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ARX

  • Official Full Name

    aristaless related homeobox

  • Overview

    This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Mutations in this gene cause X-linked mental retardation and epilepsy.
  • Synonyms

    ARX; aristaless related homeobox; mental retardation, X linked 29 , mental retardation, X linked 32 , mental retardation, X linked 33 , mental retardation, X linked 36 , mental retardation, X linked 38 , mental retardation, X linked 43 , mental reta;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARX-876H Recombinant Human ARX protein, GST-tagged Wheat Germ GST
Human ARX-2820H Recombinant Human ARX Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARX-547H Recombinant Human ARX Protein, His-tagged E.coli His Ser25~Asp246
Human ARX-4868H Recombinant Human ARX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ARX-1996M Recombinant Mouse ARX Protein Mammalian Cell His
Mouse ARX-767M-B Recombinant Mouse ARX Protein Pre-coupled Magnetic Beads HEK293
Mouse Arx-652M Recombinant Mouse Arx Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ARX-767M Recombinant Mouse ARX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARX-812R Recombinant Rat ARX Protein Mammalian Cell His
Rat ARX-468R-B Recombinant Rat ARX Protein Pre-coupled Magnetic Beads HEK293
Rat ARX-468R Recombinant Rat ARX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARX involved in several pathways and played different roles in them. We selected most pathways ARX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ARX has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARX itself. We selected most functions ARX had, and list some proteins which have the same functions with ARX. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCRAMP1L;HBP1;NKX2.2A;FOSB;G3BP1;NKX6-1;H1M;THAP5;NR2F5
RNA polymerase II distal enhancer sequence-specific DNA bindingNR5A1;NONO;SPI1;ARX;ESRRB;NR1H4;PROP1;ZBTB16;ARID3B
RNA polymerase II transcription factor activity, sequence-specific DNA bindingSP2;NPAS4;FOXB1A;TAL2;RUNX3;ZNF434;SPI1;MEF2A;RUNX2A
chromatin bindingPDX1;TCF7L1A;MLH3;TLE4;SP140;NEUROG1;ARID5A;PHF21B;C10orf119
sequence-specific DNA bindingHOXC10;ELF2B;NR6A1B;DMBX1;E2F5;MAF;NKX2-4;ESX1;RBPJ
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific bindingBACH2;MSC;ARX;PROP1;ZBTB16;PAX4;BACH1;GZF1

ARX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARX here. Most of them are supplied by our site. Hope this information will be useful for your research of ARX.

  • Q&As
  • Reviews

Q&As (8)

Ask a question
How does a mutation in the ARX gene affect brain development? 04/18/2023

Mutations in the ARX gene disrupt normal brain development, leading to impaired neuronal migration, abnormal cortical structures, and cognitive and motor impairments.

Does the ARX protein have DNA-binding abilities? 02/03/2023

Yes, the ARX protein contains a DNA-binding domain called the homeobox domain, allowing it to bind to specific DNA sequences and regulate gene transcription.

Is the ARX protein involved in epilepsy? 12/21/2022

Yes, mutations in the ARX gene are associated with a higher risk of epilepsy, particularly West syndrome, a specific type of early-onset epilepsy.

Can alterations in ARX gene expression lead to intellectual disabilities? 05/04/2021

Yes, mutations or alterations in ARX gene expression can result in intellectual disabilities, ranging from mild to severe, depending on the type of mutation and its impact on brain development.

Is the ARX protein involved in the development of other organs besides the brain? 11/19/2020

Yes, the ARX protein also plays a role in the development of other organs, including the pancreas, testes, and skeletal muscles.

Does the ARX protein interact with other proteins? 09/17/2018

Yes, the ARX protein interacts with various co-factors, transcriptional regulators, and chromatin remodeling proteins to regulate gene expression during brain development.

Are there any disorders associated with mutations in the ARX gene? 10/15/2017

Yes, mutations in the ARX gene are associated with a range of neurological disorders, such as X-linked lissencephaly with abnormal genitalia (XLAG), Partington syndrome, and West syndrome.

Does the ARX protein have a role in hormone regulation? 06/27/2017

Yes, the ARX protein is involved in the development and function of the pancreas, where it regulates the production of insulin and glucagon, hormones involved in blood sugar regulation.

Customer Reviews (3)

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Reviews
02/26/2023

    This protein has proven to be of great utility in protein electron microscopy structure analysis.

    11/05/2020

      I highly recommend the ARX Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

      07/24/2017

        The ARX Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

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