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ARAP3

  • Official Full Name

    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

  • Overview

    This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined.
  • Synonyms

    ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; centaurin, delta 3 , CENTD3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; DRAG1; FLJ21065; Ankyrin repeat and plekstrin homology domains containing protein 3; ARAP 3; ARF GAP; ARF-GAP RHO-GAP ankyrin repeat and plekstrin homology domains containing protein 3; Phosphoinositide binding protein; PtdIns 3 4 5 P3 binding protein; RHO GAP; cnt-d3; centaurin-delta-3; centaurin, delta 3; PtdIns(3,4,5)P3-binding protein; Arf and Rho GAP adapter protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; CENTD3;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARAP3-9792H Recombinant Human ARAP3, His-tagged E.coli His C-term-320a.a.
Human ARAP3-2584H Recombinant Human ARAP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Arap3-317M Recombinant Mouse Arap3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARAP3 involved in several pathways and played different roles in them. We selected most pathways ARAP3 participated on our site, such as Rap signaling pathway, cAMP signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayGNAI1;ITGB1;PDGFB;VEGFA;KRIT1;PDGFA;PFN2;MRAS;ARAP3
cAMP signaling pathwayGRIA3;GRIN3B;VAV2;HCAR2;GABBR1;RAC1;GRIA4;GHRL;PPP1CB
EndocytosisWASB;VPS4B;CLTCA;WASL;MHC1UXA2;ACAP1;FLT1;WASH1;AGAP2

ARAP3 has several biochemical functions, for example, GTPase activator activity, NOT GTPase activator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP3 itself. We selected most functions ARAP3 had, and list some proteins which have the same functions with ARAP3. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activitySTXBP5L;RABEP2;RAP1GDS1;ARHGEF1;TBCD;RGS2;RGS16;RGS21;SOS1
NOT GTPase activator activityARAP3;ELMOD3;DLC1
metal ion bindingCYP2A12;EYA3;MYLIPB;ZNF329;CYP17A2;MBLAC1;SMPD3;ZNF763;LHX8A
phosphatidylinositol-3,4,5-trisphosphate bindingINPPL1;ARAP3;NRGN;AKT1;ARHGAP9;ARAP2;OGT;KIF16B;FAM21C
phosphatidylinositol-3,4-bisphosphate bindingPLEKHA1;PLEK;TTPA;ZFYVE1;AKT1;KIF16B;D6WSU116E;GAB2;PHLDA3
protein bindingZNRF1;ARHGAP33;IQSEC3;KEL;MYH8;RGS1;UBL4B;ZHX3;RHOV

ARAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP3.

SH3KBP1; pi3p

  • Q&As
  • Reviews

Q&As (12)

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What are the known protein interactors of ARAP3? 02/20/2023

ARAP3 interacts with various proteins to perform its functions. Some of the known protein interactors of ARAP3 include Rho GTPases (such as RhoA, Rac1, and Cdc42), phosphoinositides (such as phosphatidylinositol 3,4,5-trisphosphate or PIP3), Src family kinases, protein kinases (such as protein kinase D or PKD), and scaffolding proteins (such as Eps8 and IRSp53). These interactions play a crucial role in ARAP3-mediated signaling and cellular processes.

Is ARAP3 associated with any diseases or conditions? 01/12/2023

ARAP3 has been associated with several diseases and conditions. Mutations or dysregulation of ARAP3 have been implicated in neurological disorders like autism spectrum disorders and intellectual disabilities. Additionally, ARAP3 has been implicated in cancer progression and metastasis. Further research is needed to fully understand the extent of ARAP3 involvement in various diseases and explore its potential as a therapeutic target.

Does ARAP3 have any involvement in the immune system? 09/03/2021

Yes, ARAP3 has been found to play a role in immune responses. It can impact various immune cell functions, including T cell activation and migration, B cell signaling, and neutrophil recruitment. ARAP3 regulates specific signaling pathways and cytoskeletal rearrangements that are essential for immune cell activation and mobilization in response to immune challenges.

Can ARAP3 protein be targeted for therapeutic interventions? 08/01/2021

ARAP3 holds potential as a therapeutic target, particularly in diseases where its dysregulation contributes to pathological processes. Developing molecules that can modulate ARAP3 activity or disrupt its interactions with specific protein partners could provide avenues for therapeutic interventions. However, more research is necessary to explore the efficacy and safety of such interventions.

Is ARAP3 protein conserved across different species? 10/03/2020

ARAP3 is evolutionarily conserved across various species, indicating its importance in cellular processes. Homologs of ARAP3 can be found in both vertebrates and invertebrates, suggesting a fundamental role in cellular function. However, there might be species-specific differences in the regulation or interaction partners of ARAP3.

Does ARAP3 play a role in neuronal development or function? 02/15/2020

Yes, ARAP3 has been implicated in neuronal development and function. It has been shown to regulate dendritic spine morphogenesis, synaptic plasticity, and neuronal migration. Defects in ARAP3 function may contribute to neurological disorders, such as autism spectrum disorders and intellectual disabilities.

Are there any ongoing studies or clinical trials related to ARAP3? 01/22/2020

Currently, I do not have specific information on ongoing studies or clinical trials focused on ARAP3. However, it is advisable to consult scientific databases, research publications, or clinical trial registries for the latest information on any ongoing investigations involving ARAP3.

Are there any known interacting proteins with ARAP3? 01/20/2019

Yes, ARAP3 interacts with several proteins to carry out its functions. For instance, it interacts with small GTPases, such as Arf and Rho, to control their activity and localize them to specific cellular compartments. ARAP3 also interacts with other signaling molecules and scaffolding proteins that mediate its effects on cellular processes.

Are there any diseases or conditions associated with ARAP3 protein? 07/25/2017

Research suggests that dysregulation of ARAP3 expression or function may be involved in several diseases. For example, ARAP3 has been implicated in cancer progression and metastasis, as it promotes cell migration and invasion. Additionally, ARAP3 has been linked to cardiovascular diseases, such as atherosclerosis, as it influences endothelial cell migration and angiogenesis.

Are there any known mutations in the ARAP3 gene? 06/18/2017

Yes, mutations in the ARAP3 gene have been identified in some individuals. These mutations can lead to alterations in the ARAP3 protein structure or function and may be associated with certain diseases or conditions. However, further research is needed to fully understand the implications of these mutations.

Are there any known inhibitors or activators of ARAP3? 04/30/2016

While specific inhibitors or activators of ARAP3 are currently limited, some molecules have been identified that can modulate ARAP3 activity indirectly. For example, various small molecules can inhibit ARAP3-mediated RhoA activation. Additionally, certain growth factors and signaling molecules can activate or regulate ARAP3 function. However, the development of specific targeted inhibitors or activators of ARAP3 is an area of ongoing research.

Can the expression of ARAP3 be regulated by external cues or stimuli? 02/06/2016

Yes, the expression of ARAP3 can be regulated by external cues or stimuli. For example, studies have shown that certain growth factors, hormones, or cellular stresses can influence ARAP3 expression levels in different cell types. The exact mechanisms underlying this regulation and its significance in various physiological or pathological contexts are areas of ongoing research.

Customer Reviews (8)

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Reviews
05/16/2022

    With the manufacturer's excellent technical support and its wide range of applications, the ARAP3 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.

    10/16/2021

      the ARAP3 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.

      08/26/2021

        The versatility of the ARAP3 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.

        08/26/2021

          One notable advantage of using the ARAP3 protein is the outstanding technical support provided by its manufacturer.

          10/31/2020

            Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

            06/29/2020

              Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.

              08/16/2019

                The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

                10/01/2016

                  By using the ARAP3 protein in my experiments, I am confident in obtaining accurate and dependable data.

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