ARR3
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Official Full Name
arrestin 3, retinal (X-arrestin)
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Overview
Arrestin-C also known as retinal cone arrestin-3 is a protein that in humans is encoded by the ARR3 gene. -
Synonyms
ARR3; arrestin 3, retinal (X-arrestin); arrestin-C; arrestin 4; ARRX; ARRC_HUMAN; Arrestin 3 retinal; C arrestin; C-arrestin; CAR; cArr; Cone arrestin; Retinal cone arrestin 3; Retinal cone arrestin-3; X arrestin; X-arrestin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Chicken
- Human
- Rat
- E.Coli or Yeast
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARR3-854H | Recombinant Human ARR3 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARR3-129HCL | Recombinant Human ARR3 cell lysate | N/A | |||
Human | ARR3-28HF | Recombinant Full Length Human ARR3 Protein | In Vitro Cell Free System | 359 amino acids | ||
Human | ARR3-1243HF | Recombinant Full Length Human ARR3 Protein, GST-tagged | In Vitro Cell Free System | GST | 359 amino acids | |
Human | ARR3-26078TH | Recombinant Human ARR3 | Wheat Germ | N/A | 359 amino acids | |
Human | ARR3-26077TH | Recombinant Human ARR3 | Wheat Germ | N/A | 359 amino acids | |
Rat | Arr3-3641R | Recombinant Rat Arr3, GST-tagged | E.Coli or Yeast | GST | 92 | |
Chicken | ARR3-3694C | Recombinant Chicken ARR3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARR3 involved in several pathways and played different roles in them. We selected most pathways ARR3 participated on our site, such as CXCR4-mediated signaling events, Thromboxane A2 receptor signaling, Visual signal transduction: Cones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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CXCR4-mediated signaling events | CFL1;DNM1;PAG1;ARR3;ADRBK1;MAPKAP1;CSK;JAK2;CRK |
Thromboxane A2 receptor signaling | ADRBK2;SLC9A3R1;ARR3 |
Visual signal transduction: Cones | CNGA3;RDH12;RLN1;ARR3;GRK7 |
ARR3 has several biochemical functions, for example, opsin binding, phosphoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARR3 itself. We selected most functions ARR3 had, and list some proteins which have the same functions with ARR3. You can find most of the proteins on our site.
Function | Related Protein |
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opsin binding | ARR3;IFT20;SAG |
phosphoprotein binding | TOX3;CBX4;RB1;MS4A2;CSNK1D;YWHAB;TBL2;PAFAH1B1;CACNB2 |
protein binding | CHRNA5;TMEM8A;STAMBPL1;MED23;TSGA10;SOAT1;ALDH7A1;RAD9;IL2RG |
protein domain specific binding | NFASC;THRA;ERCC1;STX1A;STMN3;NLRP1;BHLHE40;MTOR;LIN7C |
ARR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARR3.
ZNF496; PLK4; ZBTB43; ARRB1; DVL2; MAP2K7; CAPNS1; GNMT; RCOR2
- Q&As
- Reviews
Q&As (6)
Ask a questionWhile ARR3 is primarily expressed in cone cells, studies have suggested that it may have additional roles in non-visual tissues. These include modulating GPCR signaling in other cell types, such as neurons and immune cells, and potentially contributing to cellular processes like synaptic transmission and immune response regulation.
There is ongoing research exploring the potential use of ARR3 as a biomarker for certain eye diseases. Changes in the expression or localization of ARR3 have been observed in conditions like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), suggesting its potential as a diagnostic or prognostic indicator in these diseases.
ARR3 is a subtype of arrestin proteins that is specifically expressed in cone cells of the retina. It differs from other arrestin proteins, such as ARR1 (also known as arrestin-1), which is expressed in rod cells and plays a similar role in the desensitization of rod photoreceptors.
The expression and activity of ARR3 are tightly regulated to ensure proper visual function. Several factors, including light exposure, intracellular calcium levels, and protein kinases, can impact ARR3's localization, binding affinity, and activity, ultimately modulating its efficiency in desensitizing cone opsins.
Mutations or dysregulation of ARR3 have been linked to certain visual disorders, such as cone dystrophy and night blindness. These conditions are characterized by impaired cone cell function and visual impairment, underscoring the importance of ARR3 in maintaining normal cone cell physiology.
By binding to cone opsins, ARR3 helps to reset the signaling cascade after absorption of light, allowing the cones to respond to subsequent visual stimuli. This process is crucial for maintaining proper visual sensitivity and preventing adaptation or saturation of the photoreceptor cells.
Customer Reviews (3)
Write a reviewThe ARR3 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With the ARR3 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
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