baiap2
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  • Official Full Name
  • BAI1-associated protein 2
  • Background
  • The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein.;This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an;insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also;associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers;and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect;neuronal growth-cone guidance. This protein has also been identified as interacting with the;dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.;Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • BAIAP2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; BAP2; IRS-58; IRSp53/58; fas ligand-associated factor 3; insulin receptor substrate p53/p58; insulin receptor substrate protein of 53 kDa; FLAF3; IRSP53
Cat.#:BAIAP2-062HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAIAP2 protein, GST-tagged
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Cat.#:BAIAP2-187HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BAIAP2 protein, DDK-tagged
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Cat.#:BAIAP2-27437THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAIAP2, His-tagged
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Cat.#:BAIAP2-935RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BAIAP2 Protein
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Cat.#:BAIAP2-1373HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAI1-Associated Protein 2, His-tagged
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Cat.#:BAIAP2-8521HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAIAP2 293 Cell Lysate
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Cat.#:BAIAP2-8522HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAIAP2 293 Cell Lysate
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Involved Pathway

BAIAP2 involved in several pathways and played different roles in them. We selected most pathways BAIAP2 participated on our site, such as Adherens junction, CDC42 signaling events, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAIAP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junction
VCL; IGF1RA; ACTN4; SSX2IP; TJP1; TCF7L1A; WASLA; PTPRFB; CDC42L2; SMAD2
CDC42 signaling events
ACTR2; CFL1; ARPC5; ACTR3; IQGAP3; ARPC1B; EPS8; CDC42BPA; PAK4; ARPC3
ErbB1 downstream signaling
EPS8; ACTR2; WASF2; MAP3K2; ABI1; BAIAP2; ACTR3; EGR1; CHN2; ARF4
Fcgamma receptor (FCGR) dependent phagocytosis
MYO9B; WIPF3; ABI2; ACTR2; PLD4; ACTR3; PPAPDC1A; ABI1B; NCKIPSD; WASF2
Immune System
ASB3; KIF2C; ISG20; WASF3; OSCAR; BTR29; Txn1; CFHL4; B2ML; BTR12
Innate Immune System
NLRP4; CRP; POLR3H; PANX1A; PLD4; ABI1B; ABI1A; DEFA6; CLEC4A; DEFB116
RAC1 signaling pathway
NCKAP1; NOXO1; NOXA1; IQGAP3; ABI2; RACGAP1; BAIAP2; ABI1
RHO GTPase Effectors
RCC2; KIF14; ABI1A; RHPN2; RHOC; MKL1B; DIAPH1; NDEL1B; PMF1; RHOAE

Protein Function

BAIAP2 has several biochemical functions, for example, PDZ domain binding, cytoskeletal adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAIAP2 itself. We selected most functions BAIAP2 had, and list some proteins which have the same functions with BAIAP2. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein KIF14; TBC1D10A; ARHGEF16; LNX1; CADM1; LLGL2; PTENA; MAP2K2; Fzd4; KIDINS220B
Function cytoskeletal adaptor activity
Related Protein NCK2; GAS2L1; BIN3; BAIAP2L2; BAIAP2A; BAIAP2L1; COX4I2; BAIAP2L1A; ANK1; GAS2L2
Function identical protein binding
Related Protein HCFC1; INHBA; VCP; SMAD1; WRNIP1; GOT2; TP73; ALK; MICU1; RALYL
Function proline-rich region binding
Related Protein CCND1; GAREM; FAM59A; CYLD; GHR; PRPF40A; ITSN1; BAIAP2; APBB1; WBP4
Function protein C-terminus binding
Related Protein TFCP2; TERF2; SIAH1A; LCK; NIPBL; SHANK3; PIAS4; HIC2; TBL1X; ERCC4
Function protein binding
Related Protein ZCCHC17; FBXO45; LOXL3; LINGO1; NTF3; SPON2; HIST4H4; LMAN1; BIN2; PDGFRB

Interacting Protein

BAIAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAIAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAIAP2.
EPS8; RAC1; Eps8