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BCAR3

  • Official Full Name

    breast cancer anti-estrogen resistance 3

  • Overview

    Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.
  • Synonyms

    BCAR3; breast cancer anti-estrogen resistance 3; breast cancer anti-estrogen resistance protein 3; NSP2; SH2D3B; BCAR 3; Novel SH2 containing protein 2; SH2 domain containing protein 3B; Breast cancer anti estrogen resistance 3; Breast cancer anti estrogen resistance protein 3; Breast cancer antiestrogen resistance 3; dJ1033H22.2; dJ1033H22.2 breast cancer anti estrogen resistance 3; dJ1033H22.2 breast cancer antiestrogen resistance 3; KIAA0554; NSP 2; SH2 containing protein Nsp2; OTTHUMP00000011959; OTTHUMP00000011960; OTTHUMP00000011961; OTTHUMP00000011962; novel SH2-containing protein 2; SH2 domain-containing protein 3B; dJ1033H22.2 (breast cancer anti-estrogen resistance 3);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCAR3-122H Recombinant Human BCAR3 Protein, GST-tagged Wheat Germ GST
Human BCAR3-8497HCL Recombinant Human BCAR3 293 Cell Lysate HEK293 N/A
Human BCAR3-431H Recombinant Human BCAR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCAR3-2594H Recombinant Human BCAR3 protein, His-tagged E.coli His 1-117 aa
Human BCAR3-1759HFL Recombinant Full Length Human BCAR3 Protein, C-Flag-tagged Mammalian cells Flag
Human BCAR3-431H-B Recombinant Human BCAR3 Protein Pre-coupled Magnetic Beads HEK293
Human BCAR3-562H Recombinant Human BCAR3 Protein, His/GST-tagged E.coli His/GST Asp548~Pro818
Human BCAR3-5165H Recombinant Human BCAR3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BCAR3-0255H Recombinant Human BCAR3 Protein (Asp548-Pro818), N-His-tagged E.coli N-His Asp548-Pro818
Mouse BCAR3-2322M Recombinant Mouse BCAR3 Protein Mammalian Cell His
Mouse Bcar3-1841M Recombinant Mouse Bcar3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse BCAR3-980M Recombinant Mouse BCAR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BCAR3-980M-B Recombinant Mouse BCAR3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BCAR3-337C Recombinant Cynomolgus BCAR3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BCAR3-85C Recombinant Cynomolgus Monkey BCAR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey BCAR3-85C-B Recombinant Cynomolgus Monkey BCAR3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BCAR3-6347Z Recombinant Zebrafish BCAR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BCAR3 involved in several pathways and played different roles in them. We selected most pathways BCAR3 participated on our site, such as Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of CDC42 activityBCAR3;DOCK6;ARHGAP17;ARHGAP1;ITSN2;DNMBP;MCF2L;RALBP1;SPATA13

BCAR3 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAR3 itself. We selected most functions BCAR3 had, and list some proteins which have the same functions with BCAR3. You can find most of the proteins on our site.

Function Related Protein
guanyl-nucleotide exchange factor activityDOCK8;TBXAS1;SBF1;ITSN2A;ARHGEF18;RINL;DOCK5;VAV3;ARHGEF17
protein bindingOLR1;ARPM1;TAOK3;DNAI1;PRICKLE1A;NLGN3;GTF2A2;ZC3H12A;NOC2L

BCAR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAR3.

IRS1; NEDD9; ERBB2; MET; KIT; ERBB3; GAB1; 4504555; PFAS; RTN3; GOT2; TPM3

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