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BBS5

  • Official Full Name

    Bardet-Biedl syndrome 5

  • Overview

    This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is required for the formation of cilia. Alternate transcriptional splice variants have been observed but have not been fully characterized.
  • Synonyms

    BBS5; Bardet-Biedl syndrome 5; Bardet-Biedl syndrome 5 protein; DKFZp762I194; Bardet Biedl syndrome 5 protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BBS5-109H Recombinant Human BBS5 Protein, GST-tagged Wheat Germ GST
Human BBS5-8501HCL Recombinant Human BBS5 293 Cell Lysate HEK293 N/A
Human BBS5-1589HF Recombinant Full Length Human BBS5 Protein, GST-tagged In Vitro Cell Free System GST 341 amino acids
Mouse BBS5-2313M Recombinant Mouse BBS5 Protein Mammalian Cell His
Mouse BBS5-975M Recombinant Mouse BBS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BBS5-975M-B Recombinant Mouse BBS5 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BBS5-336C Recombinant Cynomolgus BBS5 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BBS5-84C Recombinant Cynomolgus Monkey BBS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey BBS5-84C-B Recombinant Cynomolgus Monkey BBS5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BBS5-516R Recombinant Rhesus monkey BBS5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BBS5-344R-B Recombinant Rhesus Macaque BBS5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BBS5-344R Recombinant Rhesus Macaque BBS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BBS5-10630Z Recombinant Zebrafish BBS5 Mammalian Cell His
Chicken BBS5-4532C Recombinant Chicken BBS5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BBS5 Related Articles

BBS5 involved in several pathways and played different roles in them. We selected most pathways BBS5 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of the primary ciliumCCT5;EXOC5;MAPRE1;CLASP1;BBS5;ARL3;RP2;TMEM216;IFT122
BBSome-mediated cargo-targeting to ciliumLZTFL1;CCT5;BBS5;PROL1;BBS2;TTC8;CCT3;SSTR3;BBS7
Cargo trafficking to the periciliary membraneLZTFL1;EXOC5;CNGA2;ARL13B;BBS9;SETD6;ARF4A;BBS7;RP2
Organelle biogenesis and maintenancePOLRMT;MRPS23;MRPS27;IFT80;MTRF1L;TRAF3IP1;MRPL53;BBS4;DYNLL2B

BBS5 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, phosphatidylinositol-3-phosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS5 itself. We selected most functions BBS5 had, and list some proteins which have the same functions with BBS5. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II repressing transcription factor bindingTCERG1;TBP;TCF7L2;BBS2;MTA1;BBS5;TBX5A;HDAC2;SP1
phosphatidylinositol-3-phosphate bindingRS1;VPS36;LANCL2;KIF16B;WDR45L;PHLDA3;D6WSU116E;SNX24;SNX19
protein bindingHSD17B10;TAP1;SSBP3;SLC26A3;CPSF4;GAPDHS;AHNAK2;CDKN1A;HIPK2

BBS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS5.

BBS1; BBS4; 147700; CRADD; BBS9; KLC3

Kagaya, A; Shimada, H; et al. Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. PROTEOME SCIENCE 9:-(2011).
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