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ASAP1

  • Official Full Name

    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

  • Overview

    This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; DDEF1, development and differentiation enhancing factor 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; centaurin; beta 4; CENTB4; KIAA1249; PAP; ZG14P; DEF-1; cent;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rat
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ASAP1-881H Recombinant Human ASAP1 protein, GST-tagged Wheat Germ GST
Human ASAP1-8668HCL Recombinant Human ASAP1 293 Cell Lysate HEK293 N/A
Human ASAP1-1259HF Recombinant Full Length Human ASAP1 Protein, GST-tagged In Vitro Cell Free System GST 36 amino acids
Mouse ASAP1-2002M Recombinant Mouse ASAP1 Protein Mammalian Cell His
Mouse ASAP1-772M Recombinant Mouse ASAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ASAP1-772M-B Recombinant Mouse ASAP1 Protein Pre-coupled Magnetic Beads HEK293
Rat ASAP1-816R Recombinant Rat ASAP1 Protein Mammalian Cell His
Rat ASAP1-472R Recombinant Rat ASAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ASAP1-472R-B Recombinant Rat ASAP1 Protein Pre-coupled Magnetic Beads HEK293
Bovine ASAP1-3617B Recombinant Bovine ASAP1, His-tagged E.Coli or Yeast His 1129
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ASAP1 Related Articles

ASAP1 involved in several pathways and played different roles in them. We selected most pathways ASAP1 participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisCYTH2;HSPA2;RAB11BB;IGF1RA;MVB12B;ASAP2;SPG20;PIP5K1A;VPS26A
Fc gamma R-mediated phagocytosisSYK;PAK1;RPS6KB2;PPAP2A;FCGR2A;PLCG2;FCGR3A;PIK3CB;LIMK2

ASAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP1 itself. We selected most functions ASAP1 had, and list some proteins which have the same functions with ASAP1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityRANBP1;BNIP2;DOCK1;TBC1D2B;ARHGAP8;CHN2;DEPDC1;AXIN2;TBC1D9B
metal ion bindingGMEB1;VAV3B;ZFP110;PON2;CYP21A1;GNAI3;EGR3;MUS81;LHX1B
phosphatidylinositol-3,4,5-trisphosphate bindingNRGN;ANXA8;ZFYVE16;ARAP3;RAG2;KIF16B;ARAP1;AKT1;GBF1
phosphatidylinositol-4,5-bisphosphate bindingPFN1;COMMD1;TWF1;FAM21C;AMER2;ASAP1;RPH3A;SLC9A1;ANXA8
protein bindingPLP1;BOLL;SMARCA2;NAA35;RALGAPA1;NFAT5;BLVRA;ARHGEF40;COG4

ASAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP1.

GRB2; CTTN; SH3KBP1

Schwenteit, J; Bogdanovic, X; et al. Toxoid construction of AsaP1, a lethal toxic aspzincin metalloendopeptidase of Aeromonas salmonicida subsp achromogenes, and studies of its activity and processing. VETERINARY MICROBIOLOGY 162:687-694(2013).
Li, HH; Li, Q; et al. WNT1-Inducible Signaling Pathway Protein 1 Contributes to Ventilator-Induced Lung Injury. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 47:528-535(2012).
  • Q&As
  • Reviews

Q&As (7)

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How does ASAP1 participate in actin cytoskeleton remodeling? 10/14/2022

ASAP1 binds to actin-binding proteins and actin regulatory proteins, enabling it to regulate actin dynamics and cytoskeleton rearrangements in response to cellular signaling.

What cellular processes are regulated by ASAP1's Arf-GAP activity? 07/05/2022

ASAP1's Arf-GAP activity influences processes such as endocytosis, exocytosis, membrane recycling, and protein trafficking.

Is ASAP1 expression altered in cancer? 04/04/2022

Yes, ASAP1 expression levels can be dysregulated in certain cancer types, leading to increased invasiveness and poor prognosis.

Does ASAP1 play a role in cancer development or progression? 07/07/2021

Yes, ASAP1 has been implicated in cancer progression, promoting cell migration, invasion, and metastasis.

Where is ASAP1 primarily localized within cells? 03/28/2021

ASAP1 is found predominantly at the plasma membrane, where it participates in various cellular activities.

What other proteins interact with ASAP1? 03/02/2020

ASAP1 interacts with various proteins, including members of the Arf family, components of the endocytic machinery, regulators of actin dynamics, and other signal transduction molecules.

Are there any mutations or genetic variations associated with ASAP1? 06/13/2018

Mutations or genetic variations in ASAP1 have not been extensively reported, but further research is required to explore their potential associations.

Customer Reviews (3)

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Reviews
12/25/2020

    I have found the ASAP1 Protein to be highly stable, enabling long-term experiments without compromising its performance.

    05/08/2019

      One aspect that sets the ASAP1 Protein apart is the excellent technical support provided by the manufacturer.

      01/09/2016

        The ASAP1 Protein is an exceptional product that fully meets my experimental needs.

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