AURKC
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Official Full Name
aurora kinase C
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Overview
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. -
Synonyms
AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC; AIK3; STK13; AIE 2; AIE2; AIK 3; ARK 3; ARK-3; Aur C; AURKC_HUMAN; aurora 3; Aurora C; aurora related kinase 3; Aurora-related kinase 3; Aurora/Ipl1 related kinase 3; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; Serine threonine protein kinase 13; serine/threonine kinase 13 (aurora/IPL1 like); serine/threonine protein kinase aurora C; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like); SPGF5; aurora-C;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- N/A
- No tag
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AURORA C-3779H | Recombinant Human AURORA C protein, GST-tagged | Insect Cell | GST | full-length |
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| Human | AURKC-990H | Recombinant Human Aurora Kinase C, GST-tagged | Sf9 Insect Cell | GST |
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| Human | AURKC-27499TH | Recombinant Human AURKC | N/A |
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| Human | AURKC-248H | Recombinant Human Aurora Kinase C, GST-tagged, Active | Sf9 Insect Cell | GST |
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| Human | AURKC-1039H | Recombinant Human AURKC protein, GST-tagged | Wheat Germ | GST |
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| Human | AURKC-8559HCL | Recombinant Human AURKC 293 Cell Lysate | HEK293 | N/A |
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| Human | AURKC-1114H | Recombinant Human AURKC Protein (S2-S309), Tag Free | Insect Cell | No tag | S2-S309 |
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| Human | AURKC-1853HF | Active Recombinant Full Length Human AURKC Protein, GST-tagged | Insect (sf21) | GST | 1-275(end) |
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| Human | AURKC-530H | Recombinant Human AURKC Protein, His-tagged | E.coli | His | Leu20~Gln277 |
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| Human | AURKC-1115H | Recombinant Human AURKC Protein (S2-S309), GST tagged | Insect Cell | GST | S2-S309 |
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| Human | AURKC-1060HF | Recombinant Full Length Human AURKC Protein, GST-tagged | In Vitro Cell Free System | GST | 309 amino acids |
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| Mouse | Aurkc-3782M | Recombinant Mouse Aurkc, His-tagged | E.Coli or Yeast | His | 282 |
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| Mouse | Aurkc-531M | Recombinant Mouse Aurkc Protein, His-tagged | E.coli | His | Thr5~Ala237 |
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| Rat | Aurkc-532R | Recombinant Rat Aurkc Protein, His-tagged | E.coli | His | Gly92~Pro339 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AURKC Related Articles
AURKC involved in several pathways and played different roles in them. We selected most pathways AURKC participated on our site, such as Aurora B signaling, Aurora C signaling, Signaling by Aurora kinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aurora B signaling | KIF20A;TACC1;RACGAP1;NCAPD2;SMC4;NSUN2;NPM1;SGOL1;CBX5 |
| Aurora C signaling | AURKC;AURKB;INCENP |
| Signaling by Aurora kinases |
AURKC has several biochemical functions, for example, ATP binding, histone serine kinase activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKC itself. We selected most functions AURKC had, and list some proteins which have the same functions with AURKC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP7A;AACS;PIF1;MAT2AA;PRPS1;TNIKB;CHD9;TOR1;LANCL2 |
| histone serine kinase activity | PRKAA1;AURKA;AURKB;PRKAA2;ATM;AURKC |
| protein kinase activity | RAF1B;CAMKVB;MAPK12A;NEK5;PRKG2;cka1;CAMK2B1;FASTKD1;MAP4K5 |
| protein serine/threonine/tyrosine kinase activity | TNK2;DYRK1B;TESK1;ACVR2B;DSTYK;AURKC;CLK1;MAP2K2;CLK4 |
AURKC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKC here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKC.
LRRK2; SRPK1; HSP90AB1; BIRC5
- Q&As
- Reviews
Q&As (6)
Ask a questionAURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.
The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.
The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.
AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.
Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.
Customer Reviews (3)
Write a reviewIt is very stable and can be stored and used for a long time.
This price is very reasonable and good value for money.
The activity is very strong and can meet my research needs.
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