RFL-16287OF Recombinant Full Length Rabbit Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Ovis aries (Sheep) RFL-28356OF Recombinant Full Length Sheep Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Procavia capensis habessinica (Abyssinian hyrax) RFL-18498PF Recombinant Full Length Procavia Capensis Habessinica Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Rattus norvegicus (Rat) RFL-16839RF Recombinant Full Length Rat Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Rhesus Macaque AQP2-372R Recombinant Rhesus monkey AQP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AQP2-201R-B Recombinant Rhesus Macaque AQP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AQP2-201R Recombinant Rhesus Macaque AQP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Talpa europaea (European mole) RFL-6948TF Recombinant Full Length Talpa Europaea Aquaporin-2(Aqp2) Protein, His-Tagged E.coli expression system His Full Length (1-109)
Chicken AQP2-5516C Recombinant Chicken AQP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Aqp2 Related Articles

Aqp2 involved in several pathways and played different roles in them. We selected most pathways Aqp2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Aqp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Aqp2 has several biochemical functions, for example, glycerol channel activity, glycerol transmembrane transporter activity, water channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Aqp2 itself. We selected most functions Aqp2 had, and list some proteins which have the same functions with Aqp2. You can find most of the proteins on our site.

Function Related Protein
glycerol channel activityAQP8A.1;AQP1A.1;AQP8B;AQP8;AQP5;AQP2;MIP;AQP10A;AQP3B
glycerol transmembrane transporter activityAQP3B;AQP3A;AQP9A;AQP10B;AQP2;AQP1;AQP10A;AQP9B
water channel activityMIP;AQP4;AQP6;AQP1;AQP9;AQP10A;AQP8A.1;AQP3A;AQP8
water transmembrane transporter activityAQP4;AQP2;AQP10B;MIPA;AQP10A;AQP9A;AQP9;AQP9B;AQP8B

Aqp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Aqp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Aqp2.

Marlar, S; Arnspang, EC; et al. Elevated cAMP increases aquaporin-3 plasma membrane diffusion. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C598-C606(2014).
Arrighi, S; Aralla, M; et al. Immunolocalization of Aquaporin Water Channels in the Domestic Cat Male Genital Tract. REPRODUCTION IN DOMESTIC ANIMALS 49:17-26(2014).
  • Q&As
  • Reviews

Q&As (26)

Ask a question
Can AQP2-related disorders be inherited? 04/16/2023

Yes, AQP2-related disorders can be inherited. Some forms of nephrogenic diabetes insipidus (NDI) are caused by genetic mutations in the AQP2 gene, which can be inherited from one or both parents. These genetic mutations result in impaired or absent functional AQP2 channels, leading to the development of NDI.

Can AQP2-related disorders be inherited? 04/16/2023

Yes, AQP2-related disorders can be inherited. Some forms of nephrogenic diabetes insipidus (NDI) are caused by genetic mutations in the AQP2 gene, which can be inherited from one or both parents. These genetic mutations result in impaired or absent functional AQP2 channels, leading to the development of NDI.

Can AQP2-related disorders affect individuals of any age? 03/25/2023

Yes, AQP2-related disorders can affect individuals of any age. Some forms of AQP2 dysfunction, like congenital nephrogenic diabetes insipidus (NDI), may be present from birth and can affect infants and young children. On the other hand, acquired forms of NDI can develop later in life due to factors such as medication side effects, genetic mutations, kidney damage, or other medical conditions. It is important to consider the potential presence of AQP2-related disorders in individuals of all ages who present with symptoms such as excessive thirst, frequent urination, and electrolyte imbalances.

Can AQP2-related disorders affect individuals of any age? 03/25/2023

Yes, AQP2-related disorders can affect individuals of any age. Some forms of AQP2 dysfunction, like congenital nephrogenic diabetes insipidus (NDI), may be present from birth and can affect infants and young children. On the other hand, acquired forms of NDI can develop later in life due to factors such as medication side effects, genetic mutations, kidney damage, or other medical conditions. It is important to consider the potential presence of AQP2-related disorders in individuals of all ages who present with symptoms such as excessive thirst, frequent urination, and electrolyte imbalances.

Is there any known post-translational modification of AQP2? 11/13/2022

Yes, AQP2 undergoes several post-translational modifications, including phosphorylation and ubiquitination. Phosphorylation plays a critical role in the intracellular trafficking and translocation of AQP2 to the cell membrane, while ubiquitination is involved in the degradation of AQP2.

Can lifestyle modifications be helpful in managing AQP2-related disorders? 02/14/2022

Yes, lifestyle modifications can be helpful in managing AQP2-related disorders, especially in conditions like nephrogenic diabetes insipidus (NDI). These modifications may include ensuring adequate fluid intake to prevent dehydration, dietary adjustments to maintain electrolyte balance, and avoiding excessive alcohol and caffeine consumption, which can increase urine production. It is always important to consult with a healthcare professional for personalized recommendations based on the specific condition and individual needs.

Can lifestyle modifications be helpful in managing AQP2-related disorders? 02/14/2022

Yes, lifestyle modifications can be helpful in managing AQP2-related disorders, especially in conditions like nephrogenic diabetes insipidus (NDI). These modifications may include ensuring adequate fluid intake to prevent dehydration, dietary adjustments to maintain electrolyte balance, and avoiding excessive alcohol and caffeine consumption, which can increase urine production. It is always important to consult with a healthcare professional for personalized recommendations based on the specific condition and individual needs.

What specific electrolyte imbalances can occur due to AQP2 dysfunction? 09/21/2021

AQP2 dysfunction can result in an imbalance of electrolytes such as sodium and potassium. In conditions like nephrogenic diabetes insipidus (NDI), where AQP2 is impaired, there is impaired water reabsorption and excessive urinary output. This can lead to dehydration and subsequent electrolyte imbalances, including hyponatremia (low sodium levels) and hyperkalemia (high potassium levels).

What specific electrolyte imbalances can occur due to AQP2 dysfunction? 09/21/2021

AQP2 dysfunction can result in an imbalance of electrolytes such as sodium and potassium. In conditions like nephrogenic diabetes insipidus (NDI), where AQP2 is impaired, there is impaired water reabsorption and excessive urinary output. This can lead to dehydration and subsequent electrolyte imbalances, including hyponatremia (low sodium levels) and hyperkalemia (high potassium levels).

What are the potential complications or long-term effects of AQP2-related disorders? 07/22/2021

The potential complications and long-term effects of AQP2-related disorders can vary depending on the specific condition and its severity. In conditions like nephrogenic diabetes insipidus (NDI), if left untreated or poorly managed, there is an increased risk of dehydration, electrolyte imbalances, and kidney damage. These complications can lead to symptoms such as fatigue, muscle weakness, dizziness, and in severe cases, kidney failure. It is important for individuals with AQP2-related disorders to receive proper medical care and ongoing management to prevent and address these potential complications.

What are the potential complications or long-term effects of AQP2-related disorders? 07/22/2021

The potential complications and long-term effects of AQP2-related disorders can vary depending on the specific condition and its severity. In conditions like nephrogenic diabetes insipidus (NDI), if left untreated or poorly managed, there is an increased risk of dehydration, electrolyte imbalances, and kidney damage. These complications can lead to symptoms such as fatigue, muscle weakness, dizziness, and in severe cases, kidney failure. It is important for individuals with AQP2-related disorders to receive proper medical care and ongoing management to prevent and address these potential complications.

How is AQP2 involved in the urine concentrating mechanism? 05/16/2021

AQP2 plays a vital role in the urine concentrating mechanism in the kidneys. When vasopressin is released, AQP2 translocates from intracellular vesicles to the apical membrane of collecting duct cells. This process increases the permeability of water, allowing it to be reabsorbed from the urine back into the bloodstream, concentrating the urine.

How is AQP2 involved in the urine concentrating mechanism? 05/16/2021

AQP2 plays a vital role in the urine concentrating mechanism in the kidneys. When vasopressin is released, AQP2 translocates from intracellular vesicles to the apical membrane of collecting duct cells. This process increases the permeability of water, allowing it to be reabsorbed from the urine back into the bloodstream, concentrating the urine.

What are some disorders or diseases associated with AQP2 dysfunction? 12/16/2020

Mutations or dysregulation of AQP2 can lead to several disorders related to water balance, including nephrogenic diabetes insipidus (NDI). This condition impairs the kidney's ability to concentrate urine, resulting in excessive thirst and urination.

Are there any ongoing research studies or advancements in understanding AQP2-related disorders? 05/25/2020

Yes, research on AQP2-related disorders is ongoing. Scientists are studying various aspects such as the molecular mechanisms behind AQP2 regulation, the development of targeted therapies for AQP2 dysfunction, and the identification of genetic mutations associated with these disorders. Furthermore, advancements in genetic testing techniques have allowed for better diagnosis and classification of AQP2-related disorders, leading to improved patient management and personalized treatment approaches.

Are there any ongoing research studies or advancements in understanding AQP2-related disorders? 05/25/2020

Yes, research on AQP2-related disorders is ongoing. Scientists are studying various aspects such as the molecular mechanisms behind AQP2 regulation, the development of targeted therapies for AQP2 dysfunction, and the identification of genetic mutations associated with these disorders. Furthermore, advancements in genetic testing techniques have allowed for better diagnosis and classification of AQP2-related disorders, leading to improved patient management and personalized treatment approaches.

Can genetic mutations in the AQP2 gene lead to water imbalance disorders? 11/12/2019

Yes, mutations in the AQP2 gene can cause hereditary nephrogenic diabetes insipidus (NDI), a condition characterized by the inability of the kidneys to concentrate urine. These mutations can affect AQP2 synthesis, trafficking, or function, leading to decreased water reabsorption and excessive urination.

Can AQP2-related disorders be cured? 06/04/2019

Currently, there is no known cure for AQP2-related disorders. However, effective management and treatment approaches can significantly improve the quality of life for individuals with these conditions. Depending on the specific disorder, treatments may include medication, dietary modifications, fluid management, and addressing any underlying causes or contributing factors. Ongoing research aims to develop more targeted therapies and interventions to better manage and potentially reverse AQP2 dysfunction, but as of now, the focus is on symptom management and preventing complications.

Can AQP2-related disorders be cured? 06/04/2019

Currently, there is no known cure for AQP2-related disorders. However, effective management and treatment approaches can significantly improve the quality of life for individuals with these conditions. Depending on the specific disorder, treatments may include medication, dietary modifications, fluid management, and addressing any underlying causes or contributing factors. Ongoing research aims to develop more targeted therapies and interventions to better manage and potentially reverse AQP2 dysfunction, but as of now, the focus is on symptom management and preventing complications.

Are there any physiological conditions that can affect AQP2 expression? 05/04/2019

Several physiological conditions can affect AQP2 expression. For example, dehydration stimulates the release of vasopressin, leading to increased AQP2 expression and water reabsorption. On the other hand, excessive water intake or the use of certain medications, such as diuretics, can suppress AQP2 expression, resulting in increased urine output.

Can AQP2 be targeted for therapeutic purposes? 11/18/2017

Targeting AQP2 could potentially be useful in the treatment of certain water balance disorders. For instance, pharmacological agents that enhance AQP2 expression or function may be beneficial in patients with nephrogenic diabetes insipidus. However, further research is needed to develop specific and safe therapeutic strategies.

How does AQP2 differ from other aquaporin proteins? 07/25/2017

AQP2 is a specific member of the aquaporin family, characterized by its expression primarily in the kidney and involvement in water reabsorption. It differs from other aquaporin proteins in terms of its tissue distribution, regulation, and function.

Are there any treatments or therapies available for AQP2-related disorders? 03/14/2017

The treatment options for AQP2-related disorders depend on the specific condition. In nephrogenic diabetes insipidus (NDI), medication options may include thiazide diuretics, which reduce urine production, or nonsteroidal anti-inflammatory drugs (NSAIDs) that can increase the responsiveness of the kidneys to vasopressin. In some cases, dietary adjustments and fluid management are also prescribed. However, the specific treatment plan will be determined by a healthcare professional and tailored to the individual patient's needs.

Are there any treatments or therapies available for AQP2-related disorders? 03/14/2017

The treatment options for AQP2-related disorders depend on the specific condition. In nephrogenic diabetes insipidus (NDI), medication options may include thiazide diuretics, which reduce urine production, or nonsteroidal anti-inflammatory drugs (NSAIDs) that can increase the responsiveness of the kidneys to vasopressin. In some cases, dietary adjustments and fluid management are also prescribed. However, the specific treatment plan will be determined by a healthcare professional and tailored to the individual patient's needs.

Are there any natural or synthetic compounds that modulate AQP2 expression or function? 02/23/2017

Certain compounds, such as synthetic vasopressin analogs (vasopressin agonists) or vasopressin receptor antagonists, can modulate AQP2 expression or function indirectly by affecting the release or binding of vasopressin. These medications are used in the treatment of water balance disorders or conditions where AQP2 dysregulation is involved.

How is AQP2 regulated during vasopressin release? 05/11/2016

Vasopressin release is triggered by changes in blood osmolality or volume. When the osmolality increases or blood volume decreases, osmoreceptors or baroreceptors in the body signal the release of vasopressin. Vasopressin then binds to its receptor in the kidney, activating the intracellular cAMP signaling pathway. This pathway leads to phosphorylation of AQP2 and its subsequent translocation to the cell membrane, increasing water reabsorption.

Customer Reviews (5)

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Reviews
04/15/2023

    This can be particularly important in clinical trials to ensure accurate and reliable results.

    11/05/2021

      Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the AQP2 protein.

      04/21/2021

        Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.

        02/02/2017

          They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.

          01/23/2016

            Manufacturers can provide researchers with purified and validated AQP2 protein, ensuring its quality and reliability for use in experiments and trials.

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