AURKA
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Official Full Name
aurora kinase A
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Overview
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
AURKA; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; ARK-1; hARK1; aurora 2; Aurora-A kinase; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; serine/threonine-protein kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase aurora-A; protein phosphatase 1, regulatory subunit 47;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- S.frugiperda
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- AURKA Related Articles
AURKA involved in several pathways and played different roles in them. We selected most pathways AURKA participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | IGF1;BUB1;PPP3R1;ANAPC4;INS2;CALML5;PPP3CA;CALM3A;ANAPC13 |
AURKA has several biochemical functions, for example, ATP binding, histone serine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKA itself. We selected most functions AURKA had, and list some proteins which have the same functions with AURKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RUVBL2;SGK2;RFC5;DGKD;ABCC10;ALK;KSR2;NSFB;MAP2K2B |
| histone serine kinase activity | PRKAA1;AURKB;AURKC;ATM;AURKA;PRKAA2 |
| protein binding | SH2B2;ITGA7;TRAPPC5;UNC13D;PHAX;TEKT3;MALT1;RORB;KNDC1 |
| protein kinase activity | PKDCC;STK25A;SCYL1;SCYL2;NPR1;TRIM28;STK38A;CDK11A;TNK2B |
| protein kinase binding | GRB2;TPX2;PPP1R15A;SMAD3;CASP9;DLG1;ITGB2;HDAC4;FOXO3 |
| protein serine/threonine kinase activity | RPS6KA2;PRKACAB;ROCK2A;GM4922;SBK3;MAPK1;CASK;RIPK4;PRKD2 |
| protein serine/threonine/tyrosine kinase activity | PRKACA;MAP2K1;ACVR2B;PRKCG;TESK1;AURKC;DYRK4;AKT1;DYRK3 |
| ubiquitin protein ligase binding | TNFRSF14;UBE2H;HSPA1L;UBE2U;TUBB;DTX1;FZD8;CDC34A;JAK1 |
AURKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKA here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKA.
MYCN; TP73
- Q&As
- Reviews
Q&As (6)
Ask a questionAURKA protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, Plk1, TPX2, etc., to regulate the progression of cell cycle.
The protein plays an important role in the G2 and M phases of the cell cycle and is involved in the regulation of nuclear division, chromosome segregation, and cell mitosis.
AURKA protein may be involved in the regulation of apoptosis and DNA damage repair, but the specific mechanism needs to be further studied.
The activity is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
It is mainly localized in the cytoplasm and nucleus and is involved in cell cycle regulation and cell division processes.
This protein plays an important role in tumorigenesis, and its overexpression or mutation may lead to abnormal cell proliferation, chromosome instability and tumorigenesis.
Customer Reviews (3)
Write a reviewAURKA's exceptional stability allows for its reliable use in a range of applications, making it a top choice for researchers.
This protein's exceptional activity allows for its reliable use in a range of applications, making it a top choice for researchers.
Due to the extensive storage conditions of proteins, the experimental process is more stable and reliable, which provides a strong guarantee for scientific research.
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