bcar1
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  • Official Full Name
  • breast cancer anti-estrogen resistance 1
  • Background
  • BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
  • Synonyms
  • BCAR1; breast cancer anti-estrogen resistance 1; CAS; CAS1; CASS1; CRKAS; P130Cas; breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Cas scaffolding protein family member 1;
Cat.#:BCAR1-563HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCAR1 Protein, His-tagged
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Cat.#:BCAR1-120HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCAR1 Protein, GST-tagged
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Cat.#:BCAR1-121HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCAR1 Protein, GST-tagged
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Cat.#:BCAR1-441HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human breast cancer anti-estrogen resistance 1, His-tagged
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Cat.#:BCAR1-5042HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCAR1, His-tagged
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Cat.#:BCAR1-950RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCAR1 Protein
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Cat.#:BCAR1-7186ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BCAR1
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Cat.#:BCAR1-8498HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCAR1 293 Cell Lysate
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Involved Pathway

BCAR1 involved in several pathways and played different roles in them. We selected most pathways BCAR1 participated on our site, such as Rap signaling pathway, Chemokine signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
IGF1R; NGF; PIK3CD; PIK3R1; VAV2; INSR; PIK3CB; RAC1; FGFR3; ITGB2L
Chemokine signaling pathway
RAP1A; CCR1; KRAS; BCAR1; CCR8; CX3CR1; MAPK1; GM13304; ROCK2; GNG12
Focal adhesion
LAMA5; PTENB; ITGA6; VTNA; PDGFC; COL27A1B; CCND2; ACTN2; TLN1; ROCK2A
Leukocyte transendothelial migration
CLDN22; ROCK1; ITGAM; CLDN2; ACTN1; CLDN15; ITGA4; CD99; CLDN17; MAPK13
Regulation of actin cytoskeleton
MLCK2; ITGAX; ITGA8; PPP1R12C; F2R; PAK6; BAIAP2A; MYL2B; GNG12A; PIP5K1BB
Bacterial invasion of epithelial cells
CAV3; CTNNA2; PIK3R5; ELMO3; CLTB; SEPT6; VCL; CBLB; PIK3CB; CTNNA3

Protein Function

BCAR1 has several biochemical functions, for example, SH3 domain binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAR1 itself. We selected most functions BCAR1 had, and list some proteins which have the same functions with BCAR1. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein KHDRBS1; ITM2B; SKAP1; LANCL1; KHDRBS3; CD3E; EPS15; ADAM17; GJA1; CD2AP
Function protein binding
Related Protein THEM5; ITGA3; SOAT1; HHEX; LANCL1; OBSCN; COMTD1; AIFM1; MT1A; EIF4EBP1
Function protein kinase binding
Related Protein RHEB; GRB7; MAG; PRKRIP1; PTPN2; KIF14; MSH2; IL31RA; TSKS; PRKACA
Function signal transducer activity
Related Protein VMN1R40; STAT1A; GNAL; PPP5C; PLCD3A; TRADD; CD24; V1RA8; OLFR18; MC5RA

Interacting Protein

BCAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAR1.
PTPN1; CRK; SRC; FYN; PTPN12

BCAR1 Related Articles

Jardel, P; Debiais, C; et al. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. HISTOPATHOLOGY 63:57-63(2013).
van Agthoven, T; Godinho, MFE; et al. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 131:1998-2007(2012).