ARL5A
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Official Full Name
ADP-ribosylation factor-like 5A
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Overview
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. -
Synonyms
ARL5A; ADP-ribosylation factor-like 5A; ADP ribosylation factor like 5 , ARL5; ADP-ribosylation factor-like protein 5A; ADP ribosylation factor like 5; ADP ribosylation factor like 5A; ADP ribosylation factor like protein 5; ADP ribosylation factor like protein 5A; ARFLP 5; ARFLP5; ARL 5; ARL 5A; ARL5; OTTHUMP00000162713; OTTHUMP00000207220; OTTHUMP00000207221; ADP-ribosylation factor-like 5; ADP-ribosylation factor-like protein 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ARL5A involved in several pathways and played different roles in them. We selected most pathways ARL5A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARL5A has several biochemical functions, for example, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL5A itself. We selected most functions ARL5A had, and list some proteins which have the same functions with ARL5A. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | ADSS;RHOT1A;RND3A;ARL4CA;ARL3;RAB39BA;RAB2B;ARL5A;ARF3B |
ARL5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL5A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL5A.
pi3p
- Q&As
- Reviews
Q&As (12)
Ask a questionWhile ARL5A is primarily associated with cellular trafficking processes, it can indirectly influence signal transduction pathways by modulating the function of primary cilia. Primary cilia play a critical role in sensing extracellular signals and transmitting them to intracellular signaling pathways, and ARL5A contributes to ciliary function.
Currently, there are no known therapeutic interventions specifically targeting ARL5A. However, the understanding of its role in diseases, particularly in ciliary dysfunction disorders, may pave the way for future therapeutic strategies aimed at modulating ARL5A activity or related pathways.
Yes, studies suggest that the expression of ARL5A can be regulated during cellular development and differentiation. Its levels may vary in different tissues and cell types, indicating potential roles in developmental processes.
Yes, ARL5A can undergo post-translational modifications, including prenylation. Prenylation involves the addition of a lipid group (such as a farnesyl or geranylgeranyl group) to the C-terminus of the protein, which aids in its membrane targeting and function.
Yes, several proteins have been identified as interacting partners of ARL5A. Some examples include ARF-like protein 6 (ARL6), ARL6-interacting protein (ARL6IP1), and Arfaptin-2 (ARFIP2), which interact with ARL5A to regulate vesicle trafficking and ciliary function.
Animal models with mutations or deletions in the Arl5a gene have been generated, primarily in mice, to study its function and possible disease associations. These models can provide valuable insights into the role of ARL5A in cellular processes and disease pathogenesis.
Although ARL5A's specific involvement in neurodegenerative disorders is not well-established, disruption of cellular trafficking and protein sorting, which are regulated by ARL5A, can contribute to the pathology of various neurodegenerative diseases.
ARL5A is involved in various cellular processes, including the formation and maintenance of primary cilia, a cellular organelle involved in signal transduction. It also plays a role in intracellular trafficking, specifically in the regulation of protein sorting, vesicle formation, and protein transport between compartments.
Yes, mutations in the ARL5A gene have been identified in individuals with Bardet-Biedl syndrome, suggesting a disease-specific involvement of ARL5A. These mutations can disrupt the normal function of ARL5A and impair cellular processes dependent on ciliary function.
The activity of ARL5A is regulated by the binding and hydrolysis of GTP (guanosine triphosphate). When bound to GTP, ARL5A is in its active state, promoting cellular processes. It hydrolyzes GTP to GDP (guanosine diphosphate), leading to inactivation and release from its target proteins.
Studies involving ARL5A knockdown or knockout have demonstrated several functional consequences. These include impaired ciliogenesis, disrupted vesicular trafficking, altered protein sorting, and abnormal cellular signaling. The absence or depletion of ARL5A can lead to cellular dysfunction and contribute to disease phenotypes.
ARL5A has been linked to certain diseases and pathological conditions. Mutations in ARL5A have been associated with Bardet-Biedl syndrome, a rare genetic disorder characterized by various developmental abnormalities and ciliary dysfunction.
Customer Reviews (8)
Write a reviewmanufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.
When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize ARL5A protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.
The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.
the manufacturer can contribute to the research process by providing top-quality ARL5A protein that meets rigorous standards of purity, stability, and reliability.
Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
As a researcher, utilizing ARL5A protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.
ARL5A, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.
If the need arises for larger quantities of ARL5A protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
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