bag2
Share
  • Official Full Name
  • BCL2-associated athanogene 2
  • Background
  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
  • Synonyms
  • BAG2; BCL2-associated athanogene 2; BAG family molecular chaperone regulator 2; bcl-2-associated athanogene 2; BAG-family molecular chaperone regulator-2; dJ417I1.2 (BAG-family molecular chaperone regulator 2); BAG-2; dJ417I1.2; KIAA0576; MGC149462
Cat.#:BAG2-052HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAG2 protein, GST-tagged
+Inquiry
Cat.#:BAG2-27436THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAG2, His-tagged
+Inquiry
Cat.#:BAG2-3406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAG2, His-tagged
+Inquiry
Cat.#:BAG2-2271MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAG2 Protein
+Inquiry
Cat.#:BAG2-506RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAG2 Protein, His-tagged
+Inquiry
Cat.#:BAG2-11233ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BAG2
+Inquiry
Cat.#:BAG2-8527HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAG2 293 Cell Lysate
+Inquiry

Involved Pathway

BAG2 involved in several pathways and played different roles in them. We selected most pathways BAG2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
DNAJC5B; NPLOC4; PDIA4; CAPN1A; RRBP1A; UBE2J1; MAN1A; UBE2G1A; UBE2G1B; TRAM1

Protein Function

BAG2 has several biochemical functions, for example, chaperone binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG2 itself. We selected most functions BAG2 had, and list some proteins which have the same functions with BAG2. You can find most of the proteins on our site.
Function
Related Protein
Function chaperone binding
Related Protein VWF; DLST; SDF2L1; BAX; ATP1A1; TSC1; PRNP; HSCB; AHSA2; H2-KE2
Function identical protein binding
Related Protein TRADD; HOOK2; ASMT; AMOTL2; MICALL1; STAC3; P2RX2; PFKL; CLDN10; CTSC
Function protein binding
Related Protein CSRNP2; DPH2; MYOG; DCUN1D1; RUVBL2; CENPW; FBXO32; ZNF365; LAX1; BNIP2

Interacting Protein

BAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG2.
MLF2; DNAJC7; HSPA8; SGTA; EBNA-LP; q96be0_human; STUB1

BAG2 Related Articles

De-Doncker, L; Picquet, F; et al. Expression of myosin heavy chain isoforms along intrafusal fibers of rat soleus muscle spindles after 14 days of hindlimb unloading. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 50:1543-1553(2002).
SCIOTE, JJ; et al. FIBER-TYPE DISTRIBUTION IN THE MUSCLE-SPINDLES OF CAT JAW-ELEVATOR MUSCLES. ARCHIVES OF ORAL BIOLOGY 38:685-688(1993).