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AQP7

  • Official Full Name

    aquaporin 7

  • Overview

    may play a role in fluid transport and homeostasis during testis development and spermatogenesis
  • Synonyms

    AQP7; aquaporin 7; aquaporin-7; AQP 7; AQP 7L; AQP 9; AQP-7; AQP7_HUMAN; AQP7L; AQP9; AQPap; Aquaglyceroporin-7; Aquaporin 7 like; Aquaporin adipose; Aquaporin-7-like; Aquaporin7; MGC149555; MGC149556;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP7-735H Recombinant Human AQP7 protein, GST-tagged Wheat Germ GST
Human AQP7-3604H Recombinant Human AQP7, His-tagged E.Coli or Yeast His 342
Human AQP7-104HCL Recombinant Human AQP7 cell lysate N/A
Human AQP7-1158HF Recombinant Full Length Human AQP7 Protein, GST-tagged In Vitro Cell Free System GST 342 amino acids
Human AQP7-2586H Recombinant Human AQP7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AQP7-238H Recombinant Human AQP7 Protein, His-tagged E.coli N-His Gly218-Phe342
Human AQP7-0407H Recombinant Human AQP7 Protein (Leu68-Gly122), N-GST-tagged E.coli N-GST Leu68-Gly122
Mouse AQP7-1826M Recombinant Mouse AQP7 Protein Mammalian Cell His
Mouse AQP7-652M Recombinant Mouse AQP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Aqp7-821M Recombinant Mouse Aqp7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AQP7-652M-B Recombinant Mouse AQP7 Protein Pre-coupled Magnetic Beads HEK293
Rat Aqp7-3603R Recombinant Rat Aqp7, His-tagged E.Coli or Yeast His 269
Rat AQP7-741R Recombinant Rat AQP7 Protein Mammalian Cell His
Rat AQP7-397R-B Recombinant Rat AQP7 Protein Pre-coupled Magnetic Beads HEK293
Rat AQP7-397R Recombinant Rat AQP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey AQP7-307C Recombinant Cynomolgus AQP7 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey AQP7-57C-B Recombinant Cynomolgus Monkey AQP7 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey AQP7-57C Recombinant Cynomolgus Monkey AQP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL-34045HF Recombinant Full Length Human Aquaporin-7(Aqp7) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL21740MF Recombinant Full Length Macaca Fascicularis Aquaporin-7(Aqp7) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Milnesium tardigradum (Water bear) (Tardigrade) RFL21790MF Recombinant Full Length Milnesium Tardigradum Aquaporin-7(Aqp7) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-315)
Mus musculus (Mouse) RFL-19170MF Recombinant Full Length Mouse Aquaporin-7(Aqp7) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Rattus norvegicus (Rat) RFL-20874RF Recombinant Full Length Rat Aquaporin-7(Aqp7) Protein, His-Tagged E.coli expression system His Full Length (1-269)
Zebrafish AQP7-10279Z Recombinant Zebrafish AQP7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQP7 Related Articles

AQP7 involved in several pathways and played different roles in them. We selected most pathways AQP7 participated on our site, such as PPAR signaling pathway, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayACOX1;PCK1;CPT1C;ACSL4B;MMP1;ACSL1A;ACAA1;GK;ADIPOQ
Regulation of lipolysis in adipocytesPIK3R3;PIK3R1;PDE3B;PIK3R5;GNAI3;TSHR;PIK3CG;PTGS2;AKT2

AQP7 has several biochemical functions, for example, glycerol channel activity, urea transmembrane transporter activity, water channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP7 itself. We selected most functions AQP7 had, and list some proteins which have the same functions with AQP7. You can find most of the proteins on our site.

Function Related Protein
glycerol channel activityAQP1A.2;AQP10;AQP9;AQP3B;MIP;AQP9B;AQP1;AQP6;AQP8A.2
urea transmembrane transporter activityAQP9B;AQP10A;AQP10B;AQP3A;AQP7;AQP8A.1;AQP8A.2;AQP10;AQP3B
water channel activityAQP1A.1;AQP7;AQP8A.2;AQP4;AQP2;AQP8;AQP10A;AQP10;AQP1

AQP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP7.

Madsen, SS; Bujak, J; et al. Aquaporin expression in the Japanese medaka (Oryzias latipes) in freshwater and seawater: challenging the paradigm of intestinal water transport?. JOURNAL OF EXPERIMENTAL BIOLOGY 217:3108-3121(2014).
Tran, TL; Bek, T; et al. Altered aquaporin expression in glaucoma eyes. APMIS 122:772-780(2014).
  • Q&As
  • Reviews

Q&As (26)

Ask a question
Is AQP7 predominantly expressed in adipose tissue, or is it found in other tissues as well? 06/15/2022

While AQP7 is most prominently expressed in adipose tissue, it is also present in other tissues throughout the body. It has been detected in tissues such as the pancreas, liver, kidney, skeletal muscle, and reproductive organs. In these tissues, AQP7 may have various physiological functions related to water and glycerol transport. Its expression levels, however, can vary between different tissues and organs.

Is AQP7 predominantly expressed in adipose tissue, or is it found in other tissues as well? 06/15/2022

While AQP7 is most prominently expressed in adipose tissue, it is also present in other tissues throughout the body. It has been detected in tissues such as the pancreas, liver, kidney, skeletal muscle, and reproductive organs. In these tissues, AQP7 may have various physiological functions related to water and glycerol transport. Its expression levels, however, can vary between different tissues and organs.

Can AQP7 play a role in maintaining water balance in the body? 12/26/2021

While AQP7 is primarily known for its role in glycerol transport, it can also facilitate water transport due to its properties as an aquaporin. However, the contribution of AQP7 to overall water regulation in the body may be relatively minor compared to other aquaporin isoforms, such as AQP1 in the kidney.

Are there any diseases or conditions associated with AQP7 dysfunction? 10/08/2021

Mutations or dysregulation of AQP7 have been implicated in metabolic disorders such as obesity and type 2 diabetes. In individuals with reduced AQP7 expression or function, there may be altered glycerol metabolism in adipose tissue, leading to abnormal lipid storage and potentially contributing to insulin resistance and metabolic imbalances.

Can AQP7 influence lipid metabolism in the body? 07/27/2021

Yes, AQP7 has been shown to play a role in lipid metabolism. It facilitates the movement of glycerol, a component of triglycerides, across cell membranes in adipose tissue. A deficiency in AQP7 has been associated with altered lipid metabolism and increased fat accumulation in certain studies.

Can AQP7 influence lipid metabolism in the body? 07/27/2021

Yes, AQP7 has been shown to play a role in lipid metabolism. It facilitates the movement of glycerol, a component of triglycerides, across cell membranes in adipose tissue. A deficiency in AQP7 has been associated with altered lipid metabolism and increased fat accumulation in certain studies.

Is there any current research investigating the therapeutic potential of AQP7 targeting? 06/14/2021

Yes, there is ongoing research aimed at exploring the therapeutic potential of targeting AQP7 in metabolic disorders. This includes studying the mechanisms underlying AQP7 regulation and function, as well as determining strategies to modulate its expression or activity. Additionally, researchers are investigating the effects of pharmacological agents or interventions that can indirectly affect AQP7 function to improve metabolic health.

Can AQP7 be used as a biomarker for any diseases? 04/08/2021

AQP7 has been investigated as a potential biomarker for certain diseases. For example, in obesity and metabolic disorders, altered AQP7 expression levels in adipose tissue have been associated with disease progression. Additionally, AQP7 expression changes have been observed in certain cancers, as mentioned earlier. However, the use of AQP7 as a biomarker is still in the exploratory stages, and more research is required to determine its diagnostic or prognostic value for specific diseases.

Can AQP7 be used as a biomarker for any diseases? 04/08/2021

AQP7 has been investigated as a potential biomarker for certain diseases. For example, in obesity and metabolic disorders, altered AQP7 expression levels in adipose tissue have been associated with disease progression. Additionally, AQP7 expression changes have been observed in certain cancers, as mentioned earlier. However, the use of AQP7 as a biomarker is still in the exploratory stages, and more research is required to determine its diagnostic or prognostic value for specific diseases.

Are there any known genetic variants or mutations in AQP7 associated with diseases? 03/27/2021

Yes, several genetic variants and mutations in the AQP7 gene have been identified in individuals with metabolic disorders. These include single-nucleotide polymorphisms (SNPs) that may be associated with an increased risk of obesity, insulin resistance, and type 2 diabetes. However, the precise functional consequences of these genetic variations and their role in disease development are still being elucidated.

Are there any known interactions or associations of AQP7 with other proteins? 08/30/2020

Yes, AQP7 has been found to interact with other proteins that participate in glycerol metabolism or adipocyte function. For example, it interacts with Perilipin-1, a protein involved in lipid droplet formation and regulation. This interaction suggests a potential role of AQP7 in lipid storage and adipocyte physiology. Moreover, AQP7 may interact with other aquaporin family members or transporters to modulate glycerol transport across membranes.

Is there any link between AQP7 and diabetes or insulin resistance? 07/21/2020

Yes, there have been studies examining the potential link between AQP7 and diabetes or insulin resistance. One study found that AQP7 expression in adipose tissue was decreased in individuals with type 2 diabetes compared to healthy controls. Another study suggested that AQP7 may play a role in the regulation of glucose metabolism, as mice lacking AQP7 exhibited impaired glucose tolerance and insulin resistance. These findings suggest that AQP7 may be involved in the development of diabetes and insulin resistance, but more research is needed to fully understand the mechanisms and potential therapeutic implications.

Is there any link between AQP7 and diabetes or insulin resistance? 07/21/2020

Yes, there have been studies examining the potential link between AQP7 and diabetes or insulin resistance. One study found that AQP7 expression in adipose tissue was decreased in individuals with type 2 diabetes compared to healthy controls. Another study suggested that AQP7 may play a role in the regulation of glucose metabolism, as mice lacking AQP7 exhibited impaired glucose tolerance and insulin resistance. These findings suggest that AQP7 may be involved in the development of diabetes and insulin resistance, but more research is needed to fully understand the mechanisms and potential therapeutic implications.

Are there any studies investigating the role of AQP7 in cancer? 06/24/2020

Yes, there are some studies that have explored the potential involvement of AQP7 in cancer development and progression. It has been suggested that AQP7 expression may be altered in certain cancers, including breast cancer, ovarian cancer, and gastric cancer. Some studies have shown that overexpression of AQP7 can promote tumor growth and metastasis, while others have indicated that AQP7 may have tumor-suppressive effects. The exact mechanisms by which AQP7 influences cancer biology are still being investigated and further research is needed in this area.

Are there any studies investigating the role of AQP7 in cancer? 06/24/2020

Yes, there are some studies that have explored the potential involvement of AQP7 in cancer development and progression. It has been suggested that AQP7 expression may be altered in certain cancers, including breast cancer, ovarian cancer, and gastric cancer. Some studies have shown that overexpression of AQP7 can promote tumor growth and metastasis, while others have indicated that AQP7 may have tumor-suppressive effects. The exact mechanisms by which AQP7 influences cancer biology are still being investigated and further research is needed in this area.

Can alterations in AQP7 expression or function impact fertility or reproductive health? 05/12/2020

AQP7 has been found to be expressed in reproductive organs such as the testes and ovaries, suggesting a potential role in fertility. However, the specific impact of AQP7 alterations on reproductive health or fertility is not yet fully understood and requires further investigation. It is possible that disruptions in AQP7-mediated glycerol transport could affect lipid metabolism in reproductive tissues, potentially influencing reproductive function.

Is there any potential for therapeutic targeting of AQP7 in metabolic disorders? 02/21/2019

The potential therapeutic targeting of AQP7 in metabolic disorders is an area of active research. Modulating AQP7 expression or function could potentially be explored as a strategy to improve metabolic health and treat conditions such as obesity and type 2 diabetes. However, more research is needed to understand the specific mechanisms and develop effective therapeutic interventions for targeting AQP7 in these disorders.

Can changes in AQP7 expression or function contribute to fluid imbalance disorders such as edema? 02/17/2019

It is possible that changes in AQP7 expression or function could contribute to fluid imbalance disorders such as edema, although the exact role of AQP7 in these conditions is not well-defined. Edema can result from a disturbance in fluid balance, and since AQP7 is involved in water transport, alterations in its expression or activity may potentially affect fluid homeostasis in certain tissues or organs. However, more research is needed to determine the specific contributions of AQP7 to the development and progression of fluid imbalance disorders.

Can changes in AQP7 expression or function contribute to fluid imbalance disorders such as edema? 02/17/2019

It is possible that changes in AQP7 expression or function could contribute to fluid imbalance disorders such as edema, although the exact role of AQP7 in these conditions is not well-defined. Edema can result from a disturbance in fluid balance, and since AQP7 is involved in water transport, alterations in its expression or activity may potentially affect fluid homeostasis in certain tissues or organs. However, more research is needed to determine the specific contributions of AQP7 to the development and progression of fluid imbalance disorders.

Has AQP7 been implicated in any neurological disorders or brain functions? 01/08/2019

While the primary function of AQP7 is associated with fluid and glycerol transport in adipose tissue, there is some evidence suggesting its involvement in neurological disorders and brain functions. For example, AQP7 has been detected in certain areas of the brain, and changes in its expression have been observed in conditions such as epilepsy and traumatic brain injury.

Has AQP7 been implicated in any neurological disorders or brain functions? 01/08/2019

While the primary function of AQP7 is associated with fluid and glycerol transport in adipose tissue, there is some evidence suggesting its involvement in neurological disorders and brain functions. For example, AQP7 has been detected in certain areas of the brain, and changes in its expression have been observed in conditions such as epilepsy and traumatic brain injury.

Can AQP7 be targeted for drug development? 09/18/2018

Although the therapeutic targeting of AQP7 is an intriguing possibility, developing drugs that specifically modulate AQP7 activity is a challenging task. Aquaporins have a highly conserved structure and function, and developing selective modulators for a specific aquaporin subtype like AQP7 has proven difficult. However, ongoing research may unveil potential avenues for drug development targeting AQP7 or related pathways involved in glycerol metabolism.

Are there any genetic variations or mutations in the AQP7 gene associated with diseases? 07/06/2018

Yes, there have been genetic variations and mutations identified in the AQP7 gene that are associated with diseases. For example, a specific mutation in the AQP7 gene has been linked to a rare genetic disorder called congenital generalized lipodystrophy (CGL), which is characterized by the loss of adipose tissue and metabolic abnormalities. Other genetic variations in the AQP7 gene have also been associated with different metabolic disorders, such as obesity and type 2 diabetes. These findings suggest that genetic variations in the AQP7 gene can contribute to the development of certain diseases, although more research is needed to understand the full extent of these associations.

Are there any genetic variations or mutations in the AQP7 gene associated with diseases? 07/06/2018

Yes, there have been genetic variations and mutations identified in the AQP7 gene that are associated with diseases. For example, a specific mutation in the AQP7 gene has been linked to a rare genetic disorder called congenital generalized lipodystrophy (CGL), which is characterized by the loss of adipose tissue and metabolic abnormalities. Other genetic variations in the AQP7 gene have also been associated with different metabolic disorders, such as obesity and type 2 diabetes. These findings suggest that genetic variations in the AQP7 gene can contribute to the development of certain diseases, although more research is needed to understand the full extent of these associations.

Are there any known drugs or compounds that can modulate AQP7 expression or activity? 03/30/2017

There have been studies that have identified certain drugs or compounds that can modulate AQP7 expression or activity. For example, compounds such as retinoic acid and thiazolidinediones (TZDs) have been shown to increase AQP7 expression in adipose tissue. On the other hand, substances like forskolin and adrenaline have been found to decrease AQP7 expression. These findings suggest potential therapeutic strategies for targeting AQP7 in metabolic disorders, but further research is needed to fully understand the effects and clinical implications of these compounds.

Are there any known drugs or compounds that can modulate AQP7 expression or activity? 03/30/2017

There have been studies that have identified certain drugs or compounds that can modulate AQP7 expression or activity. For example, compounds such as retinoic acid and thiazolidinediones (TZDs) have been shown to increase AQP7 expression in adipose tissue. On the other hand, substances like forskolin and adrenaline have been found to decrease AQP7 expression. These findings suggest potential therapeutic strategies for targeting AQP7 in metabolic disorders, but further research is needed to fully understand the effects and clinical implications of these compounds.

Customer Reviews (8)

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Reviews
03/04/2023

    the AQP7 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.

    04/14/2022

      The reliable performance of the AQP7 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

      02/20/2022

        researchers have found AQP7 protein to be highly suitable for protein electron microscopy structure analysis.

        09/05/2019

          AQP7 protein is highly recommended for research applications, particularly in ELISA assays and protein electron microscopy structure analysis.

          07/01/2019

            Researchers who have utilized AQP7 protein praise its exceptional performance and reliability in their experiments.

            02/21/2019

              AQP7 protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.

              12/06/2018

                it has demonstrated remarkable effectiveness in ELISA experiments, showcasing its reliability and accuracy in detecting and quantifying specific targets.

                11/19/2018

                  the AQP7 protein has proven to be an invaluable asset in protein electron microscopy structure analysis.

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