ARHGAP27
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Official Full Name
Rho GTPase activating protein 27
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Overview
Rho (see ARHA; MIM 165390)-like small GTPases are involved in many cellular processes, and they are inactive in the;GDP-bound state and active in the GTP-bound state. GTPase-activating proteins, such as ARHGAP27, inhibit Rho-like;proteins by stimulating their intrinsic GTPase activity (Katoh and Katoh, 2004 (PubMed 15492870)). -
Synonyms
ARHGAP27; Rho GTPase activating protein 27; SH3 domain containing 20 , SH3D20; rho GTPase-activating protein 27; CAMGAP1; FLJ43547; SH3P20; SH3 domain containing 20; SH3 domain-containing protein 20; rho-type GTPase-activating protein 27; CIN85-associated;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ARHGAP27-8740HCL | Recombinant Human ARHGAP27 293 Cell Lysate | HEK293 | N/A |
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| Human | ARHGAP27-6206H | Recombinant Human ARHGAP27 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | ARHGAP27-1866M | Recombinant Mouse ARHGAP27 Protein | Mammalian Cell | His |
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| Mouse | ARHGAP27-676M | Recombinant Mouse ARHGAP27 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Arhgap27-1685M | Recombinant Mouse Arhgap27 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | ARHGAP27-676M-B | Recombinant Mouse ARHGAP27 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ARHGAP27-766R | Recombinant Rat ARHGAP27 Protein | Mammalian Cell | His |
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| Rat | ARHGAP27-422R | Recombinant Rat ARHGAP27 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ARHGAP27-422R-B | Recombinant Rat ARHGAP27 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGAP27 Related Articles
ARHGAP27 involved in several pathways and played different roles in them. We selected most pathways ARHGAP27 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ARHGAP27 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP27 itself. We selected most functions ARHGAP27 had, and list some proteins which have the same functions with ARHGAP27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | TBC1D15;RGS6;RGS21;RASAL1;RGS3A;RGS12B;DEPDC1A;STXBP5L;ARHGAP28 |
| SH3 domain binding | NCKIPSD;CD3E;GRB2;LYN;FMN1;ARHGAP31;INPPL1B;FAM125A;TOM1L1 |
ARHGAP27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP27 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP27.
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- Q&As
- Reviews
Q&As (14)
Ask a questionCurrently, there are no known protein isoforms of ARHGAP27. However, alternative splicing events may give rise to potential isoforms that have not yet been characterized.
As of now, there are no specific animal models available that solely focus on ARHGAP27. However, mouse models with altered Rho GTPase signaling or cytoskeletal dynamics could potentially help in studying ARHGAP27's function indirectly.
At present, there is limited information on the involvement of ARHGAP27 in immune system function. Further research is necessary to determine if ARHGAP27 plays a role in immune responses or immune cell function.
ARHGAP27 has been found to be widely expressed across different tissues in the body. It has been detected in various cell types, including neurons, endothelial cells, fibroblasts, and immune cells.
Limited research has been done on the role of ARHGAP27 in cancer. However, some studies have shown altered expression of ARHGAP27 in certain cancer types, suggesting its potential involvement in cancer development and progression. Further investigation is needed to fully understand its role in cancer biology.
The specific role of ARHGAP27 in neuronal development or synaptic function is not well characterized. More research is needed to determine its potential involvement in these processes.
Currently, there is limited information on the regulation of ARHGAP27 expression by external factors or stimuli. Further studies are required to determine if its expression can be influenced by specific cellular signaling pathways or environmental cues.
Currently, there are no known genetic disorders specifically linked to mutations in the ARHGAP27 gene.
The involvement of ARHGAP27 in cell division or cell proliferation is not well established. While it has been implicated in regulating cytoskeletal dynamics, more research is needed to determine if it plays a direct role in these processes.
ARHGAP27 contains a RhoGAP domain, which suggests its involvement in regulating the activity of Rho GTPases. Additionally, it has a coiled-coil domain, which may be important for protein-protein interactions.
Currently, there are no specific studies directly linking ARHGAP27 to neurological disorders or neurodegeneration. However, given its role in cytoskeletal dynamics and potential involvement in neuronal development, further research may shed light on its relevance in these conditions.
Currently, there is no known therapeutic targeting of ARHGAP27. However, further research into its function and involvement in diseases may suggest potential therapeutic strategies in the future.
Yes, ARHGAP27 has been found to interact with various proteins involved in cell signaling and cytoskeletal organization. Some of its known binding partners include Rho GTPases, such as RhoA and Cdc42, as well as proteins involved in actin nucleation and polymerization.
ARHGAP27 is believed to play a role in regulating actin cytoskeleton dynamics and cell migration, based on its interaction with Rho GTPases. However, the exact cellular processes it regulates are still being investigated.
Customer Reviews (8)
Write a reviewTheir team of experts is readily available to address any queries or concerns I may have regarding the ARHGAP27 protein.
Their team of experts is readily available to address any concerns or queries I may have regarding the ARHGAP27 protein.
when employed in Western Blotting experiments, the ARHGAP27 protein consistently generates sharp and well-defined protein bands, enabling precise visualization and analysis of protein expression.
I highly recommend the use of the ARHGAP27 protein in various experimental applications.
the manufacturer's supply management capabilities assure a seamless and continuous provision of the ARHGAP27 protein.
The ARHGAP27 protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.
the ARHGAP27 protein has been successfully utilized in protein electron microscopy structure analysis, providing valuable insights into molecular structures and interactions.
Considering its outstanding performance across multiple assays, I confidently endorse the inclusion of the ARHGAP27 protein in diverse research studies.
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