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BBS1

  • Official Full Name

    Bardet-Biedl syndrome 1 (human)

  • Overview

    Bardet-Biedl syndrome 1 protein is a protein that in humans is encoded by the BBS1 gene.
  • Synonyms

    BBS1; Bardet-Biedl syndrome 1 (human); Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 1 protein; BBS1_HUMAN; BBS2-like protein 2; Bardet-Biedl syndrome 1 homolog; AI451249; D19Ertd609e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Zebrafish
  • E. coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
  • His,SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BBS1-104H Recombinant Human BBS1 Protein, GST-tagged Wheat Germ GST
Human BBS1-105H Recombinant Human BBS1 Protein, GST-tagged Wheat Germ GST
Human BBS1-8504HCL Recombinant Human BBS1 293 Cell Lysate HEK293 N/A
Human BBS1-01HFL Recombinant Full Length Human BBS1 Protein, N-His-SUMO-tagged E. coli N-His,SUMO Full Length
Human BBS1-1583HF Recombinant Full Length Human BBS1 Protein, GST-tagged In Vitro Cell Free System GST 463 amino acids
Zebrafish BBS1-5671Z Recombinant Zebrafish BBS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BBS1 Related Articles

BBS1 involved in several pathways and played different roles in them. We selected most pathways BBS1 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of the primary ciliumCEP97;NDE1;NPHP3;DYNLL2;CETN2;LZTFL1;CCT8;HSPB11;CENPJ
BBSome-mediated cargo-targeting to ciliumSSTR3;CCT2;CCT5;PROL1;BBS12;TTC8;BBS10;CCT4;CCT3
Cargo trafficking to the periciliary membraneCCT8;RHOL;CCT5;BBS1;ARF4A;PKD2;ARL13B;PROL1;EXOC3
Organelle biogenesis and maintenanceDYNLL2A;CYS1;TTBK2;BBS4;FLR;EXOC1;PKD2;MRPL49;MRPL37

BBS1 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, patched binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS1 itself. We selected most functions BBS1 had, and list some proteins which have the same functions with BBS1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II repressing transcription factor bindingGATA6;TTC8;BBS1;HDAC2;DMAP1;RBBP8;MTA1;SP1;BBS4
patched bindingSMO;PTCH1;IHH;SETD6;CCNB1;CAV1;Shh;DHH;BBS1
protein bindingSDCCAG8;MRPL20;TBC1D2;FIS1;APEH;CYBB;SYMPK;ZNF295;HOXA9
smoothened bindingPTCH2;BBS1;PTCH1

BBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS1.

BBS9; BBS7; BBS5; BBS4

Rabinovich-Nikitin, I; Solomon, B; et al. Inhibition of Amyloid Precursor Protein Processing Leads to Downregulation of Apoptotic Genes in Alzheimer's Disease Animal Models. NEURODEGENERATIVE DISEASES 13:107-109(2014).
Seo, S; Mullins, RF; et al. Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:6118-6132(2013).
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