b4galt7
Share
  • Official Full Name
  • xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
  • Background
  • Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
  • Synonyms
  • B4galt7; xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I); EDSP1; XGPT1; XGALT1; B4GALT7; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
Cat.#:B4GALT7-035HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B4GALT7 protein, GST-tagged
+Inquiry
Cat.#:B4GALT7-499RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey B4GALT7 Protein, His-tagged
+Inquiry
Cat.#:B4GALT7-3402CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken B4GALT7
+Inquiry
Cat.#:B4GALT7-870ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish B4GALT7
+Inquiry
Cat.#:B4GALT7-8536HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human B4GALT7 293 Cell Lysate
+Inquiry

Involved Pathway

B4GALT7 involved in several pathways and played different roles in them. We selected most pathways B4GALT7 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
A tetrasaccharide linker sequence is required for GAG synthesis
GPC1B; DCN; AGRN; BGNA; BGNB; VCANB; BCAN; BGN; Gpc2; VCAN
Chondroitin sulfate/dermatan sulfate metabolism
UST; GPC5; BGN; DSEL; GPC6; CSPG4; BCAN; CHST14; GPC5A; BGNA
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
B3GALT6; CHST3B; UST; CSGALNACT1; CHSY1; CHST3; CHPF2; XYLT2; CHST3A; CSGALNACT2
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
HS2ST1A; EXTL1; HS6ST2; NDST3; EXTL3; B3GAT3; HS3ST5; HS6ST1A; HS3ST1; HS3ST2
Glycosaminoglycan metabolism
CHST14; CHST9; Gpc2; BGNB; SLC26A1; KIAA1199; HS3ST6; GPC5A; HS3ST4; SLC26A2
Heparan sulfate/heparin (HS-GAG) metabolism
SLC35D2; B3GAT2; HS3ST6; GPC5A; GPC1A; GLB1L; CSPG5B; Gpc2; GPC1B; HS3ST4
Metabolic pathways
GULO; ALDH1A2; ADSS; AHCYL2; POLR1E; CYP2P6; EBP; TPH2; GALNT13; BAAT
Metabolism
IP6K3; AZIN1A; CPT2; ADAL; Sult2a2; AFMID; MED7; CA13; LYRM4; UGT1B2

Protein Function

B4GALT7 has several biochemical functions, for example, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, galactosyltransferase activity, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT7 itself. We selected most functions B4GALT7 had, and list some proteins which have the same functions with B4GALT7. You can find most of the proteins on our site.
Function
Related Protein
Function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
Related Protein B4GALT7; B4GALT1; B4GALT3; B4GALT2; WDFY3
Function galactosyltransferase activity
Related Protein B4GALT1; B3GNT5B; B4GALT7; DPY19L1; PIGB; POC1BL; B3GNT3; B3GNT4; B3GALT6; B4GALT5
Function manganese ion binding
Related Protein TDP2; FEN1; PPM1NB; MRE11A; PPM1B; NPEPL1; GALNT3; GALNT2; PPM1A; SOD2
Function protein binding
Related Protein KLK15; PSMB4; RANBP3; GPN1; GFI1B; SIX3; POLB; RBKS; RPRD1A; HIST1H2BI
Function xylosylprotein 4-beta-galactosyltransferase activity
Related Protein B4GALT7

Interacting Protein

B4GALT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT7.
RABGGTB; KRTAP10-7; Cep152; MYC; GBA; PCNA; EZR; ID1; YWHAZ; CDC16; Iffo2; THOC1; PEO1

B4GALT7 Related Articles

Cartault, F; Munier, P; et al. Expanding the clinical spectrum of B4GALT7 deficiency: homozygous p.R270C mutation with founder effect causes Larsen of Reunion Island syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:49-53(2015).
von Oettingen, JE; Tan, WH; et al. Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:1580-1586(2014).