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CYP19A1

  • Official Full Name

    cytochrome P450, family 19, subfamily A, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP19A1-432H Recombinant Human CYP19A1 protein E.coli N/A 1 - 181 aa
Human ARO-3637H Recombinant Human ARO, His-tagged E.coli His 503
Human CYP19A1-26393TH Recombinant Human CYP19A1 Wheat Germ N/A 219 amino acids
Human CYP19A1-26421TH Recombinant Human CYP19A1 Wheat Germ N/A 182 amino acids
Human CYP19A1-145H Recombinant Human CYP19A1 Mammalian Cell His
Human CYP19A1-158H Recombinant Human CYP19A1 protein, GST-tagged Wheat Germ GST
Human CYP19A1-7127HCL Recombinant Human CYP19A1 293 Cell Lysate HEK293 N/A
Human CYP19A1-1732HFL Recombinant Full Length Human CYP19A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP19A1-0938H Recombinant Human CYP19A1 protein, His-tagged E.coli His 1-503aa
Human CYP19A1-548H Recombinant Human CYP19A1 Protein, His-tagged E.coli His Leu196~Val373
Human CYP19A1-698H-B Recombinant Human CYP19A1 Protein Pre-coupled Magnetic Beads HEK293
Human CYP19A1-301H Recombinant Human CYP19A1 protein, His-tagged E. coli His 241-400 aa
Human CYP19A1-112HF Recombinant Full Length Human CYP19A1 Protein In Vitro Cell Free System 219 amino acids
Human CYP19A1-300H Recombinant Human CYP19A1 protein, GST-tagged E. coli GST 241-400 aa
Human CYP19A1-698H Recombinant Human CYP19A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP19A1-302H Recombinant Human CYP19A1 protein, His-tagged E. coli His 1-181 aa
Human CYP19A1-1911H Recombinant Human CYP19A1 Protein (Leu196-Val373), His tagged E.coli His Leu196-Val373
Mouse CYP19A1-4148M Recombinant Mouse CYP19A1 Protein Mammalian Cell His
Mouse Cyp19a1-368M Recombinant Mouse Cyp19a1 Protein, His-tagged E.coli N-His Leu196-Val373
Mouse CYP19A1-2126M Recombinant Mouse CYP19A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CYP19A1-2126M-B Recombinant Mouse CYP19A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cyp19a1-2411M Recombinant Mouse Cyp19a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Cyp19a1-369R Recombinant Rat Cyp19a1 Protein, His-tagged E.coli N-His Leu196-Val373
Chicken CYP19A1-1157C Recombinant Chicken CYP19A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP19A1 Related Articles

CYP19A1 involved in several pathways and played different roles in them. We selected most pathways CYP19A1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Endogenous sterols, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP19A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsFDX1;GGT6;CYP2R1;CYP2A7;CYP46A1;CYP3A7-CYP3AP1;NCOA2;AS3MT;CYP2C18
Cytochrome P450 - arranged by substrate typeCYP4B1;CYP2B6;CYP2U1;CYP4F12;CYP2K6;CYP3A7-CYP3AP1;CYP27A1;CYP51A1;CYP4F22
Endogenous sterolsCYP8B2;CYP21A2;CYP7A1;CYP11B1;CYP46A1;CYP19A1;CYP27A1;CYP17A1;FDXR
Estrogen biosynthesisCYP19A1;AKR1B15;HSD17B11
FSH signaling pathwayCYP19A1;CGA;AREG
Integrated Breast Cancer PathwayAHR;UBE2F;USP38;DHTKD1;NAB1;GRN;MYT1;SMARCA4;PLK3
Metabolic pathwaysGAD2;PTGESL;DAO.2;UPRT;ACAA2;ADC;GLULB;DGKZ;PGM2
MetabolismCYB5R3;AKR1C2;BCKDK;ETFB;GLTPA;APOA4B.2;CIAO1;AKR1C4;B3GNT2A

CYP19A1 has several biochemical functions, for example, aromatase activity, electron carrier activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP19A1 itself. We selected most functions CYP19A1 had, and list some proteins which have the same functions with CYP19A1. You can find most of the proteins on our site.

Function Related Protein
aromatase activityCYP1A2;CYP4Z1;CYP2F1;CYP1A1;CYP2S1;CYP2H1;CYP2C50;CYP19A1;CYP2D10
electron carrier activityETFA;SDHB;UQCR11;AOX3;ACAD8;AKR7A3;GCDHA;GLRX3;AKR7A2
heme bindingCYP21A2;CYP2K6;CYP46A1.2;CYBA;CYP2K16;CYP2K17;HBA2;CYP2J2;NGB
iron ion bindingCYP1A1;CYP2A6;CYP2D6;MFI2;CYP4F12;HBE1;CYP2A13;CYP4V7;JMJD6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2J5;CYP2AA7;CYP2D9;CYP2AA8;CYP2R1;CYP2K19;CYP2C54;CYP2B19;CYP2K22
oxygen bindingHBAA;CYP3A5;TH;CYP2P10;HBBE1.1;CYP2F1;CYP2C50;CYP2B19;CYP2AD3

CYP19A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP19A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP19A1.

A2M

Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).
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