atp1b1
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  • Official Full Name
  • ATPase, Na+/K+ transporting, beta 1 polypeptide
  • Background
  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
  • Synonyms
  • ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATP1B; sodium/potassium-transporting ATPase subunit beta-1; adenosinetriphosphatase; Na, K-ATPase beta-1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; sodium/potassium-dependent ATPase beta-1 su
Cat.#:Atp1b1-462MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Atp1b1 Protein, His-tagged
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Cat.#:ATP1B1-10007HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1B1, GST-tagged
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Cat.#:ATP1B1-2279HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1B1 protein, His-tagged
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Cat.#:ATP1B1-246HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATP1B1, His tagged
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Cat.#:ATP1B1-965HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP1B1 protein, GST-tagged
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Cat.#:ATP1B1-2116MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP1B1 Protein
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Cat.#:ATP1b1-3766MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ATP1b1, His-tagged
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Cat.#:ATP1B1-856RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP1B1 Protein
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Cat.#:ATP1B1-321CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ATP1B1 Protein, His-tagged
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Cat.#:ATP1B1-449RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATP1B1 Protein, His-tagged
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Cat.#:ATP1B1-7069CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP1B1
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Cat.#:ATP1B1-919HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATP1B1 cell lysate
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Involved Pathway

ATP1B1 involved in several pathways and played different roles in them. We selected most pathways ATP1B1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
ATP1B3; ATP1B1; GNAI1; GTF2IRD1; INS1; ATP2A1; AGTR1B; AKT2; INSR; PPP1R12A
cAMP signaling pathway
RAC1; PRKACG; CNGA1; GRIA1; HCAR3; CAMK2A; CALM2; GRIN2C; GRIN3A; ATP2A2
Cardiac muscle contraction
ACTC1A; ATP1B3A; ATP2A2; CACNA2D1A; TPM2; COX8C; CACNG7A; ATP1A3B; ATP1A2; UQCR10
Adrenergic signaling in cardiomyocytes
MAPK14; TNNC1A; SCN4BA; MAPK12; CREB3L4; SCN1B; ADRB3A; TNNT2; PPP2R2CA; PRKACA
Insulin secretion
RAB3A; VAMP2; GLP1R; ATP1A3; PLCB4; CREB3L3; ATF4; PDX1; KCNMB4; FXYD2
Thyroid hormone synthesis
ITPR3; ASGR1; GPX3; TSHB; ATP1B3; ATP1A2; PLCB4; GPX7; GPX6; IYD
Thyroid hormone signaling pathway
KAT2A; PIK3CG; AKT2; HDAC2; PDPK1; SLCO1C1; HIF1A; HRAS; PIK3CD; PRKCA
Aldosterone-regulated sodium reabsorption
PDPK1; ATP1A4; FXYD2; IRS1; ATP1B3; PIK3CB; KCNJ1; ALPHA-ENAC; INS2; SCNN1G
Endocrine and other factor-regulated calcium reabsorption
PRKACB; ATP1A2; ATP1A4; ATP1B2; KLK2; PLCB3; ATP1A3; DNM2; KLK1B8; FXYD2
Proximal tubule bicarbonate reclamation
PCK1; ATP1B1; Car4; FXYD2; GLS2; SLC38A3; ATP1A2; GLUD2; MDH1; SLC4A4
Salivary secretion
Slc4a2; CAMP; ATP1B1; CAP18; CALML3; ATP1A3; PRH1; LPO; PRKG2; PRKACG
Gastric acid secretion
PLCB3; GAST; ATP1A2; ATP1B4; Car2; KCNK10; PLCB2; Slc4a2; KCNQ1; EZR
Pancreatic secretion
ITPR3; CTRB1; PLCB3; PLA2G2D; TPCN2; CPB2; CTRL; RYR2; AMY2A; CLCA1
Carbohydrate digestion and absorption
AMY2B; FXYD2; AMY2A4; SLC2A5; G6PC; PIK3R2; PRKCB; SI; PIK3R1; HK3
Protein digestion and absorption
SLC3A2; SLC7A8; KCNJ13; ACE2; COL27A1; PRSS1; CPA2; KCNK5; SLC8A2; FXYD2
Bile secretion
SLC22A8; ABCC3; SLC9A3; SLC2A1; ATP1A4; ADCY8; ATP1B2; SLC27A5; SLC9A1; ABCB11
Mineral absorption
ATP2B1; SLC26A3; ATP1B1; SLC46A1; Trf; ATOX1; MT1F; SLC11A1; STEAP1; STEAP2

Protein Function

ATP1B1 has several biochemical functions, for example, contributes_to ATP binding, ATPase activator activity, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B1 itself. We selected most functions ATP1B1 had, and list some proteins which have the same functions with ATP1B1. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ATP binding
Related Protein ABCG8; ATP1B1; ATP1A2; MSH6; MSH2; SFRP5; ATP5D
Function ATPase activator activity
Related Protein ATP1B3; AHSA1L; DNAJB1; ATP1B1; AHSA2; AHSA1; DNAJB6; DNAJC10; DNAJC24; DNAJC19
Function contributes_to ATPase activity
Related Protein ATP5L; ATP5D; ATP5J2; RUVBL2; ATP5C1; SFRP5; PPP2R4; ATP6V1H; ATP5H; ATP5J
Function ATPase binding
Related Protein PKD2; ANK1; GABARAPL2; SVIP; SELS; TCIRG1; ATPIF1B; ESR1; DRD1A; DNAJB1
Function MHC class II protein complex binding
Related Protein PKM2; HLA-DMB; CD81; HLA-DRB1; HSPA8; HLA-DMA; CD74; ANXA11; PKM; ATP1B1
Function contributes_to drug binding
Related Protein PGGT1B; ATP1A2; ATP1B1
Function contributes_to potassium ion binding
Related Protein ATP1A2; ATP1B1
Function protein C-terminus binding
Related Protein PEX16; PABPC1; XRCC4; PXK; SNF8; TAE1; ZBTB16; OPRL1; VPS4A; MAP2K1
Function protein binding
Related Protein LYVE1; AHI1; NFATC2; SPSB3; PAIP1; RAB18; BEX5; PHB; KLF11; SIAH1A
Function contributes_to sodium ion binding
Related Protein ATP1A2; ATP1B1
Function contributes_to sodium:potassium-exchanging ATPase activity
Related Protein ATP1A2; ATP1A1; ATP1B2; ATP1B1; ATP1B3

Interacting Protein

ATP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B1.
SLC4A1; MLC1; NR3C1; SMAD2; DDAH2; CRIP2; PSME1; EZH2; RIF1; TRMT2A; KMT2B; ouabain

ATP1B1 Related Articles

Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).