ATP5A1
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
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Overview
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the same protein have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. -
Synonyms
ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle , ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non cardiac muscle like 2 , ATP5AL2, ATPM; ATP synthase subunit alpha, mitochondrial; ATP5A; hATP1; OMR; ORM; mitochondrial; ATP synthase alpha chain, mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2; ATP sythase (F1 ATPase) alpha subunit; ATP5AL2; ATPA_HUMAN; ATPM; Mitochondrial ATP synthetase oligomycin resistant; MOM2; MS502; OTTHUMP00000163475; ATP sythase (F1-ATPase) alpha subunit; mitochondrial ATP synthetase, oligomycin-resistant;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ATP5A1 Related Articles
ATP5A1 involved in several pathways and played different roles in them. We selected most pathways ATP5A1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Oxidative phosphorylation | NDUFB2;ATP6V1C1A;NDUFA9A;COX8C;NDUFB6;ATPV0E2;ATP6V1G1;ATP6V0C;ATP5D |
Metabolic pathways | ALDH18A1;DNMT3A;PYCR1B;PIGX;MCEE;ATP5O;ADSSL;ACLYA;PDHX |
Alzheimers disease | EIF2AK3;UQCRH;Casp3;PLCB4;COX7A1;ATP5A1;mt-Atp8;COX6B2;PPP3CB |
Parkinsons disease | NDUFS4;NDUFB1;COX7A2L;VDAC2;UBA1;SLC18A1;NDUFV2;VDAC1;GNAI1 |
Huntingtons disease | PLCB1;NDUFA3;ATP5G3;ITPR1;NDUFS6;GRM5;NDUFA6;SP1;NDUFA13 |
ATP5A1 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5A1 itself. We selected most functions ATP5A1 had, and list some proteins which have the same functions with ATP5A1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | HSPA4;ATAD3A;EHD4;TWF2;CMPK2;AURKA;ADCK1;ABCA13;SMYHC2 |
contributes_to ATPase activity | RFC3;ABCA7;ATP1A2;ATP5L;MSH6;ABCG8;ATP5E;RUVBL2;PPP2R4 |
MHC class I protein binding | LILRB2;ATP5B;PILRB2;LILRB1;TUBB;HLA-E;TAP1;TAPBP;DERL1 |
poly(A) RNA binding | TBCA;MTO1;DARS;CSNK1E;MRPS14;MKI67;ARHGEF1;PTBP1;DHX36 |
protein binding | TGFB1I1;DRD2;ATP1B2;RIPPLY3;BLOC1S4;SCIMP;MAPRE2;ZNF286A;CRB1 |
proton-transporting ATP synthase activity, rotational mechanism | ATP5A1;ATP5O;ATP5B;ATP6V0C;ATP5C1;ATP5E;ATP6AP1B;ATP6AP1 |
proton-transporting ATPase activity, rotational mechanism | ATP6V0E;ATP5C1;ATP6V1AA;ATP5E;ATP5A1;ATP6V0E1;ATP6V1H;ATP6V1A;ATP6V0E2 |
transmembrane transporter activity | SLC2A3A;ATP5O;SLC2A11B;SLC22A13;SLCO1D1;SLC22A23;SLC2A8;SLC2A13B;SLC22A7B.1 |
ATP5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5A1.
YWHAZ; VCAM1; SIRT3; CSNK2A1; TNFRSF1A; TNFRSF1B; ATP5F1; YWHAB; ACTB; YWHAG; BLOC1S1
- Q&As
- Reviews
Q&As (6)
Ask a questionATP5A1 interacts with other ATP synthase subunits and a variety of mitochondrial proteins (such as NADH dehydrogenase and chromosomal acyl-coa carboxylase) to participate in the process of energy metabolism.
The abnormal expression of ATP5A1 can be used as an important indicator for the diagnosis and prognosis of some neurodegenerative diseases, but it needs to be comprehensively analyzed in combination with other clinical and molecular biological results.
Mutations in ATP5A1 may lead to abnormal changes in its intracellular localization and function, thereby affecting mitochondrial neuroregulation and energy metabolism.
ATP5A1 participates in the regulation of cellular energy metabolism and mitochondrial function, and plays an important role in cell growth and development.
Yes, several studies have been devoted to the development of drugs that can regulate the activity of ATP5A1 to affect cellular energy metabolism and treat related diseases.
Yes, some studies have found that the expression pattern of ATP5A1 is related to the malignant degree and prognosis of liver cancer, bladder cancer, prostate cancer and other tumors.
Customer Reviews (3)
Write a reviewIt is not easy to be contaminated, and then stored.
The reproducibility of ATP5A1 is very good, with very consistent results in every experiment or application, benefiting from its high degree of stability and reproducibility.
Using ATP5A1 as a catalyst, the rate and yield of chemical reactions can be significantly increased with high catalytic efficiency.
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