Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ARF5

  • Official Full Name

    ADP-ribosylation factor 5

  • Overview

    This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization.
  • Synonyms

    ARF5; ADP-ribosylation factor 5; ADP ribosylation factor 5; ARF 5; ARF5_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARF5-9802H Recombinant Human ARF5, GST-tagged E.coli GST 1-180a.a.
Human ARF5-748H Recombinant Human ARF5 protein, GST-tagged Wheat Germ GST
Human ARF5-3583H Recombinant Human ARF5 protein(Met1-Arg180), His-tagged E. coli N-His Met1-Arg180
Human ARF5-198H Recombinant Human ARF5, His tagged E.coli Fc
Human ARF5-8757HCL Recombinant Human ARF5 293 Cell Lysate HEK293 N/A
Human ARF5-5150H Recombinant Human ARF5 protein, GST-tagged E.coli GST 2-180aa
Human ARF5-1183HF Recombinant Full Length Human ARF5 Protein, GST-tagged In Vitro Cell Free System GST 180 amino acids
Mouse ARF5-1841M Recombinant Mouse ARF5 Protein Mammalian Cell His
Mouse ARF5-661M Recombinant Mouse ARF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Arf5-637M Recombinant Mouse Arf5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ARF5-661M-B Recombinant Mouse ARF5 Protein Pre-coupled Magnetic Beads HEK293
Rat ARF5-751R Recombinant Rat ARF5 Protein Mammalian Cell His
Rat Arf5-3209R Recombinant Rat Arf5, His-tagged E.Coli or Yeast His 180
Rat ARF5-407R-B Recombinant Rat ARF5 Protein Pre-coupled Magnetic Beads HEK293
Rat ARF5-407R Recombinant Rat ARF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARF5-9907Z Recombinant Zebrafish ARF5 Mammalian Cell His
Chicken ARF5-6877C Recombinant Chicken ARF5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARF5 Related Signal Pathway

ARF5 involved in several pathways and played different roles in them. We selected most pathways ARF5 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisWIPF1;FAM125B;RHOAD;CSF1R;ARF1L;RAB11FIP4;LDLRAP1;TGFB1A;MVB12BA

ARF5 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF5 itself. We selected most functions ARF5 had, and list some proteins which have the same functions with ARF5. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB1B;RAB4B;TRIM23;ARL8;ERAL1;TUBA4A;EHD3;RAP2A;TUBA1C
GTPase activityTUBA1A;TBCC;EFTUD1;RAP1A;RAB1;RAB17;RAB40AL;GNAZ;RALAB
protein bindingGSPT2;NF2;AMY1B;MED4;PRR13;THG1L;ADAM33;NEK2;A1CF

ARF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF5.

VCAM1; SNW1

  • Q&As
  • Reviews

Q&As (32)

Ask a question
Can ARF5 protein interact with the actin cytoskeleton? 02/21/2023

Yes, ARF5 protein can interact with the actin cytoskeleton. It has been shown to associate with actin filaments and regulate their organization and dynamics during processes such as cell migration and neurite outgrowth.

Can ARF5 protein be involved in neuronal development and neurite outgrowth? 09/23/2022

Yes, ARF5 has been implicated in neuronal development and neurite outgrowth. It regulates membrane trafficking events required for the extension and branching of neuronal processes, contributing to proper neuronal morphology and connectivity during development.

How is ARF5 protein involved in endocytic pathway? 02/18/2022

ARF5 plays a crucial role in the formation and maturation of clathrin-coated vesicles during endocytosis. It regulates the recruitment and assembly of clathrin and adaptors to the plasma membrane, facilitating the internalization of cargo molecules.

Are there any known ARF5-related experimental models or animal models? 12/31/2021

Yes, researchers have used cell lines and genetically modified mice to study the function and regulation of ARF5. These models help in understanding the physiological significance of ARF5 in cellular processes and its potential implications in disease.

Can mutations in the ARF5 gene lead to any diseases? 11/13/2021

While specific disease associations with ARF5 mutations are not well-established, abnormalities in ARF5 expression or function have been implicated in certain human disorders, including cancer and neurodevelopmental disorders.

Can ARF5 protein interact with other members of the ADP-ribosylation factor (ARF) family? 08/01/2021

Yes, ARF5 can interact with other ARF family members, such as ARF1 and ARF6. These interactions contribute to the regulation of intracellular trafficking and signaling processes.

In which cellular processes does ARF5 protein participate? 03/05/2021

ARF5 is involved in various cellular processes, including endocytic pathway, vesicle trafficking, Golgi apparatus maintenance, and signaling events.

Is there any literature on the involvement of ARF5 protein in specific diseases? 12/12/2020

While ARF5 has been implicated in various diseases, including cancer and neurodevelopmental disorders, the specific mechanisms and associations are still being investigated. The existing literature provides a foundation for further exploration in this area.

Can ARF5 protein influence cell signaling events? 12/12/2020

Yes, ARF5 can affect cell signaling by regulating the trafficking and distribution of signaling receptors and molecules. It can modulate the localization and activity of certain receptors, leading to alterations in downstream signaling pathways.

Does ARF5 play a role in vesicle trafficking between different organelles? 05/30/2020

Yes, ARF5 participates in vesicle trafficking between various organelles, including the Golgi apparatus and endosomes. It helps in the formation and sorting of vesicles carrying cargo between these compartments.

How is ARF5 protein involved in the regulation of insulin secretion in pancreatic beta cells? 03/24/2020

ARF5 is involved in the regulation of insulin secretion in pancreatic beta cells. It helps in the maintenance and organization of insulin granules within beta cells. ARF5 activity is required for the proper trafficking and fusion of insulin granules with the plasma membrane, leading to the release of insulin.

Is ARF5 protein involved in any cellular processes other than membrane trafficking? 12/20/2019

Yes, ARF5 protein is involved in various cellular processes in addition to membrane trafficking. It has been implicated in cell migration, cell proliferation, cellular signaling, and cytoskeletal organization. ARF5 can modulate these processes through its regulation of vesicle trafficking and membrane dynamics.

Can ARF5 protein influence the recycling of membrane proteins from endosomes back to the plasma membrane? 03/09/2019

Yes, ARF5 plays a role in recycling membrane proteins from endosomes back to the plasma membrane. It regulates the formation of recycling vesicles and the sorting of cargo molecules in the recycling pathway, ensuring proper membrane protein localization and cell surface expression.

Are there any known ARF5-related diseases in which ARF5 mutations are implicated? 01/17/2019

There are currently no known diseases specifically linked to ARF5 mutations. However, alterations in ARF5 function or expression have been observed in cancer progression, neurodevelopmental disorders, and insulin secretion defects. Further research is needed to better understand the role of ARF5 in disease processes.

Is ARF5 protein localized primarily to the cytoplasm or specific organelles? 10/31/2018

ARF5 is primarily localized to the cytoplasm of cells. However, it can also associate with specific membranes and organelles, such as the Golgi apparatus and endosomes, where it plays a role in regulating vesicle trafficking.

Are there any known ARF5 inhibitors or activators? 06/17/2018

There are currently no specific inhibitors or activators of ARF5 protein available. However, the activity of ARF5 can be regulated indirectly through its upstream regulators, such as GEFs and GAPs. Small molecules that target these regulators could potentially modulate ARF5 activity.

What are the potential downstream effectors of ARF5 protein? 02/24/2018

ARF5 interacts with various effector proteins, including adaptor protein complexes (AP-1 and AP-3), COPI, and phospholipase D, to mediate its diverse cellular functions.

Can modulation of ARF5 expression or activity be a potential therapeutic target? 12/31/2017

Yes, understanding the role of ARF5 in disease processes may lead to the development of targeted therapies aimed at modulating its activity, thereby affecting specific cellular functions and pathways. However, further research is needed to establish its clinical relevance.

Are there any known upstream regulators of ARF5 protein activity? 10/15/2017

ARF5 activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which control the loading and hydrolysis of GTP on ARF5, respectively. These regulators modulate ARF5's activation state and its interaction with downstream effectors.

Can ARF5 be targeted for therapeutic intervention in cancer? 09/05/2017

The potential role of ARF5 in cancer is still being explored. It has been implicated in tumor progression and metastasis. Targeting ARF5 activity or its downstream effectors may hold promise for therapeutic strategies, but further research is needed to determine its clinical significance.

Does ARF5 protein have any role in immune cell function? 09/04/2017

ARF5 has been shown to play a role in immune cell function. It is involved in processes such as phagocytosis, cytokine secretion, and immune cell migration. ARF5 regulates vesicle trafficking events that are crucial for immune cell activation and response.

Can ARF5 protein be regulated by post-translational modifications? 07/02/2017

Yes, ARF5 can be regulated by post-translational modifications. It can undergo phosphorylation, acetylation, and ubiquitination, among other modifications. These modifications can affect ARF5's activity, localization, and interactions with other proteins.

Are there any known drugs or compounds that specifically target ARF5 protein? 05/05/2017

Currently, there are no known drugs or compounds specifically designed to target ARF5 protein. However, with ongoing research and understanding of its functions and implications in diseases, future therapeutic interventions may emerge.

Can ARF5 protein interact with other proteins involved in endocytosis or vesicle trafficking? 03/07/2017

Yes, ARF5 can interact with various proteins involved in endocytosis and vesicle trafficking. It interacts with clathrin, adaptors, and other coat proteins to facilitate the formation and maturation of clathrin-coated vesicles. ARF5 also interacts with effector proteins involved in membrane trafficking, such as GEFs and GAPs.

Can ARF5 protein be regulated by cellular signaling pathways? 03/03/2017

Yes, ARF5 protein can be regulated by cellular signaling pathways. Activation of various signaling pathways, such as G protein-coupled receptor (GPCR) signaling or growth factor signaling, can affect ARF5 activity through the modulation of its GEFs and GAPs.

Can ARF5 protein influence membrane trafficking of neurotransmitters in neurons? 02/17/2017

Yes, ARF5 has been shown to play a role in membrane trafficking of neurotransmitters in neurons. It is involved in the regulation of synaptic vesicle dynamics and neurotransmitter release. It helps in the docking and fusion of synaptic vesicles with the plasma membrane during exocytosis.

Is ARF5 protein ubiquitously expressed in all tissues? 02/01/2017

es, ARF5 is expressed in a wide range of tissues and cell types, indicating its importance in fundamental cellular processes.

Does ARF5 play a role in cancer metastasis or tumor progression? 08/24/2016

ARF5 has been implicated in cancer metastasis and tumor progression. It can regulate processes such as cell migration, invasion, and cytoskeletal remodeling, which are involved in cancer metastasis. Dysregulation of ARF5 activity may contribute to the invasive behavior of cancer cells.

Are there any known ARF5-related genetic mutations associated with human diseases? 06/22/2016

Yes, mutations in the ARF5 gene have been identified in individuals with developmental disorders, such as intellectual disability and autism spectrum disorders. These mutations may affect ARF5 function and disrupt cellular processes involved in neuronal development and function.

Can ARF5 protein be targeted for therapeutic intervention in certain diseases? 05/25/2016

Targeting ARF5 protein could have therapeutic potential in diseases involving dysregulated membrane trafficking or cellular processes that ARF5 is involved in. However, further research is needed to fully understand the mechanisms and consequences of modulating ARF5 activity before it can be considered as a specific therapeutic target.

Are there any known post-translational modifications that can affect ARF5 protein function? 05/01/2016

Yes, ARF5 can undergo post-translational modifications such as phosphorylation, acetylation, and lipid modifications, which can modulate its activity, localization, and interaction with effector proteins.

Are there any known protein-protein interactions involving ARF5? 04/28/2016

Yes, ARF5 can interact with various proteins, such as ARFGAP1, ARFGAP3, and ARFIP2, to regulate its localization, activation, and downstream signaling.

Customer Reviews (8)

Write a review
Reviews
11/13/2022

    Their commitment to providing technical support is unparalleled, and their expertise can prove invaluable in navigating any challenges or troubleshooting that may arise during my experiments.

    11/09/2022

      the ARF5 Protein's applicability in protein electron microscopy structure analysis is remarkable.

      01/25/2022

        Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

        10/12/2021

          Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

          09/27/2021

            This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

            02/22/2021

              This commitment to staying at the forefront of research translates directly to the quality and performance of the ARF5 protein in my trials.

              05/11/2016

                They monitor the latest advancements in the field and incorporate new findings into the production and characterization of the protein.

                05/08/2016

                  the ARF5 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

                  Ask a Question for All ARF5 Products

                  Required fields are marked with *

                  My Review for All ARF5 Products

                  Required fields are marked with *

                  logo

                  FOLLOW US

                  Terms and Conditions        Privacy Policy

                  Copyright © 2024 Creative BioMart. All Rights Reserved.

                  Contact Us

                  • /

                  Stay Updated on the Latest Bioscience Trends