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Asparaginase

Official Full Name

Asparaginase
Overview

Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. It is marketed under the brand name Elspar, to treat acute lymphoblastic leukemia (ALL) and is also used in some mast cell tumor protocols. Unlike other chemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation. The rationale behind asparaginase is that it takes advantage of the fact that ALL cellsare unable to synthesize the non-essential amino acidasparaginewhereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine.
Synonyms

Asparaginase;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
	Kit-0108	Asparaginase Activity Assay Kit II		N/A		Inquiry

Asparaginase Related Articles

Asparaginase involved in several pathways and played different roles in them. We selected most pathways Asparaginase participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Asparaginase were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Asparaginase has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Asparaginase itself. We selected most functions Asparaginase had, and list some proteins which have the same functions with Asparaginase. You can find most of the proteins on our site.

Function	Related Protein

Asparaginase has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Asparaginase here. Most of them are supplied by our site. Hope this information will be useful for your research of Asparaginase.

Henriksen, LT; Harila-Saari, A; et al. PEG-Asparaginase Allergy in Children With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Protocol. PEDIATRIC BLOOD & CANCER 62:427-433(2015).

Verhoef, JJF; Carpenter, JF; et al. Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics. DRUG DISCOVERY TODAY 19:1945-1952(2014).