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BBS2

Official Full Name

Bardet-Biedl syndrome 2
Overview

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.
Synonyms

BBS2; Bardet-Biedl syndrome 2; BBS; Bardet-Biedl syndrome 2 protein; Bardet Biedl syndrome 2; Bardet Biedl syndrome 2 protein; MGC20703;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BBS2-107H	Recombinant Human BBS2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BBS2-8503HCL	Recombinant Human BBS2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	BBS2-1585HF	Recombinant Full Length Human BBS2 Protein, GST-tagged	In Vitro Cell Free System	GST	721 amino acids	Inquiry
Mouse	BBS2-2311M	Recombinant Mouse BBS2 Protein	Mammalian Cell	His		Inquiry
Mouse	BBS2-974M	Recombinant Mouse BBS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	BBS2-974M-B	Recombinant Mouse BBS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	BBS2-948R	Recombinant Rat BBS2 Protein	Mammalian Cell	His		Inquiry
Rat	BBS2-606R	Recombinant Rat BBS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	BBS2-606R-B	Recombinant Rat BBS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	BBS2-9411Z	Recombinant Zebrafish BBS2	Mammalian Cell	His		Inquiry
Chicken	BBS2-2006C	Recombinant Chicken BBS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

BBS2 involved in several pathways and played different roles in them. We selected most pathways BBS2 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	TRIP11;ARF4A;SDCCAG8;TTC30B;DYNLL2;TTC26;EXOC6;PKD2;BBS4
BBSome-mediated cargo-targeting to cilium	LZTFL1;BBS1;TCP1;BBS7;BBS5;RAB3IP;BBS2;CCT5;BBS4
Cargo trafficking to the periciliary membrane	EXOC5;PROL1;RAB3IP;BBS10;CYS1;CNGA5;CCT4;RHOL;NPHP3
Organelle biogenesis and maintenance	MRPL10;MRPL44;DYNLRB2;ICT1;IFT81;KIFAP3A;MARK4;MRPS28;WDR35

BBS2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS2 itself. We selected most functions BBS2 had, and list some proteins which have the same functions with BBS2. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II repressing transcription factor binding	TBX5A;GSC;TCERG1;GTF2A2;GATA6;SP1;MIXL1;SIN3A;RBBP8
protein binding	ABL2;GEMIN6;YWHAQ;BRD7;MATK;PRKAA1;MLH3;CIRBP;BASP1

BBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS2.

BBS9; BBS7